Effect of the leukotriene B4 receptor antagonist, SC-41930, on experimental allergic encephalomyelitis (EAE) in the guinea pig

1991 ◽  
Vol 34 (1-2) ◽  
pp. 172-174 ◽  
Author(s):  
D. J. Fretland ◽  
D. L. Widomski ◽  
R. L. Shone ◽  
S. Levin ◽  
T. S. Gaginella
Keyword(s):  
Guinea Pig ◽  
Receptor Antagonist ◽  
Experimental Allergic Encephalomyelitis ◽  
Leukotriene B4 ◽  
Allergic Encephalomyelitis ◽  
Leukotriene B4 Receptor ◽  
Experimental Allergic

scholarly journals Inhibition of leukotriene B4-receptor interaction suppresses eosinophil infiltration and disease pathology in a murine model of experimental allergic encephalomyelitis.

1996 ◽  
Vol 183 (4) ◽  
pp. 1893-1898 ◽  
Author(s):  
R P Gladue ◽  
L A Carroll ◽  
A J Milici ◽  
D N Scampoli ◽  
H A Stukenbrok ◽  
...  
Keyword(s):  
Experimental Allergic Encephalomyelitis ◽  
Murine Model ◽  
Light And Electron Microscopy ◽  
Leukotriene B4 ◽  
Eosinophil Infiltration ◽  
Receptor Interaction ◽  
Allergic Encephalomyelitis ◽  
Leukotriene B4 Receptor ◽  
Experimental Allergic ◽  
Ltb4 Receptor

Leukotriene B4 (LTB4) is a chemotactic and cell-activating factor present at inflammatory sites in a variety of autoimmune diseases including multiple sclerosis (MS). In this study, we used a murine model of MS, experimental allergic encephalomyelitis (EAE), to assess the potential role of LTB4 on cell infiltration and paralysis. Injection of encephalogenic T cells into naive animals induced paralysis and weight loss that was completely inhibited by treatment with the selective LTB4 receptor antagonist CP-105,696 (ED50= 8.6 mg/kg orally). Although migration of lymphocytes into the central nervous system was unaffected, the efficacious effects of CP-105,696 correlated with up to a 97% decrease in eosinophil infiltration into the lower spinal cord as determined by light and electron microscopy and quantitated by levels of the specific enzyme marker eosinophil peroxidase. These results demonstrate that eosinophil recruitment in EAE is dependent on LTB4 receptor ligation and further reveal a previously unrecognized role for eosinophils in the pathogenesis of this disease.

scholarly journals Transfer of experimental allergic encephalomyelitis in Lewis rats using supernates of incubated sensitized lymph node cells.

1977 ◽  
Vol 145 (5) ◽  
pp. 1405-1410 ◽  
Author(s):  
C C Whitacre ◽  
P Y Paterson
Keyword(s):  
Spinal Cord ◽  
Lymph Node ◽  
Guinea Pig ◽  
Experimental Allergic Encephalomyelitis ◽  
Nervous Tissue ◽  
Allergic Encephalomyelitis ◽  
Lewis Rats ◽  
Transfer Activity ◽  
Lymph Node Cells ◽  
Experimental Allergic

Supernates derived from incubated lymph node cells of Lewis rats sensitized to guinea pig spinal cord-Freund's adjuvant transfer experimental allergic encephalomyelitis (EAE) to syngeneic recipients. EAE supernatant transfer activity (EAE-STA) is not demonstrable in supernates derived from LNC of control donors not sensitized to nervous tissue. After addition of brain antigen to active supernates, EAE-STA is not longer demonstrable.

T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis

1994 ◽  
Vol 24 (4) ◽  
pp. 940-946 ◽  
Author(s):  
Alessandra Franco ◽  
Scott Southwood ◽  
Thomas Arrhenius ◽  
Vijay K. Kuchroo ◽  
Howard M. Grey ◽  
...  
Keyword(s):  
T Cell ◽  
Receptor Antagonist ◽  
T Cell Receptor ◽  
Experimental Allergic Encephalomyelitis ◽  
Cell Receptor ◽  
Allergic Encephalomyelitis ◽  
Antagonist Peptides ◽  
Highly Effective ◽  
Experimental Allergic
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