Pathophysiology of alcoholic brain damage: synergistic effects of ethanol, thiamine deficiency and alcoholic liver disease

1995 ◽  
Vol 10 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Roger F. Butterworth
Keyword(s):  
Liver Disease ◽  
Brain Damage ◽  
Alcoholic Liver Disease ◽  
Thiamine Deficiency ◽  
Synergistic Effects ◽  
Alcoholic Brain Damage

scholarly journals Study of viral markers, clinical and biochemical profile of viral hepatitis in patients of alcoholic liver disease

2020 ◽  
Vol 7 (2) ◽  
pp. 196
Author(s):  
Narendra M. Uma ◽  
Mahendra C. Parmar ◽  
Parth Shanishwara ◽  
Sonal M. Dindod
Keyword(s):  
Liver Disease ◽  
Alcohol Consumption ◽  
Viral Hepatitis ◽  
Alcoholic Liver Disease ◽  
Hepatitis Virus ◽  
Synergistic Effects ◽  
Biochemical Profile ◽  
Hepatitis Viruses ◽  
Cross Sectional ◽  
Targeted Interventions

Background: There is a significant worldwide burden of Alcoholic Liver Disease (ALD). Both alcohol abuse and infection with hepatitis viruses can lead to liver disease. Alcohol and hepatitis viruses have synergistic effects in the development of liver disease. Thus, early detection of virus hepatitis and targeted interventions can improve prognosis in ALD.Methods: This cross-sectional study was conducted among 180 patients coming to Baroda medical college and SSG hospital, Vadodara having alcoholic liver disease were studied and evaluated for markes of viral hepatitis and its clinical and biochemical profile in alcoholic liver disease.Results: our study we had taken 180 patients of alcoholic liver disease out of which male were 92% and female were 8%. Prevalence of viral hepatitis was 27.7% in ALD patients. Out of which hepatitis E was 13% followed by hepatitis A 11%, hepatitis B 4.44% and least was Hepatitis C 0.5%. In clinical profile fever was significantly higher in patients of viral hepatitis with ALD than patients without viral hepatitis.  Bilirubin was not significant differ in both groups of patients but SGOT and SGPT had higher values in patients of viral hepatitis with ALD and thus ratio of SGOT/SGPT was also affected  due to higher value of SGOT and SGPT.Conclusions: Alcohol consumption and hepatitis virus infection have a synergic hepatotoxic effect, and the coexistence of these factors increases the risk of advanced liver disease. Patients starting treatment for chronic viral hepatitis infection should be specifically advised to stop or reduce alcohol consumption because of its potential impact on treatment efficacy and adherence and may benefit from additional support during antiviral therapy specially in chronic hepatitis.

Crystalloid Inclusions in Hepatocyte Mitochondria and Their Similarity to Cytoplasmic Crystalloids

1974 ◽  
Vol 32 ◽  
pp. 198-199
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Special Interest ◽  
Structural Variations ◽  
Mitochondrial Alterations ◽  
The Matrix ◽  
Crystalloid Inclusions ◽  
Liver Biopsies

Mitochondrial alterations were studied in 25 liver biopsies from patients with alcoholic liver disease. Of special interest were the morphologic resemblance of certain fine structural variations in mitochondria and crystalloid inclusions. Four types of alterations within mitochondria were found that seemed to relate to cytoplasmic crystalloids.Type 1 alteration consisted of localized groups of cristae, usually oriented in the long direction of the organelle (Fig. 1A). In this plane they appeared serrated at the periphery with blind endings in the matrix. Other sections revealed a system of equally-spaced diagonal lines lengthwise in the mitochondrion with cristae protruding from both ends (Fig. 1B). Profiles of this inclusion were not unlike tangential cuts of a crystalloid structure frequently seen in enlarged mitochondria described below.

Alcohol consumption patterns in heavy drinkers with and without alcoholic liver disease (ALD)

2001 ◽  
Vol 120 (5) ◽  
pp. A117-A117
Author(s):  
K DEAR ◽  
M BRADLEY ◽  
K MCCORMACK ◽  
R PECK ◽  
D GLEESON
Keyword(s):  
Liver Disease ◽  
Alcohol Consumption ◽  
Alcoholic Liver Disease ◽  
Consumption Patterns ◽  
Heavy Drinkers

Altered phosphoethanolamine levels in alcoholic liver disease assessed by in vivo proton-decoupled 31P MR spectroscopic imaging

2001 ◽  
Vol 120 (5) ◽  
pp. A116-A116
Author(s):  
H SCHLEMMER ◽  
T SAWATZKI ◽  
I DORNACHER ◽  
S SAMMET ◽  
M HELLENSCHMIDT ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Spectroscopic Imaging ◽  
Mr Spectroscopic Imaging

Increased liver stiffness in alcoholic liver disease: Dissecting fibrosis from steatohepatitis

2010 ◽  
Vol 48 (01) ◽  
Author(s):  
S Mueller ◽  
G Millonig ◽  
S Friedrich ◽  
F Stickel ◽  
T Longerich ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Liver Stiffness

Alpha 1 antitrypsin ameliorates experimental alcoholic liver disease and determines patient outcome

2019 ◽  
Author(s):  
C Grander ◽  
B Schäfer ◽  
F Grabherr ◽  
B Enrich ◽  
M Sangineto ◽  
...  
Keyword(s):  
Patient Outcome ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Alpha 1 Antitrypsin
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