Interleukin 1 mediated acceleration of type II collagen-induced arthritis: Effects of anti-inflammatory or anti-arthritic drugs

1991 ◽  
Vol 33 (3-4) ◽  
pp. 300-309 ◽  
Author(s):  
J. T. Hom ◽  
V. L. Gliszczynski ◽  
H. W. Cole ◽  
A. M. Bendele
Keyword(s):  
Interleukin 1 ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Anti Inflammatory

scholarly journals Crocin exerts anti-inflammatory and anti-arthritic effects on type II collagen-induced arthritis in rats

2018 ◽  
Vol 56 (1) ◽  
pp. 209-216 ◽  
Author(s):  
Wei Liu ◽  
Yufeng Sun ◽  
Zhenping Cheng ◽  
Yong Guo ◽  
Peiming Liu ◽  
...  
Keyword(s):  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Anti Inflammatory

Involvement of interleukin-1-like factor(s) in type II collagen-induced arthritis in mice

1990 ◽  
Vol 26 (2) ◽  
pp. 171-175 ◽  
Author(s):  
T. Kasama ◽  
K. Kobayashi ◽  
H. Kanemitsu ◽  
K. Nakatani ◽  
S. Kaga ◽  
...  
Keyword(s):  
Interleukin 1 ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Induced Arthritis

Interleukin-1 potentiates the development of collagen-induced arthritis in mice

1989 ◽  
Vol 76 (5) ◽  
pp. 535-538 ◽  
Author(s):  
L. M. Killar ◽  
C. J. Dunn
Keyword(s):  
Immune Response ◽  
Interleukin 1 ◽  
Subcutaneous Administration ◽  
Type Ii Collagen ◽  
Interleukin 1Β ◽  
Type Ii ◽  
Collagen Induced Arthritis

1. The subcutaneous administration of recombinant human interleukin-1β (rhIL-1β) was found to induce an increased incidence and earlier onset of collagen-induced arthritis in mice. 2. The rhIL-1β had different effects, depending on when it was administered after collagen-immunization. 3. The effect of rhIL-1β may be due, in part, to augmentation of the immune response to type II collagen. 4. Interleukin-1-accelerated, collagen-induced arthritis will provide a useful model for investigating the role of interleukin-1 in the regulation of arthritic diseases, and the development of anti-arthritic therapeutics.

scholarly journals The effect of an interleukin-1 receptor antagonist protein on type ii collagen–induced arthritis and antigen-induced arthritis in mice

1993 ◽  
Vol 36 (9) ◽  
pp. 1305-1314 ◽  
Author(s):  
Paul H. Wooley ◽  
Janey D. Whalen ◽  
Darryl L. Chapman ◽  
Ann E. Berger ◽  
Karen A. Richard ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Interleukin 1 Receptor Antagonist

Anti-inflammatory Effect of Bee Venom on Type II Collagen-Induced Arthritis

2004 ◽  
Vol 32 (03) ◽  
pp. 361-367 ◽  
Author(s):  
Jae-Dong Lee ◽  
Su-Young Kim ◽  
Tae-Woo Kim ◽  
Sang-Hoon Lee ◽  
Hyung-In Yang ◽  
...  
Keyword(s):  
Acupuncture Therapy ◽  
Acupuncture Point ◽  
Type Ii Collagen ◽  
Bee Venom ◽  
Control Group ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Collagen Injection ◽  
Tnf Α ◽  
Anti Inflammatory

Bee venom (BV) has been used to relieve pain and reduce inflammation in traditional Oriental medicine, especially in chronic inflammatory diseases such as rheumatoid arthritis (RA). We previously reported that the BV injection into a traditional acupuncture point (Zusanli) reduced arthritis-associated edema and nociceptive responses in Freund's adjuvant-induced arthritis in rats (Kwon et al., 2001). This study was designed to evaluate the anti-inflammatory and anti-cytokine effect of BV on a murine type-II collagen-induced arthritis (CIA) model. Male mice were immunized by spontaneous injection of 100 μg of an emulsion of bovine type-II collagen and complete Freund's adjuvant (CFA), with a booster injection after 2 weeks. In the experimental group, 0.1 ml BV was injected at acupuncture point (Zusanli) near both knees twice a week for a total of 5 times. In the control group, normal saline was injected at the same frequencies. These injections began 5 weeks after the first collagen injection. Starting the 3rd week after the first collagen injection, we examined limb swelling and severity of arthritis twice a week. At 8 weeks, mice were sacrificed and synovial tissue was examined with the light microscope and serum cytokines (IL-1β and TNF-α) were measured by ELISA. The incidence of arthritis, the mean arthritis index and the number of arthritic limbs were significantly lower in the treatment compared to the control group (63% versus 75%, 3.4% versus 8.5%, 23% versus 75%, respectively). Among the serum proinflammatory cytokines, the production of TNF-α in the BV group was suppressed compared to the control group (59+/-4.5 versus 99.5+/-6.5, p <0.05), but IL-1β was not suppressed. The examination of the histopathology of the joints of murine CIA showed decreased inflammation signs and less lymphocyte infiltration after BV acupuncture therapy. Acupuncture therapy with BV suppressed the development of arthritis and caused inhibition of the immune responses in type-II collagen-induced arthritis.

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