Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection

1991 ◽  
Vol 32 (1-2) ◽  
pp. 10-21 ◽  
Author(s):  
R. R. Bartlett ◽  
M. Dimitrijevic ◽  
T. Mattar ◽  
T. Zielinski ◽  
T. Germann ◽  
...  
Keyword(s):  
Autoimmune Disorders ◽  
Transplantation Rejection ◽  
Immunomodulating Compound

Oxidative stress may develop endometrial autoimmune disorders

2002 ◽  
Vol 48 (3) ◽  
pp. 136-137
Author(s):  
A. Iborra ◽  
J.R. Palacio ◽  
M. Mayorga ◽  
E. Garcia ◽  
Z. Ulcova-Gallova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Autoimmune Disorders

Therapeutic Plasma Exchange Application in Children Requires Individual Decision

2020 ◽  
Author(s):  
Gürkan Atay ◽  
Demet Demirkol
Keyword(s):  
Plasma Exchange ◽  
Vascular Access ◽  
Pediatric Patients ◽  
Demyelinating Disease ◽  
Pediatric Intensive Care ◽  
Therapeutic Plasma Exchange ◽  
Transplantation Rejection ◽  
Access Problems ◽  
Uremic Syndrome

AbstractTherapeutic plasma exchange (TPE) is a treatment administered with the aim of removing a pathogenic material or compound causing morbidity in a variety of neurologic, hematologic, renal, and autoimmune diseases. In this study, we aimed to assess the indications, efficacy, reliability, complications, and treatment response of pediatric patients for TPE. This retrospective study analyzed data from 39 patients aged from 0 to 18 years who underwent a total of 172 TPE sessions from January 2015 to April 2018 in a tertiary pediatric intensive care unit. Indications for TPE were, in order of frequency, macrophage activation syndrome (28.2%, n = 11), renal transplantation rejection (15.4%, n = 6), liver failure (15.4%, n = 6), Guillain–Barre's syndrome (15%, n = 6), hemolytic uremic syndrome (7.7%, n = 3), acute demyelinating disease (7.7%, n = 3), septic shock (5.1%, n = 2), and intoxication (5.1%, n = 2). No patient had any adverse event related to the TPE during the procedure. The TPE session was ended prematurely in one patient due to insufficient vascular access and lack of blood flow (2.6%). In the long term, thrombosis due to the indwelling central catheter occurred (5.1%, n = 2). TPE appears to be an effective first-stage or supplementary treatment in a variety of diseases, may be safely used in pediatric patients, and there are significant findings that its area of use will increase. In experienced hands and when assessed carefully, it appears that the rate of adverse reactions and vascular access problems may be low enough to be negligible.

Autoimmune thyroiditis and repeated pregnancy loss: a role for associated autoimmune disorders?

2018 ◽  
Author(s):  
Camilla Virili ◽  
Miriam Cellini ◽  
Maria Giulia Santaguida ◽  
Nunzia Brusca ◽  
Ilaria Stramazzo ◽  
...  
Keyword(s):  
Autoimmune Thyroiditis ◽  
Pregnancy Loss ◽  
Autoimmune Disorders ◽  
Repeated Pregnancy Loss
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