The anti-inflammatory activity of a low molecular weight component derived from the milk of hyperimmunized cows

1991 ◽  
Vol 32 (3-4) ◽  
pp. 160-166 ◽  
Author(s):  
D. J. Ormrod ◽  
T. E. Miller
Keyword(s):  
Molecular Weight ◽  
Inflammatory Activity ◽  
Low Molecular Weight ◽  
Anti Inflammatory

Anti-Inflammatory Activity in the Low Molecular Weight Fraction of Commercial Human Serum Albumin (LMWF5A)

2015 ◽  
Vol 37 (1) ◽  
pp. 55-67 ◽  
Author(s):  
Gregory W. Thomas ◽  
Leonard T. Rael ◽  
Charles W. Mains ◽  
Denetta Slone ◽  
Matthew M. Carrick ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Weight Fraction ◽  
Inflammatory Activity ◽  
Low Molecular Weight ◽  
Anti Inflammatory

scholarly journals A selective novel low-molecular-weight inhibitor of Iκ B kinase-β (IKK-β ) prevents pulmonary inflammation and shows broad anti-inflammatory activity

2005 ◽  
Vol 145 (2) ◽  
pp. 178-192 ◽  
Author(s):  
Karl Ziegelbauer ◽  
Florian Gantner ◽  
Nicholas W Lukacs ◽  
Aaron Berlin ◽  
Kinji Fuchikami ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Pulmonary Inflammation ◽  
Inflammatory Activity ◽  
Low Molecular Weight ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Anahita Shahraz ◽  
Jens Kopatz ◽  
Rene Mathy ◽  
Joachim Kappler ◽  
Dominic Winter ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Polysialic Acid ◽  
Inflammatory Activity ◽  
Low Molecular Weight ◽  
Human Macrophages ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory activity of soluble chito-oligosaccharides (CHOS) on VitD3-induced human THP-1 monocytes

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246381
Author(s):  
Paiboon Jitprasertwong ◽  
Munthipha Khamphio ◽  
Phornsiri Petsrichuang ◽  
Vincent G. H. Eijsink ◽  
Wanangkan Poolsri ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Vitamin D3 ◽  
Biological Effects ◽  
Water Soluble ◽  
Inflammatory Activity ◽  
Low Molecular Weight ◽  
Dependent Manner ◽  
Human Immune ◽  
Anti Inflammatory ◽  
Dose Dependent

Chito-oligosaccharides (CHOS) are oligomers of D-glucosamine and N-acetyl-glucosamine. Anti-inflammatory activities of a wide variety of CHOS mixtures have previously been reported, mainly based on studies with mouse models and murine macrophages. Since the mouse and human immune systems are quite different, gaining insight into the activity of CHOS on human cell lines, using well-characterized CHOS mixtures, is of considerable interest. Bacillus subtilis chitosanase (BsCsn46A) can efficiently convert chitosan to mixtures of water soluble low molecular weight CHOS. Here, the anti-inflammatory activity of a properly characterized CHOS mixture was studied, using human THP-1 cells that were differentiated to mature monocytes using vitamin D3. Addition of CHOS reduced the production of multiple pro-inflammatory cytokines associated with bacterial lipopolyssacharide (LPS)-stimulated inflammation, in a dose-dependent manner and without affecting cell viability. Interestingly, only minimal effects of CHOS were observed in similar experiments with phorbol 12-myristate 13-acetate- (PMA-) differentiated, macrophage-like, THP-1 cells. Altogether, in addition to showing promising biological effects of well-characterized low molecular weight soluble CHOS in a human system, the present study also points at Vitamin D3-stimulated THP-1 cells as a favorable system for assessing the anti-inflammatory activity of bioactive compounds.

Preparation of low-molecular-weight polyguluronate sulfate and its anticoagulant and anti-inflammatory activities

2007 ◽  
Vol 69 (2) ◽  
pp. 272-279 ◽  
Author(s):  
Xia Zhao ◽  
Guangli Yu ◽  
Huashi Guan ◽  
Nan Yue ◽  
Zhenqing Zhang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Anti Inflammatory ◽  
Polyguluronate Sulfate
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