Studies on the effects ofl(αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) on 4-aminophenol-induced nephrotoxicity in the Fischer 344 rat

1993 ◽  
Vol 67 (10) ◽  
pp. 696-705 ◽  
Author(s):  
Maria L. Anthony ◽  
Christopher R. Beddell ◽  
John C. Lindon ◽  
Jeremy K. Nicholson
Keyword(s):  
Fischer 344 ◽  
Fischer 344 Rat

Effects of a primary immune response to T-cell dependent antigen on serotonin metabolism in frontal cortex: in vivo microdialysis study in freely moving Fischer 344 rat

1994 ◽  
Vol 645 (1-2) ◽  
pp. 150-156 ◽  
Author(s):  
Alain M. Gardier ◽  
Sébastien Kachaner ◽  
Elisabeth Khan Shaghaghi ◽  
Christian Blot ◽  
Claude Bohuon ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
In Vivo Microdialysis ◽  
Primary Immune Response ◽  
Serotonin Metabolism ◽  
Fischer 344 ◽  
Fischer 344 Rat ◽  
Freely Moving ◽  
Microdialysis Study

Changes in phase I and phase II biotransformation with age in male Fischer 344 rat colon: Relationship to colon carcinogenesis

1987 ◽  
Vol 36 (3) ◽  
pp. 273-282 ◽  
Author(s):  
Timothy F. McMahon ◽  
William P. Beierschmitt ◽  
Myron Weiner
Keyword(s):  
Phase I ◽  
Phase Ii ◽  
Colon Carcinogenesis ◽  
Rat Colon ◽  
Fischer 344 ◽  
Fischer 344 Rat

As the gut ages: Timetables for aging of innervation vary by organ in the Fischer 344 rat

2001 ◽  
Vol 434 (3) ◽  
pp. 358-377 ◽  
Author(s):  
Robert J. Phillips ◽  
Terry L. Powley
Keyword(s):  
Fischer 344 ◽  
Fischer 344 Rat

Dermal absorption of neat and aqueous volatile organic chemicals in the fischer 344 rat

1991 ◽  
Vol 55 (1) ◽  
pp. 51-63 ◽  
Author(s):  
D.L. Morgan ◽  
S.W. Cooper ◽  
D.L. Carlock ◽  
J.J. Sykora ◽  
B. Sutton ◽  
...  
Keyword(s):  
Dermal Absorption ◽  
Organic Chemicals ◽  
Fischer 344 ◽  
Fischer 344 Rat ◽  
Volatile Organic ◽  
Volatile Organic Chemicals

Spontaneous Complex Pheochromocytoma in a Fischer 344 Rat

2001 ◽  
Vol 38 (4) ◽  
pp. 470-473 ◽  
Author(s):  
M. J. Martinez ◽  
S. R. Mog
Keyword(s):  
Fischer 344 ◽  
Fischer 344 Rat

Induction of c-jun and TGF-β1 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis

2001 ◽  
Vol 281 (5) ◽  
pp. L1180-L1188 ◽  
Author(s):  
William H. Chung ◽  
Brian M. Bennett ◽  
William J. Racz ◽  
James F. Brien ◽  
Thomas E. Massey
Keyword(s):  
Pulmonary Fibrosis ◽  
Protein Expression ◽  
Pulmonary Toxicity ◽  
Transforming Growth Factor ◽  
Fischer 344 Rats ◽  
Intratracheal Administration ◽  
Fischer 344 ◽  
Fischer 344 Rat ◽  
Mrna And Protein Expression ◽  
Tgf Β1

Amiodarone (AM) is an antidysrhythmic agent with a propensity to cause pulmonary toxicity, including potentially fatal fibrosis. In the present study, the potential roles of c-Jun and transforming growth factor (TGF)-β1 in AM-induced inflammation and fibrogenesis were examined after intratracheal administration of AM (1.83 μmol/day on days 0 and 2) or an equivalent volume (0.4 ml) of distilled water to male Fischer 344 rats. Northern and immunoblot analyses demonstrated that lung TGF-β1 (mRNA and protein) expression was increased 1.5- to 1.8-fold relative to control during the early inflammation period and 1 day, 1 wk, and 2 wk post-AM treatment. Lung c-Jun protein expression was increased concomitantly with evidence of AM-induced fibrosis; at 5 wk post-AM treatment, c-Jun protein was increased 3.3-fold relative to control. The results indicate a role for induction of c- jun and TGF-β1 expression in the development of AM-induced pulmonary fibrosis in the Fischer 344 rat and provide potential targets for therapeutic intervention.

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