Determination of diamine oxidase (histaminase) activity. An interference of aldehyde metabolizing enzymes

1978 ◽  
Vol 8 (4) ◽  
pp. 388-389 ◽  
Author(s):  
A. Fogel ◽  
T. Biegański ◽  
J. Wozniak ◽  
Cz. Máslinski
Keyword(s):  
Diamine Oxidase ◽  
Metabolizing Enzymes ◽  
Histaminase Activity

Interference of aldehyde metabolizing enzymes with diamine oxidase/histaminase/activity as determined by 14C putrescine method

1978 ◽  
Vol 27 (8) ◽  
pp. 1159-1162 ◽  
Author(s):  
Wieslawa Agnieszka Fogel ◽  
Tadeusz Biegański ◽  
Janina Woz'niak ◽  
Czeslaw Maśliński
Keyword(s):  
Diamine Oxidase ◽  
Metabolizing Enzymes ◽  
Histaminase Activity

scholarly journals DETERMINATION OF HISTAMINASE ACTIVITY IN HISTOLOGIC SAMPLES AND ITS QUANTITATIVE DISTRIBUTION IN INTACT HUMAN PLACENTA AND UTERUS

1967 ◽  
Vol 15 (8) ◽  
pp. 431-435 ◽  
Author(s):  
RONALD E. GUNTHER ◽  
DAVID GLICK
Keyword(s):  
Human Placenta ◽  
Diamine Oxidase ◽  
Enzymatic Oxidation ◽  
Optimal Conditions ◽  
Rat Stomach ◽  
Stomach Mucosa ◽  
Tissue Sections ◽  
Peritoneal Mast Cells ◽  
Histaminase Activity

The spectrophotometric method for determination of histaminase, based on measurement of the hydrogen peroxide formed by the enzymatic oxidation of histamine, was modified and adapted to studies on microliter volumes of tissue (placenta) homogenates and microtome sections of tissue (human uterus and attached intact placenta at term). Optimal conditions for these assays were established. From analyses of tissue sections, peak enzyme activities were observed in the decidua, thus supporting the concept that this tissue is a significant source of the increased enzyme in blood plasma during pregnancy in the human. Inhibitor studies with aminoguanidine sulfate showed that the histaminase investigated in the human placenta was diamine oxidase. No histaminase activity was detected in isolated peritoneal mast cells from the rat or in homogenates of rat stomach mucosa.

Endocrine evaluation

2011 ◽  
pp. 1363-1368
Author(s):  
Hermann M. Behre ◽  
Eberhard Nieschlag
Keyword(s):  
Sertoli Cells ◽  
Sexual Differentiation ◽  
Androgen Receptors ◽  
Follicle Stimulating Hormone ◽  
Laboratory Diagnosis ◽  
Stimulation Test ◽  
Metabolizing Enzymes ◽  
Testicular Dysfunction ◽  
Target Organs

The main constituent of endocrine laboratory diagnosis of testicular dysfunction is the determination of the gonadotropins, luteinizing hormone and follicle-stimulating hormone (FSH) secreted from the pituitary gland, of testosterone secreted from the Leydig cells, and of inhibin-B secreted from the Sertoli cells. Where hypothalamic or pituitary disorders are suspected as causes of testicular dysfunction, a gonadotropin-releasing hormone (GnRH) stimulation test can be performed for further differentiation. A human chorionic gonadotropin (hCG) stimulation test is done for evaluation of the endocrine reserve capacity of the testis. Additional hormone measurements are performed for special diagnostic questions, e.g. of oestradiol in cases of gynaecomastia, or hCG and oestradiol upon suspicion of a testicular tumour. Various steroid hormones, including dihydrotestosterone, androgen receptors, or androgen metabolizing enzymes (e.g. 5α‎-reductase) in the target organs are analysed in patients with disturbances of sexual differentiation.

scholarly journals Acute Kidney Injury Pharmacokinetic Changes and Its Impact on Drug Prescription

Healthcare ◽  
2019 ◽  
Vol 7 (1) ◽  
pp. 10 ◽  
Author(s):  
Victoria Blanco ◽  
Carolina Hernandorena ◽  
Paula Scibona ◽  
Waldo Belloso ◽  
Carlos Musso
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Function ◽  
Drug Prescription ◽  
Kidney Injury ◽  
Drug Dosage ◽  
Tubular Secretion ◽  
Metabolizing Enzymes ◽  
Drug Concentrations ◽  
The Impact

Acute kidney injury (AKI) is a common problem in hospitalized patients that is associated with significant morbid-mortality. The impact of kidney disease on the excretion of drugs eliminated by glomerular filtration and tubular secretion is well established, as well as the requirement for drug dosage adjustment in impaired kidney function patients. However, since impaired kidney function is associated with decreased activity of several hepatic and gastrointestinal drug-metabolizing enzymes and transporters, drugs doses adjustment only based on kidney alteration could be insufficient in AKI. In addition, there are significant pharmacokinetics changes in protein binding, serum amino acid levels, liver, kidney, and intestinal metabolism in AKI, thus the determination of plasma drug concentrations is a very useful tool for monitoring and dose adjustment in AKI patients. In conclusion, there are many pharmacokinetics changes that should be taken into account in order to perform appropriate drug prescriptions in AKI patients.

Temporary suppression of diamine oxidase (histaminase) activity by cysteamine

1962 ◽  
Vol 11 (7) ◽  
pp. 509-514 ◽  
Author(s):  
C. De Marco ◽  
B. Mondoví ◽  
D. Cavallini
Keyword(s):  
Diamine Oxidase ◽  
Histaminase Activity

Usefulness of Postmortem Determination of Serum Histamine, Diamine Oxidase and Tryptase in the Diagnosis of Fatal Anaphylaxis

2008 ◽  
Vol 121 (2) ◽  
pp. S27-S27
Author(s):  
R JARISCH ◽  
A KRAUSKOPF ◽  
K MORITZ ◽  
F WANTKE ◽  
G SESZTAKGREINECKER ◽  
...  
Keyword(s):  
Diamine Oxidase ◽  
Fatal Anaphylaxis

Pitfalls in the determination of diamine oxidase activity

1991 ◽  
Vol 201 (1-2) ◽  
pp. 89-94
Author(s):  
Catherine H. Smith ◽  
Mehran Maghsoudloo ◽  
Kazuo Himuna ◽  
Gerard M. Murphy
Keyword(s):  
Oxidase Activity ◽  
Diamine Oxidase ◽  
Diamine Oxidase Activity
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