Antiinflammatory, analgesic, and antipyretic activities of methyl 7-butyl-4,5,6,7-tetrahydro-3-methylamino-4,6-dioxo-5-propyl-2H-pyrazolo[3,4-d]pyrimidine-2-carboxylate (AA-2379), a novel non-acidic agent

1988 ◽  
Vol 25 (3-4) ◽  
pp. 385-393 ◽  
Author(s):  
H. Makino ◽  
S. Kuzuna ◽  
T. Naka ◽  
T. Saijo ◽  
Y. Maki
Keyword(s):  
Acidic Agent

scholarly journals Saccharin: a cheap and mild acidic agent for the synthesis of azo dyes via telescoped dediazotization

2019 ◽  
Vol 8 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Nader Ghaffari Khaligh ◽  
Mohd Rafie Johan ◽  
Juan Joon Ching
Keyword(s):  
Cost Effectiveness ◽  
Azo Dyes ◽  
Coupling Reaction ◽  
Current Method ◽  
Environmentally Benign ◽  
Synthesis Methods ◽  
Interesting Aspect ◽  
Experimental Procedure ◽  
Acidic Agent ◽  
First Time

Abstract Green synthesis methods are considered as a safer alternative to the conventional synthetic processes due to their eco-friendly nature, cost-effectiveness, and easy handling. In the present study, an eco-friendly and sustainable method for the synthesis of stable arenediazonium has been developed using saccharin as a cheap and mild acidic agent and tert-butyl nitrite as a diazotization reagent for the first time. These stable intermediates were used in the azo coupling reaction with 4-hydroxybenzaldehyde via telescoped dediazotization. The current method has advantages such as reduced waste by avoiding solvent for the purification of intermediate in diazotization step, cost-effectiveness, simple experimental procedure, good yield of azo dyes, metal-free waste, and environmentally benign conditions. An interesting aspect of this study is the recovery of saccharin from the reaction, which could be reused.

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