Action of imidazole and some of its derivatives on nerve-muscle transmission in frog

1974 ◽  
Vol 4 (5) ◽  
pp. 404-409 ◽  
Author(s):  
Z. Korsak ◽  
R. S. Tuttle ◽  
Cz. Maśliński
Keyword(s):  
Nerve Muscle

Nerve-Muscle Interaction

1979 ◽  
Vol 7 (5) ◽  
pp. 1169-1169
Author(s):  
S. WONNACOTT
Keyword(s):  
Nerve Muscle

Application and Evaluation of Case-Based Learning as a Part of Early Clinical Exposure for Undergraduate Medical Education Program

2020 ◽  
Vol 5 (08) ◽  
pp. 284-288
Author(s):  
Vandana Daulatabad ◽  
Prafull K. ◽  
Dr. Surekha S. Kadadi-Patil ◽  
Ramesh S. Patil
Keyword(s):  
Medical Education ◽  
Research Centre ◽  
Muscle Physiology ◽  
Case Scenario ◽  
Clinical Exposure ◽  
Clinical Scenarios ◽  
Case Based Learning ◽  
Nerve Muscle ◽  
Case Based ◽  
Early Clinical Exposure

Introduction: Medical Education is witnessing a significant transition and global shift towards competency based medical education (CBME) which includes early clinical exposure (ECE) program to help students apply and correlate principles of preclinical subjects with clinical scenarios, in various forms and in a variety of settings. One of the easy and feasible methods of ECE being Case Based Learning (CBL), our study aimed to design a case scenario and to evaluate impact of case base learning as a part of ECE module in first year undergraduate medical teaching program in nerve muscle physiology. Methods: The present study was conducted in 96 students at Ashwini Rural Medical College Hospital and Research Centre, Solapur after obtaining institutional ethics committee approval. 3 hrs session of CBL was conducted for a case scenario on myasthenia gravis in the nerve muscle physiology module. The students’ responses on pre-test, post-test and their insights regarding the CBL were taken through a pre validated questionnaire using 5-point Likert scale. Results: High impact of CBL was seen as significant improvement in student’s performance. Maximum students felt CBL to be easy method of learning and was highly appreciated through their feedback. Conclusion: CBL was found to have positive impact on understanding and perception of topic. CBL helped students to understand, evaluate, analyze, diagnose and interpret the case, paving them towards newer approach of self-directed and vertical integrated learning. CBL is easier, feasible an effective method among other early clinical exposure methods as it involves students in deeper and self-directed active learning, encouraging and promoting them to reach higher levels of cognitive domain of Bloom’s taxonomy. This method will be very useful in its practical implementation during online classes for ECE module in the threat of COVID 19 situation as well.

Role of Muscle Activity in Nerve-Muscle Interaction in vitro

Nature ◽  
1974 ◽  
Vol 248 (5443) ◽  
pp. 70-71 ◽  
Author(s):  
J. H. STEINBACH
Keyword(s):  
Muscle Activity ◽  
Nerve Muscle

Effects of Nerve-Muscle Pedicle on Immobile Rat Vocal Folds in the Presence of Partial Innervation

2010 ◽  
Vol 119 (12) ◽  
pp. 823-829 ◽  
Author(s):  
Takashi Aoyama ◽  
Yoshihiko Kumai ◽  
Eiji Yumoto ◽  
Takaaki Ito ◽  
Satoru Miyamaru
Keyword(s):  
Vocal Folds ◽  
Nerve Muscle

Effect of armin on synaptic transmission in the frog nerve-muscle preparation

1981 ◽  
Vol 91 (6) ◽  
pp. 774-777 ◽  
Author(s):  
I. I. Krivoi ◽  
V. I. Kuleshov ◽  
D. P. Matyushkin ◽  
V. I. Sanotskii ◽  
I. A. Shabunova
Keyword(s):  
Synaptic Transmission ◽  
Muscle Preparation ◽  
Nerve Muscle

Effects Of Doxycycline On Mice Neuromuscular Junction, In Situ

2021 ◽  
Vol 21 ◽  
Author(s):  
Natália Tribuiani ◽  
Jocimar de Souza ◽  
Marcos Antônio de Queiroz Junior ◽  
Denicezar Angelo Baldo ◽  
Valéria de Campos Orsi ◽  
...  
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Synaptic Cleft ◽  
Diaphragm Muscle ◽  
Na Channel ◽  
Muscle Histology ◽  
Casearia Sylvestris ◽  
Nerve Muscle ◽  
Neuromuscular Preparation

Background: The antibacterial mechanism of doxycycline is known, but on the nerve-muscle apparatus is yet unclear. Objective: To combine molecular targets of the neuromuscular machinery using the neuronal blocker effect doxycycline, a semisynthetic second-generation tetracycline derivative, on mice neuromuscular preparations, in situ. Methods: Doxycycline was assessed at the neurotransmission; presynaptic; synaptic cleft; and postsynaptic, including the muscle fiber, using the traditional myographic technique. Preliminarily, doxycycline showed an "all or nothing" effect, being "all" obtained with 4 µM and "nothing", with 1-3 µM. The rationale of this study was to apply known pharmacological tools against the blocker effect of 4 µM doxycycline such as F55-6 (Casearia sylvestris), CaCl2 (or Ca2+), atropine, neostigmine, polyethylene glycol (PEG 400), and d-Tubocurarine. The evaluation of cholinesterase enzyme activity, the diaphragm muscle histology, and protocols on the neuromuscular preparation submitted to indirect or direct stimuli were complementary. Results: Doxycycline does not affect cholinesterase activity nor cause damage to skeletal muscle diaphragm; acts on ryanodine receptor, sarcolemmal membrane, and on neuronal sodium channel with a postjunctional consequence due to the decreased availability of muscle nicotinic acetylcholine receptors. Conclusions: In conclusion, using the blocker effect we showed that doxycycline acts on multiple targets, among them, is antagonized by F55-6, a neuronal Na+-channel agonist and Ca2+, but not by neostigmine.

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