Pharmacological studies of a new analgesic, dl-erythro-1-phenyl-2-(o-chlorophenyl)-2-[4-(p-methoxybenzyl)-1-piperazinyl] ethanol dihydrochloride, in experimental animals

1979 ◽  
Vol 35 (3) ◽  
pp. 369-370
Author(s):  
H. Nakamura ◽  
K. Ishii ◽  
Y. Yokoyama ◽  
S. Motoyoshi ◽  
C. Imazu ◽  
...  
Keyword(s):  
Experimental Animals ◽  
Pharmacological Studies

Pharmacological Studies on the Antithrombotic Action of Hirudin in Experimental Animals

1982 ◽  
Vol 47 (03) ◽  
pp. 226-229 ◽  
Author(s):  
F Markwardt ◽  
J Hauptmann ◽  
G Nowak ◽  
Ch Kleßen ◽  
P Walsmann
Keyword(s):  
Venous Thrombosis ◽  
Intravenous Injection ◽  
Disseminated Intravascular Coagulation ◽  
Active Form ◽  
Biologically Active ◽  
Half Time ◽  
Experimental Animals ◽  
Shunt Occlusion ◽  
Pharmacological Studies ◽  
Low Toxicity

SummaryThe pharmacodynamics and pharmacokinetics of hirudin were studied in dogs, rabbits and rats. Hirudin proved to be a well tolerated substance with low toxicity. After intravenous injection it was eliminated with a half time of 50 to 60 min. It was nearly completely excreted through the kidneys in biologically active form. The efficacy of hirudin in preventing venous thrombosis, vascular shunt occlusion and disseminated intravascular coagulation in rats was demonstrated.

scholarly journals GENERAL PHARMACOLOGICAL STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN EXPERIMENTAL ANIMALS

1985 ◽  
Vol 10 (SupplementII) ◽  
pp. 129-146 ◽  
Author(s):  
Noboru HOSHI ◽  
Koichi UENO ◽  
Hiroko YANO ◽  
Kaoru HIRASHIMA ◽  
Haruo KITAGAWA
Keyword(s):  
Experimental Animals ◽  
Pharmacological Studies

Analytical Electron Microscopy (AEM) of Meningeal Cells Exposed to Particulate Cobalt During Studies of Experimental Epilepsy

1982 ◽  
Vol 40 ◽  
pp. 186-187
Author(s):  
R.G. Frederickson ◽  
R.G. Ulrich ◽  
J.L. Culberson
Keyword(s):  
Electron Microscopy ◽  
Analytical Electron Microscopy ◽  
Experimental Epilepsy ◽  
Metallic Cobalt ◽  
Experimental Animals ◽  
X Ray ◽  
Brain Surface ◽  
Meningeal Cells ◽  
Analytical Electron ◽  
The Brain

Metallic cobalt acts as an epileptogenic agent when placed on the brain surface of some experimental animals. The mechanism by which this substance produces abnormal neuronal discharge is unknown. One potentially useful approach to this problem is to study the cellular and extracellular distribution of elemental cobalt in the meninges and adjacent cerebral cortex. Since it is possible to demonstrate the morphological localization and distribution of heavy metals, such as cobalt, by correlative x-ray analysis and electron microscopy (i.e., by AEM), we are using AEM to locate and identify elemental cobalt in phagocytic meningeal cells of young 80-day postnatal opossums following a subdural injection of cobalt particles.

Ultrastructure and analytical microprobe analysis of simian lung mite pigments

1986 ◽  
Vol 44 ◽  
pp. 324-325
Author(s):  
R. W. Cole ◽  
J. C. Kim
Keyword(s):  
Biomedical Research ◽  
Tissue Damage ◽  
Microprobe Analysis ◽  
Old World Monkeys ◽  
Old World ◽  
Experimental Animals ◽  
The Past ◽  
Lung Mite ◽  
Mite Infestations ◽  
Cardiopulmonary System

In recent years, non-human primates have become indispensable as experimental animals in many fields of biomedical research. Pharmaceutical and related industries alone use about 2000,000 primates a year. Respiratory mite infestations in lungs of old world monkeys are of particular concern because the resulting tissue damage can directly effect experimental results, especially in those studies involving the cardiopulmonary system. There has been increasing documentation of primate parasitology in the past twenty years.

The Effect of ACTH on Gastric Secretion in Experimental Animals

1952 ◽  
Vol 21 (2) ◽  
pp. 276-279 ◽  
Author(s):  
Jose M. Zubiran ◽  
Allan E. Kark ◽  
Lester R. Dragstedt
Keyword(s):  
Gastric Secretion ◽  
Experimental Animals
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