Structural alterations in rat kidney proximal tubules perfused with fresh autologous serum

1983 ◽  
Vol 39 (4) ◽  
pp. 394-396 ◽  
Author(s):  
K. Sato ◽  
C. J. Bentzel
Keyword(s):  
Rat Kidney ◽  
Proximal Tubules ◽  
Autologous Serum ◽  
Structural Alterations ◽  
Kidney Proximal Tubules

Ouabain-insensitive, Na-ATPase activity in pure suspensions of rat kidney proximal tubules

FEBS Letters ◽  
1990 ◽  
Vol 269 (1) ◽  
pp. 77-78 ◽  
Author(s):  
Reinaldo Marín ◽  
Daniela C. Gómez ◽  
Gloria A. Rodríguez ◽  
Teresa Proverbio ◽  
Fulgencio Proverbio
Keyword(s):  
Atpase Activity ◽  
Rat Kidney ◽  
Proximal Tubules ◽  
Kidney Proximal Tubules

Impairment of lysosome-pinocytic vesicle fusion in rat kidney proximal tubules after treatment with gentamicin at low doses

1986 ◽  
Vol 86 (2) ◽  
pp. 271-285 ◽  
Author(s):  
L. Giurgea-Marion ◽  
G. Toubeau ◽  
G. Laurent ◽  
J.A. Heuson-Stiennon ◽  
P.M. Tulkens
Keyword(s):  
Rat Kidney ◽  
Vesicle Fusion ◽  
Proximal Tubules ◽  
Low Doses ◽  
Kidney Proximal Tubules

scholarly journals Identification of a new gene product (diphor-1) regulated by dietary phosphate

1997 ◽  
Vol 273 (5) ◽  
pp. F801-F806 ◽  
Author(s):  
María Custer ◽  
Benjamin Spindler ◽  
François Verrey ◽  
Heini Murer ◽  
Jürg Biber
Keyword(s):  
Cellular Response ◽  
Rat Kidney ◽  
Proximal Tubules ◽  
Kidney Cortex ◽  
Rat Kidney Cortex ◽  
Reading Frame ◽  
New Gene ◽  
High Degree ◽  
The Impact ◽  
Kidney Proximal Tubules

Chronic restriction of dietary Pi elicits an increased reabsorption of Pi in the kidney proximal tubules, which involves a stimulation of apical Na-Pi cotansport. This adaptation is in part a direct cellular response of which the mechanism(s) are poorly understood. In this study, the impact of dietary Pi restriction on the differential expression of rat kidney cortex mRNAs was visualized to identify gene products regulated by the Pistatus. When kidney cortex mRNAs of rats fed a low- or a high-Pi diet were compared by differential display-polymerase chain reaction (DD-PCR), thirty modulated cDNA bands were observed, of which four were confirmed as being regulated. We focused on one of the upregulated bands, dietary Pi-regulated RNA-1 (diphor-1). A cDNA containing an open reading frame encoding a 52-kDa protein was cloned by library screening. Diphor-1 exhibits a high degree of identity to the Na/H exchanger regulatory factor and to a tyrosine kinase activating protein. Highest expression of diphor-1 mRNA was detected in the kidney (proximal tubules) and in small intestine. Expression experiments showed that diphor-1 specifically increases Na-Picotransport in oocytes of Xenopus laevis coinjected with renal type II Na-Pi cotransporter cRNA. Further characterizations of diphor-1 will show whether diphor-1 is primarily or secondarily involved in the response to dietary Pi.

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