Effect of niacin/nicotinamide deficiency on the diabetogenic effect of streptozotocin

1988 ◽  
Vol 44 (1) ◽  
pp. 38-40 ◽  
Author(s):  
J. R. Wright ◽  
J. Mendola ◽  
P. E. Lacy
Keyword(s):  
Nicotinamide Deficiency

Nicotinamide Deficiency after Oral Penicillin

BMJ ◽  
1946 ◽  
Vol 2 (4477) ◽  
pp. 611-613 ◽  
Author(s):  
P. Ellinger ◽  
F. M. Shattock
Keyword(s):  
Oral Penicillin ◽  
Nicotinamide Deficiency

Nicotinamide Deficiency and Gingivitis

BMJ ◽  
1945 ◽  
Vol 1 (4389) ◽  
pp. 234-235
Author(s):  
J. D. King
Keyword(s):  
Nicotinamide Deficiency

scholarly journals Prevention and Remission by Adrenocortical Steroids of Nicotinamide Deficiency Disease

1968 ◽  
Vol 243 (16) ◽  
pp. 4216-4221 ◽  
Author(s):  
P Greengard ◽  
H Kalinsky ◽  
T J Manning ◽  
S B Zak
Keyword(s):  
Deficiency Disease ◽  
Nicotinamide Deficiency

scholarly journals Nicotinamide and Demographic and Disease transitions: Moderation is Best

2019 ◽  
Vol 12 ◽  
pp. 117864691985594
Author(s):  
Adrian C Williams ◽  
Lisa J Hill
Keyword(s):  
T Helper Cells ◽  
Genetic Background ◽  
Optimal Dose ◽  
Good Health ◽  
Rapid Progress ◽  
T Helper ◽  
Environmental Enteropathy ◽  
Acute Infections ◽  
Nicotinamide Deficiency ◽  
Fertility Genes

Good health and rapid progress depend on an optimal dose of nicotinamide. Too little meat triggers the neurodegenerative condition pellagra and tolerance of symbionts such as tuberculosis (TB), risking dysbioses and impaired resistance to acute infections. Nicotinamide deficiency is an overlooked diagnosis in poor cereal-dependant economies masquerading as ‘environmental enteropathy’ or physical and cognitive stunting. Too much meat (and supplements) may precipitate immune intolerance and autoimmune and allergic disease, with relative infertility and longevity, via the tryptophan-nicotinamide pathway. This switch favours a dearth of regulatory T (Treg) and an excess of T helper cells. High nicotinamide intake is implicated in cancer and Parkinson’s disease. Pro-fertility genes, evolved to counteract high-nicotinamide-induced infertility, may now be risk factors for degenerative disease. Moderation of the dose of nicotinamide could prevent some common diseases and personalised doses at times of stress or, depending on genetic background or age, may treat some other conditions.

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