The fine structure of cloned cells from normal adult rat brain

1980 ◽  
Vol 36 (2) ◽  
pp. 194-196 ◽  
Author(s):  
G. J. Pilkington ◽  
P. L. Lantos ◽  
J. P. Roscoe
Keyword(s):  
Fine Structure ◽  
Rat Brain ◽  
Normal Adult ◽  
Adult Rat ◽  
Adult Rat Brain

Glial cells from normal adult rat brain established in continuous culture

1978 ◽  
Vol 155 (2) ◽  
pp. 418-421 ◽  
Author(s):  
Vijendra K. Singh ◽  
Diane Van Alstyne
Keyword(s):  
Continuous Culture ◽  
Rat Brain ◽  
Glial Cells ◽  
Normal Adult ◽  
Adult Rat ◽  
Adult Rat Brain

Expression of Neuronal Proteins in Cells from Normal Adult Rat Brain Propagated in Serial Culture

2008 ◽  
Vol 62 (6) ◽  
pp. 2132-2140 ◽  
Author(s):  
Ronald S. Black ◽  
Lorraine A. DeGiorgio ◽  
Kwan-Fu Rex Sheu ◽  
Zbigniew Darzynkiewicz ◽  
Janet T. Duffy ◽  
...  
Keyword(s):  
Rat Brain ◽  
Normal Adult ◽  
Adult Rat ◽  
Adult Rat Brain ◽  
Neuronal Proteins ◽  
In Cells

Immunocytochemical characterization of cloned cells from normal adult rat brain

1983 ◽  
Vol 42 (2) ◽  
pp. 213-218 ◽  
Author(s):  
Geoffrey J. Pilkington ◽  
David A. Smith ◽  
Peter L. Lantos
Keyword(s):  
Rat Brain ◽  
Normal Adult ◽  
Adult Rat ◽  
Adult Rat Brain

scholarly journals Monoubiquitination and Cellular Distribution of XIAP in Neurons after Traumatic Brain Injury

2003 ◽  
Vol 23 (10) ◽  
pp. 1129-1136 ◽  
Author(s):  
George Lotocki ◽  
Ofelia F Alonso ◽  
Beata Frydel ◽  
W Dalton Dietrich ◽  
Robert W Keane
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Rat Brain ◽  
Brain Regions ◽  
Normal Adult ◽  
Normal Brain ◽  
Adult Rat ◽  
Moderate Traumatic Brain Injury ◽  
Adult Rat Brain ◽  
Specific Regulation

XIAP is a member of the inhibitor of apoptosis (IAP) gene family that, in addition to suppressing cell death by inhibition and polyubiquitination of caspases, is involved in an increasing number of signaling cascades. Moreover, the function and regulation of XIAP in the central nervous system (CNS) is poorly understood. In this study, the authors investigated the cell-type expression, the subcellular distribution, ubiquitination of XIAP, and levels of Smac/DIABLO in the normal adult rat brain and in brains subjected to moderate traumatic brain injury (TBI). In the normal brain, XIAP was predominantly expressed in the perinuclear region of neurons. Traumatized brains showed dramatic alterations in cellular and regional expression of XIAP early after injury. Stereologic analyses of the number of XIAP-positive cells within the hippocampus of both hemispheres showed a biphasic response. Immunoprecipitation and immunoblots of extracts derived from different brain regions demonstrated that a single ubiquitin modifies XIAP. Normal cortex contained significantly higher levels of monoubiquitinated XIAP than hippocampus. TBI induced alterations in levels of monoubiquitinated XIAP that correlated with changes in XIAP distribution and immunoreactivity, suggesting that monoubiquitination of XIAP may be a regulator of XIAP location or activity. Similar levels of Smac/DIABLO were present in lysates of normal and traumatized brains. These data demonstrate for the first time a region-specific regulation of XIAP monoubiquitination in the normal adult rat brain, and after TBI, that may be a key event in the regulation of XIAP function contributing to the pathogenesis following injury.

scholarly journals Differential Expression of PTEN in Normal Adult Rat Brain and Upregulation of PTEN and p-Akt in the Ischemic Cerebral Cortex

2009 ◽  
Vol 292 (4) ◽  
pp. 498-512 ◽  
Author(s):  
Qi-Yan Cai ◽  
Xing-Shu Chen ◽  
Shan-Chuan Zhong ◽  
Xue Luo ◽  
Zhong-Xiang Yao
Keyword(s):  
Cerebral Cortex ◽  
Rat Brain ◽  
Differential Expression ◽  
Normal Adult ◽  
Adult Rat ◽  
Adult Rat Brain
Sign in / Sign up

Export Citation Format

Share Document