Current problems in smooth muscle mechanics

1985 ◽  
Vol 41 (8) ◽  
pp. 1017-1020 ◽  
Author(s):  
B. Johansson
Keyword(s):  
Smooth Muscle ◽  
Muscle Mechanics ◽  
Smooth Muscle Mechanics

Decreased PO2 and Rabbit Aortic Smooth Muscle Mechanics

1995 ◽  
Vol 32 (5) ◽  
pp. 313-319 ◽  
Author(s):  
Roberts S. Moreland ◽  
Ronald F. Coburn ◽  
Suzanne Moreland
Keyword(s):  
Smooth Muscle ◽  
Muscle Mechanics ◽  
Aortic Smooth Muscle ◽  
Smooth Muscle Mechanics

scholarly journals Smooth Muscle Mechanics: Implications for Airway Hyperresponsiveness

1991 ◽  
Vol 94 (1-4) ◽  
pp. 291-292 ◽  
Author(s):  
R.R. Schellenberg ◽  
P.D. Pare ◽  
J. Hards ◽  
K. Ishida
Keyword(s):  
Smooth Muscle ◽  
Airway Hyperresponsiveness ◽  
Muscle Mechanics ◽  
Smooth Muscle Mechanics

Vascular smooth muscle mechanics in isolated perfused segments of carotid arteries

Surgery ◽  
2000 ◽  
Vol 127 (2) ◽  
pp. 148-154 ◽  
Author(s):  
Hilde Jerius ◽  
Charles A. Bagwell ◽  
Arthur Beall ◽  
Daniel Karolyi ◽  
Colleen Brophy
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Carotid Arteries ◽  
Muscle Mechanics ◽  
Smooth Muscle Mechanics

An expanded latch-bridge model of protein kinase C-mediated smooth muscle contraction

2005 ◽  
Vol 98 (4) ◽  
pp. 1356-1365 ◽  
Author(s):  
Chi-Ming Hai ◽  
Hak Rim Kim
Keyword(s):  
Smooth Muscle ◽  
Atpase Activity ◽  
Thin Filament ◽  
Muscle Mechanics ◽  
Smooth Muscle Contraction ◽  
Myosin Phosphorylation ◽  
Cross Bridge ◽  
Bridge Model ◽  
Cross Bridges ◽  
Smooth Muscle Mechanics

A thin-filament-regulated latch-bridge model of smooth muscle contraction is proposed to integrate thin-filament-based inhibition of actomyosin ATPase activity with myosin phosphorylation in the regulation of smooth muscle mechanics. The model included two latch-bridge cycles, one of which was identical to the four-state model as proposed by Hai and Murphy ( Am J Physiol Cell Physiol 255: C86–C94, 1988), whereas the ultraslow cross-bridge cycle has lower cross-bridge cycling rates. The model-fitted phorbol ester induced slow contractions at constant myosin phosphorylation and predicted steeper dependence of force on myosin phosphorylation in phorbol ester-stimulated smooth muscle. By shifting cross bridges between the two latch-bridge cycles, the model predicts that a smooth muscle cell can either maintain force at extremely low-energy cost or change its contractile state rapidly, if necessary. Depending on the fraction of cross bridges engaged in the ultraslow latch-bridge cycle, the model predicted biphasic kinetics of smooth muscle mechanics and variable steady-state dependencies of force and shortening velocity on myosin phosphorylation. These results suggest that thin-filament-based regulatory proteins may function as tuners of actomyosin ATPase activity, thus allowing a smooth muscle cell to have two discrete cross-bridge cycles with different cross-bridge cycling rates.

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