The effect of intracellular potassium ions on active sodium efflux in frog sartorius muscle

1973 ◽  
Vol 29 (7) ◽  
pp. 794-795 ◽  
Author(s):  
R. A. Chaplain
Keyword(s):  
Sartorius Muscle ◽  
Potassium Ions ◽  
Active Sodium ◽  
Sodium Efflux ◽  
Intracellular Potassium ◽  
Frog Sartorius Muscle ◽  
Frog Sartorius

scholarly journals Fractionation of Sodium Efflux in Frog Sartorius Muscles by Strophanthidin and Removal of External Sodium

1970 ◽  
Vol 55 (3) ◽  
pp. 401-425 ◽  
Author(s):  
P. Horowicz ◽  
J. W. Taylor ◽  
D. M. Waggoner
Keyword(s):  
Sodium Concentration ◽  
Sartorius Muscle ◽  
Complete Replacement ◽  
Sodium Efflux ◽  
Frog Sartorius Muscle ◽  
Initial Rise ◽  
Effects Of Temperature ◽  
Free Media ◽  
Frog Sartorius ◽  
Normal Ringer

The influence of strophanthidin, ouabain, and the removal of external sodium on the sodium efflux from frog sartorius muscle was measured. In freshly dissected muscles strophanthidin and ouabain in maximally effective concentrations reduced the efflux of sodium by about 50%. Of the sodium efflux which is strophanthidin-insensitive about 75% is inhibited after complete replacement of external sodium by lithium. In the absence of strophanthidin replacement of external sodium by lithium, calcium, or magnesium produces an initial rise in the sodium efflux, followed by a fall in the efflux as the exposure of the muscles to sodium-free media is continued. When the muscles are exposed for prolonged periods in sodium-free media, the fraction of internal sodium lost per minute is higher when returned to normal Ringer fluid than it was initially. The activation of sodium efflux by external sodium after long periods in sodium-free solutions is partly strophanthidin-sensitive and partly strophanthidin-insensitive. The internal sodium concentration is an important factor in these effects. The effects of temperature on the sodium efflux were also measured. Above 7°C the Q10 of both the strophanthidin-sensitive and strophanthidin-insensitive sodium efflux is about 2.0. Below 7°C the strophanthidin-insensitive sodium efflux has a Q10 of about 7.4.

Effect of dinitrophenol on phosphorylation and bioelectric phenomena of excitable tissues

1961 ◽  
Vol 200 (3) ◽  
pp. 431-436 ◽  
Author(s):  
L. G. Abood ◽  
K. Koketsu ◽  
K. Noda
Keyword(s):  
Energy Metabolism ◽  
Muscle Fibers ◽  
Resting Potential ◽  
Sartorius Muscle ◽  
Nerve Roots ◽  
Intracellular Potassium ◽  
Frog Sartorius Muscle ◽  
Anodal Polarization ◽  
Frog Sartorius

The effect of 2, 4-dinitrophenol (DNP) was investigated on the phosphorylation of frog sartorius muscle and ventral nerve roots, using P32 as a tracer. It was possible almost completely to inhibit phosphorylation without significantly altering excitability, although the resting potential and intracellular potassium decreased over 30%. The addition of 0.01 mm DNP to a sodium-free hydrazinium system completely blocked excitability, despite the fact that this concentration of DNP produced no further inhibition of phosphorylation. It was possible to restore the excitability of frog sartorius muscle fibers by anodal polarization after the fibers were rendered inexcitable by immersion in 1 mm DNP. The results were discussed in terms of the role of energy metabolism in excitability and other bioelectric phenomena of muscle and nerve.

Constancy of Axial Spacings in Frog Sartorius Muscle during Contraction

Nature ◽  
1965 ◽  
Vol 206 (4991) ◽  
pp. 1358-1358 ◽  
Author(s):  
H. E. HUXLEY ◽  
W. BROWN ◽  
K. C. HOLMES
Keyword(s):  
Sartorius Muscle ◽  
Frog Sartorius Muscle ◽  
Frog Sartorius
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