scholarly journals Effects of ethacrynic acid on ion transport and energy metabolism in slices of avian salt gland and of mammalian liver and kidney cortex

1978 ◽  
Vol 43 (2-3) ◽  
pp. 251-275 ◽  
Author(s):  
George D. V. van Rossum ◽  
Stephen A. Ernst
1975 ◽  
Vol 228 (3) ◽  
pp. 815-820 ◽  
Author(s):  
MW Weiner

ATPase activity of intact mitochondria may be induced by the presence of sodium. Mitochondria obtained from kidney cortex or medulla demonstrate a higher sodium-stimulated ATPase than mitochondria prepared from liver. This difference is not due to a greater capacity of kidney mitochondria for ATP hydrolysis. Sodium-stimulated ATPase activity of mitochondria is not further enhanced by magnesium or potassium, nor is it inhibited by ouabain. Furthermore, the ATPase of submitochondrial particles is not enhanced by the presence of sodium. These results indicate that the ATPase activity of mitochondria which is stimulated by sodium is unrelated to the microsomal Na-K-ATPase. mitochondrial sodium-stimulated ATPase is affected by pH, anionic composition, furosemide, and ethacrynic acid. The demonstration that mitochondrial ATP hydrolysis can be activated by sodium suggests that intracellular sodium may directly influence intracellular energy metabolism.


1984 ◽  
Vol 14 (1) ◽  
pp. 52-60 ◽  
Author(s):  
Masayuki Yamamoto ◽  
Yasuyuki Shimahara ◽  
Kazue Ozawa ◽  
Takayoshi Tobe ◽  
Wolf Isselhard

1979 ◽  
Vol 28 (23) ◽  
pp. 3385-3390 ◽  
Author(s):  
Richard T. Okita ◽  
Sten W. Jakobsson ◽  
Russell A. Prough ◽  
Bettie Sue Siler Masters

1981 ◽  
Vol 3 (1) ◽  
pp. 107-123 ◽  
Author(s):  
Wayne Crowe ◽  
Avraham Mayevsky ◽  
Leena Mela

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