The effect of a phorbol ester upon the cholinergic regulation of potassium permeability in the rat submandibular gland

1995 ◽  
Vol 51 (2) ◽  
pp. 110-112
Author(s):  
J. D. Pediani ◽  
S. M. Wilson
Keyword(s):  
Submandibular Gland ◽  
Phorbol Ester ◽  
Potassium Permeability ◽  
Cholinergic Regulation ◽  
Rat Submandibular Gland

Cytochemical Evidence for Presynatic β-Adrenergic Regulation of Secretion in the Developing Rat Submandibular Gland

1977 ◽  
Vol 35 ◽  
pp. 430-431
Author(s):  
L.S. Cutler
Keyword(s):  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Submandibular Gland ◽  
Neonatal Rat ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Parotid Glands ◽  
Adrenergic Agonist ◽  
Rat Submandibular Gland

Many studies previously have shown that the B-adrenergic agonist isoproterenol and the a-adrenergic agonist norepinephrine will stimulate secretion by the adult rat submandibular (SMG) and parotid glands. Recent data from several laboratories indicates that adrenergic agonists bind to specific receptors on the secretory cell surface and stimulate membrane associated adenylate cyclase activity which generates cyclic AMP. The production of cyclic AMP apparently initiates a cascade of events which culminates in exocytosis. During recent studies in our laboratory it was observed that the adenylate cyclase activity in plasma membrane fractions derived from the prenatal and early neonatal rat submandibular gland was retractile to stimulation by isoproterenol but was stimulated by norepinephrine. In addition, in vitro secretion studies indicated that these prenatal and neonatal glands would not secrete peroxidase in response to isoproterenol but would secrete in response to norepinephrine. In contrast to these in vitro observations, it has been shown that the injection of isoproterenol into the living newborn rat results in secretion of peroxidase by the SMG (1).

scholarly journals Potassium (86Rb+) efflux from the rat submandibular gland under sodium-free conditions in vitro.

1989 ◽  
Vol 416 (1) ◽  
pp. 503-515 ◽  
Author(s):  
D L Bovell ◽  
H Y Elder ◽  
J D Pediani ◽  
S M Wilson
Keyword(s):  
Submandibular Gland ◽  
Rat Submandibular Gland
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