Relation of the character of capacitance vessel responses in spleen and small intestine elicited by electrical stimulation of the sympathetic fibres to the level of oxygen exchange in the organs

1976 ◽  
Vol 32 (9) ◽  
pp. 1168-1170
Author(s):  
B. I. Tkachenko ◽  
P. K. Pozdnjakov ◽  
N. Ja. Medvedeva
Keyword(s):  
Small Intestine ◽  
Electrical Stimulation ◽  
Oxygen Exchange ◽  
Capacitance Vessel ◽  
Stimulation Of

scholarly journals Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine

2014 ◽  
Vol 307 (7) ◽  
pp. G719-G731 ◽  
Author(s):  
Guo-Du Wang ◽  
Xi-Yu Wang ◽  
Sumei Liu ◽  
Meihua Qu ◽  
Yun Xia ◽  
...  
Keyword(s):  
Nervous System ◽  
Mast Cell ◽  
Small Intestine ◽  
Electrical Stimulation ◽  
Mast Cells ◽  
Guinea Pig ◽  
Mast Cell Protease ◽  
Human Small Intestine ◽  
Neurokinin 1 ◽  
Stimulation Of

Mast cells express the substance P (SP) neurokinin 1 receptor and the calcitonin gene-related peptide (CGRP) receptor in guinea pig and human small intestine. Enzyme-linked immunoassay showed that activation of intramural afferents by antidromic electrical stimulation or by capsaicin released SP and CGRP from human and guinea pig intestinal segments. Electrical stimulation of the afferents evoked slow excitatory postsynaptic potentials (EPSPs) in the enteric nervous system. The slow EPSPs were mediated by tachykinin neurokinin 1 and CGRP receptors. Capsaicin evoked slow EPSP-like responses that were suppressed by antagonists for protease-activated receptor 2. Afferent stimulation evoked slow EPSP-like excitation that was suppressed by mast cell-stabilizing drugs. Histamine and mast cell protease II were released by 1) exposure to SP or CGRP, 2) capsaicin, 3) compound 48/80, 4) elevation of mast cell Ca2+ by ionophore A23187, and 5) antidromic electrical stimulation of afferents. The mast cell stabilizers cromolyn and doxantrazole suppressed release of protease II and histamine when evoked by SP, CGRP, capsaicin, A23187, electrical stimulation of afferents, or compound 48/80. Neural blockade by tetrodotoxin prevented mast cell protease II release in response to antidromic electrical stimulation of mesenteric afferents. The results support a hypothesis that afferent innervation of enteric mast cells releases histamine and mast cell protease II, both of which are known to act in a diffuse paracrine manner to influence the behavior of enteric nervous system neurons and to elevate the sensitivity of spinal afferent terminals.

Contractile Response to Electrical Stimulation of the Small Intestine in Anesthetized and Awake Dogs

2008 ◽  
Vol 13 (6) ◽  
pp. 553-557 ◽  
Author(s):  
Anton Moritz ◽  
Sharon Grundfest-Broniatowski ◽  
Laszlo Ilyes ◽  
Jerry Kasick ◽  
Gordon Jacobs ◽  
...  
Keyword(s):  
Small Intestine ◽  
Electrical Stimulation ◽  
Contractile Response ◽  
Stimulation Of
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