Effect of deglycyrrhizinized liquorice on gastric acid secretion, histidine decarboxylase activity and serum gastrin level in the rat

1973 ◽  
Vol 29 (5) ◽  
pp. 570-571 ◽  
Author(s):  
R. Håkanson ◽  
G. Liedberg ◽  
J. Oscarson ◽  
J. F. Rehfeld ◽  
F. Stadil
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Histidine Decarboxylase ◽  
Serum Gastrin ◽  
Gastrin Level ◽  
Serum Gastrin Level ◽  
Decarboxylase Activity ◽  
Histidine Decarboxylase Activity

Eleveted serum gastrin level cannot maintain basal and stimulated gastric acid secretion in histamine deficient transgenic mice

2001 ◽  
Vol 120 (5) ◽  
pp. A180
Author(s):  
Béla Hunyady ◽  
Annamária Zólyomi ◽  
József Czimmer ◽  
Gyula Mózsik ◽  
Edit Buzás ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Serum Gastrin ◽  
Gastrin Level ◽  
Serum Gastrin Level

Effects of E, F, and I series prostaglandins and analogues on growth of gastroduodenal mucosa and pancreas

1985 ◽  
Vol 248 (2) ◽  
pp. G170-G175 ◽  
Author(s):  
A. Dembinski ◽  
S. J. Konturek
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Serum Gastrin ◽  
Gastrin Level ◽  
Term Treatment ◽  
Dna And Rna ◽  
Gastroduodenal Mucosa ◽  
Long Term Treatment ◽  
Term Administration

We investigated the effects of prostaglandins (PG) of E, F, and I series and their stable analogues on gastric acid secretion, serum gastrin level, and growth of gastroduodenal mucosa and pancreas in rats. Short-term administration (every 8 h for 48 h) of E and F series PGs and their stable analogues caused significant stimulation of DNA synthesis; prolonged PG treatment (every 8 h for 10 days) significantly increased weight and total DNA and RNA contents of the organs tested. PGs of E series were given in doses that inhibited gastric acid secretion about 50% and raised serum gastrin significantly; PGs of F series were injected in the same dose (1,000 micrograms/kg) as PGs of E series but did not affect acid secretion or serum gastrin. Short- or long-term treatment with PGI2 or its stable analogue (Hoe 892), injected in doses causing about 50% inhibition of acid secretion and significant increments in serum gastrin levels, failed to affect any of the growth-related parameters in the stomach, duodenum, or pancreas. We conclude that PGs of E and F (but not of I) series exhibit a marked stimulatory influence on growth of gastroduodenal mucosa and pancreas. These trophic effects appear to be unrelated to gastric secretion or serum gastrin release.

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