Intracellular enzymes in renal lymph as a measure of anoxic injury of the kidney

G. Szabó; Z. Magyar

doi:10.1007/bf01926647

Intracellular enzymes of collagen biosynthesis in rat kidney in streptozotocin diabetes

Diabetes ◽

10.2337/diabetes.25.11.1066 ◽

1976 ◽

Vol 25 (11) ◽

pp. 1066-1070 ◽

Cited By ~ 25

Author(s):

J. Risteli ◽

V. A. Koivisto ◽

H. K. Akerblom ◽

K. I. Kivirikko

Keyword(s):

Rat Kidney ◽

Streptozotocin Diabetes ◽

Collagen Biosynthesis ◽

Intracellular Enzymes

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Mechanisms of action of chloroalanyl antibacterial peptides. Identification of the intracellular enzymes inactivated on treatment of Escherichia coli JSR-O with the dipeptide beta Cl-LAla-beta Cl-LAla.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)57484-1 ◽

1986 ◽

Vol 261 (17) ◽

pp. 7871-7878

Author(s):

W Boisvert ◽

K S Cheung ◽

S A Lerner ◽

M Johnston

Keyword(s):

Escherichia Coli ◽

Mechanisms Of Action ◽

Antibacterial Peptides ◽

Intracellular Enzymes

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Kir6.2-containing ATP-sensitive potassium channels protect cortical neurons from ischemic/anoxic injury in vitro and in vivo

Neuroscience ◽

10.1016/j.neuroscience.2006.10.043 ◽

2007 ◽

Vol 144 (4) ◽

pp. 1509-1515 ◽

Cited By ~ 31

Author(s):

H.-S. Sun ◽

Z.-P. Feng ◽

P.A. Barber ◽

A.M. Buchan ◽

R.J. French

Keyword(s):

Potassium Channels ◽

Cortical Neurons ◽

Anoxic Injury

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Difficulties in assessing brain death in a case of benzodiazepine poisoning with persistent cerebral blood flow

Human & Experimental Toxicology ◽

10.1191/0960327104ht478cr ◽

2004 ◽

Vol 23 (10) ◽

pp. 503-505 ◽

Cited By ~ 15

Author(s):

Frédéric Marrache ◽

Bruno Megarbane ◽

Stéphane Pirnay ◽

Abdel Rhaoui ◽

Marie Thuong

Keyword(s):

Blood Flow ◽

Cardiac Arrest ◽

Cerebral Blood Flow ◽

Brain Death ◽

Intracranial Hypertension ◽

Multiorgan Failure ◽

Deep Coma ◽

Ventricular Drainage ◽

Eeg Activity ◽

Anoxic Injury

Assessing brain death may sometimes be difficult, with isoelectric EEG following psychotrope overdoses or normal cerebral blood flow (CBF) persisting despite brain death in the case of ventricular drainage or craniotomy. A 42-year-old man, resuscitated after cardiac arrest following a suicidal ingestion of ethanol, bromazepam and zopiclone, was admitted in deep coma. On day 4, his brainstem reflexes and EEG activity disappeared. On day 5, his serum bromazepam concentration was 817 ng/ml (therapeutic: 80-150). The patient was unresponsive to 1 mg of flumazenil. MRI showed diffuse cerebral swelling. CBF assessed by angiography and Doppler remained normal and EEG isoelectric until he died on day 8 with multiorgan failure. There was a discrepancy between the clinically and EEG-assessed brain death, and CBF persistence. We hypothesized that brain death, resulting from diffuse anoxic injury, may lead, in the absence of major intracranial hypertension, to angiographic misdiagnoses. Therefore, EEG remains useful to assess diagnosis in such unusual cases.

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Factors affecting the activation and inhibition of intracellular enzymes for degradation of 1,2 diamino benzene: kinetics and thermodynamic studies

Bioprocess and Biosystems Engineering ◽

10.1007/s00449-015-1460-1 ◽

2015 ◽

Vol 38 (11) ◽

pp. 2221-2230 ◽

Cited By ~ 1

Author(s):

Saranya P ◽

Sekaran G

Keyword(s):

Thermodynamic Studies ◽

Factors Affecting ◽

Intracellular Enzymes ◽

Kinetics And Thermodynamic

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Intracellular serine proteinase of Bacillus subtilis strain Marburg 168. Comparison with the homologous enzyme from Bacillus subtilis strain A-50

Biochemical Journal ◽

10.1042/bj1790333 ◽

1979 ◽

Vol 179 (2) ◽

pp. 333-339 ◽

Cited By ~ 13

Author(s):

A Y Strongin ◽

D I Gorodetsky ◽

I A Kuznetsova ◽

V V Yanonis ◽

Z T Abramov ◽

...

Keyword(s):

Bacillus Subtilis ◽

Serine Proteinase ◽

Subtilis Strain ◽

Bacterial Strains ◽

Terminal Sequence ◽

Gramicidin S ◽

Intracellular Enzymes ◽

Sepharose 4B ◽

Homologous Enzyme ◽

Strict Selection

Intracellular serine proteinase was isolated from sporulating cells of Bacillus subtilis Marburg 168 by gramicidin S-Sepharose 4B affinity chromatography. The enzymological characteristics, the amino acid composition and the 19 residues of the N-terminal sequence of the enzyme are reported. The isolated proteinase was closely related to, but not completely identical with, the intracellular serine proteinase of B. subtilis A-50. The divergence between these two intracellular enzymes was less than that between the corresponding extracellular serine proteinases (subtilisins) of types Carlsberg and BPN′!, produced by these bacterial strains. This may be connected with the more strict selection constraints imposed in intracellular enzymes during evolution.

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Postanoxic Burst Suppression Electroencephalogram in a Comatose Child Associated with Spontaneous Eyelid Opening

Case Reports in Critical Care ◽

10.1155/2012/760407 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3

Author(s):

John R. Crawford

Keyword(s):

Intensive Care ◽

Poor Prognosis ◽

Burst Suppression ◽

Pathophysiological Mechanism ◽

Rare Phenomenon ◽

Anoxic Injury ◽

Eye Opening ◽

Insight Into

Spontaneous eye opening associated with burst suppression electroencephalogram has been reported in adults following postanoxic injury. Previous reports have correlated the onset of epileptiform bursts with the eye opening and attribute it to a brainstem-release phenomenon associated with poor prognosis. The author presents a case of a 12-year-old boy with burst suppression electroencephalogram following severe anoxic injury where the eye opening occurred at the conclusion of the bursts that has never been previously reported. These electroencephalographic findings are important for intensive care physicians to recognize and may provide further insight into the pathophysiological mechanism of this rare phenomenon.

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