Early-life undernutrition causes deficits in rat dentate gyrus granule cell number

1991 ◽  
Vol 47 (10) ◽  
pp. 1073-1074 ◽  
Author(s):  
K. S. Bedi
Keyword(s):  
Dentate Gyrus ◽  
Granule Cell ◽  
Early Life ◽  
Cell Number

Effects of formaldehyde exposure on granule cell number and volume of dentate gyrus: A histopathological and stereological study

2006 ◽  
Vol 1122 (1) ◽  
pp. 191-200 ◽  
Author(s):  
Huseyin Aslan ◽  
Ahmet Songur ◽  
Ayten Turkkanı Tunc ◽  
Oguz Aslan Ozen ◽  
Orhan Bas ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Granule Cell ◽  
Cell Number ◽  
Formaldehyde Exposure

Increased cell proliferation and granule cell number in the dentate gyrus of protein repair-deficient mice

2005 ◽  
Vol 493 (4) ◽  
pp. 524-537 ◽  
Author(s):  
Christine E. Farrar ◽  
Christine S. Huang ◽  
Steven G. Clarke ◽  
Carolyn R. Houser
Keyword(s):  
Cell Proliferation ◽  
Dentate Gyrus ◽  
Granule Cell ◽  
Cell Number ◽  
Protein Repair ◽  
Deficient Mice

scholarly journals Stress and Corticosteroids Aggravate Morphological Changes in the Dentate Gyrus after Early-Life Experimental Febrile Seizures in Mice

2018 ◽  
Vol 9 ◽  
Author(s):  
Jolien S. van Campen ◽  
Ellen V. S. Hessel ◽  
Kirsten Bohmbach ◽  
Giorgio Rizzi ◽  
Paul J. Lucassen ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Early Life ◽  
Morphological Changes ◽  
Febrile Seizures

scholarly journals LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance

Neuron ◽  
2017 ◽  
Vol 95 (4) ◽  
pp. 928-943.e3 ◽  
Author(s):  
Yuki Hashimotodani ◽  
Kaoutsar Nasrallah ◽  
Kyle R. Jensen ◽  
Andrés E. Chávez ◽  
Daniel Carrera ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Granule Cell ◽  
Dentate Granule Cell ◽  
Mossy Cell

Spontaneous Waves in the Dentate Gyrus of Slices From the Ventral Hippocampus

2004 ◽  
Vol 92 (6) ◽  
pp. 3385-3398 ◽  
Author(s):  
Laura Lee Colgin ◽  
Don Kubota ◽  
Fernando A. Brucher ◽  
Yousheng Jia ◽  
Erin Branyan ◽  
...  
Keyword(s):  
Gap Junctions ◽  
Dentate Gyrus ◽  
Granule Cell ◽  
Action Potentials ◽  
Slow Wave Sleep ◽  
Glutamate Release ◽  
Acetylcholinesterase Inhibitor ◽  
Granule Cell Layer ◽  
Perforant Path ◽  
The Waves

Spontaneous negative-going potentials occurring at an average frequency of 0.7 Hz were recorded from the dentate gyrus of slices prepared from the temporal hippocampus of young adult rats. These events (here termed “dentate waves”) in several respects resembled the dentate spikes described for freely moving rats during immobile behaviors and slow-wave sleep. Action potentials were observed on the descending portion of the in vitro waves and, as expected from this, whole cell recordings established that the waves were composed of depolarizing currents. Dentate waves appeared to be locally generated within the granule cell layer and were greatly reduced by antagonists of AMPA-type glutamate receptors or by lesions to the entorhinal cortex. Simultaneous recordings indicated that the waves were often synchronized in the inner and outer blades of the dentate gyrus. Knife cuts through the perforant path and the commissural/associational system did not eliminate synchronization, leaving electrotonic propagation via gap junctions as its probable cause. In accord with this, cuts that separated the two blades of the dentate eliminated synchronization between them, and a compound that inhibits gap junctions reduced wave activity. Dentate waves were regularly accompanied by sharp waves in field CA3 and were reduced in size by the acetylcholinesterase inhibitor, physostigmine. It is hypothesized that dentate waves occur when spontaneous glutamate release from dentate afferents produces action potentials in neighboring granule cells that then summate electrotonically into a population event; once initiated, the waves propagate, again electrotonically, and thereby engage a significant portion of the granule cell population.

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