5-hydroxytryptamine induced changes in body temperature of newborn kittens and guinea-pigs and the effect of indomethacin thereon

1978 ◽  
Vol 34 (1) ◽  
pp. 58-59 ◽  
Author(s):  
M. Székely
Keyword(s):  
Body Temperature ◽  
Guinea Pigs ◽  
Induced Changes

Hypoxia-induced changes in shivering and body temperature

1987 ◽  
Vol 62 (6) ◽  
pp. 2477-2484 ◽  
Author(s):  
H. Gautier ◽  
M. Bonora ◽  
S. A. Schultz ◽  
J. E. Remmers
Keyword(s):  
Central Nervous System ◽  
Body Temperature ◽  
Room Temperature ◽  
Co2 Concentration ◽  
Hypoxic Conditions ◽  
O2 Concentration ◽  
The Central Nervous System ◽  
Induced Changes ◽  
Maintain Body Temperature ◽  
Ambient Hypoxia

Experiments were carried out on conscious cats to evaluate the general characteristics and modes of action of hypoxia on thermoregulation during cold stress. Intact and carotid-denervated (CD) conscious cats were exposed to ambient hypoxia (low inspired O2 fraction) or CO hypoxia in prevailing laboratory (23–25 degrees C) or cold (5–8 degrees C) environments. In the cold, both groups promptly decreased shivering and body temperature when exposed to either type of hypoxia. Small increases in CO2 concentration reinstituted shivering in both groups. At the same inspired concentration of O2, CD animals decreased shivering and body temperature more than intact cats. While this difference resulted, in part, from a lower alveolar PO2 in CD cats, a difference between intact and CD cats was apparent when the two groups were compared at the same alveolar PO2. During more prolonged hypoxia (45 min), shivering returned but did not reach normoxic levels, and body temperature tended to stabilize at a hypothermic value. Exposure to various levels of hypoxia produced graded suppression of shivering, with the result that the change in body temperature varied directly with inspired O2 concentration. Hypoxia appears to act on the central nervous system to suppress shivering and sinus nerve afferents appear to counteract this direct effect of hypoxia. In intact cats, this counteraction appears to be sufficient to maintain body temperature under hypoxic conditions at room temperature but not in the cold.

Effect of Restraint on Body Temperature in Guinea Pigs

1958 ◽  
Vol 12 (2) ◽  
pp. 214-216 ◽  
Author(s):  
Charles G. Wilber ◽  
Paul F. Robinson
Keyword(s):  
Body Temperature ◽  
Guinea Pigs

scholarly journals Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers

2020 ◽  
Vol 9 (7) ◽  
pp. 2108
Author(s):  
Paulo Ávila-Gómez ◽  
Pablo Hervella ◽  
Andrés Da Silva-Candal ◽  
María Pérez-Mato ◽  
Manuel Rodríguez-Yáñez ◽  
...  
Keyword(s):  
Body Temperature ◽  
Clot Lysis ◽  
Necrosis Factor Alpha ◽  
Poor Outcome ◽  
Tnf Α ◽  
Influence Of Temperature On ◽  
Factor Alpha ◽  
Higher Temperature ◽  
Poor Outcomes ◽  
Induced Changes

Although hyperthermia is associated with poor outcomes in ischaemic stroke (IS), some studies indicate that high body temperature may benefit reperfusion therapies. We assessed the association of temperature with effective reperfusion (defined as a reduction of ≥8 points in the National Institute of Health Stroke Scale (NIHSS) within the first 24 h) and poor outcome (modified Rankin Scale (mRS) > 2) in 875 retrospectively-included IS patients. We also studied the influence of temperature on thrombolytic (cellular fibronectin (cFn); matrix metalloproteinase 9 (MMP-9)) and inflammatory biomarkers (tumour necrosis factor-alpha (TNF-α), interleukin 6 (IL-6)) and their relationship with effective reperfusion. Our results showed that a higher temperature at 24 but not 6 h after stroke was associated with failed reperfusion (OR: 0.373, p = 0.001), poor outcome (OR: 2.190, p = 0.005) and higher IL-6 levels (OR: 0.958, p < 0.0001). Temperature at 6 h was associated with higher MMP-9 levels (R = 0.697; p < 0.0001) and effective reperfusion, although this last association disappeared after adjusting for confounding factors (OR: 1.178, p = 0.166). Our results suggest that body temperature > 37.5 °C at 24 h, but not at 6 h after stroke, is correlated with reperfusion failure, poor clinical outcome, and infarct size. Mild hyperthermia (36.5–37.5 °C) in the first 6 h window might benefit drug reperfusion therapies by promoting clot lysis.

scholarly journals Effect of chronic hypercapnia on body temperature regulation

1975 ◽  
Vol 38 (5) ◽  
pp. 900-906 ◽  
Author(s):  
K. E. Schaefer ◽  
A. A. Messier ◽  
C. Morgan ◽  
G. T. Baker
Keyword(s):  
Body Temperature ◽  
Guinea Pigs ◽  
Time Course ◽  
Prolonged Exposure ◽  
Respiratory Acidosis ◽  
Serotonin Content ◽  
Regulatory Processes ◽  
Transient Rise ◽  
Acid Base Status ◽  
Partial Compensation

Guinea pigs and rats exposed to 15% CO2 for 7 days showed a parallel time course of changes in pH, body temperature (TB), and oxygen consumption (VO2). Between 1 and 6 h of exposure the maximal drop in actual pH occurred in guinea pigs simultaneously with the maximal fall in TB and VO2. During the subsequent period pH TB, VO2 rose again. Skin blood content (heat loss) also exhibited a biphasic pH-dependent time course. Animals showing no partial compensation of respiratory acidosis during 3 days exposure also failed in raising their TB back to normal in this time. The behavior of TB was found to be a good indicator of the acid-base status and adaptive potential of the animals to hypercapnia. Similar results were obtained in rats. Thermo-regulatory processes in the hypothalamus were affected during exposure to 15% CO2. Both guinea pigs and rats showed a decrease in norepinephrine content of the hypothalamus during the first part of exposure reaching a maximal fall at the end of 24 h. The serotonin content increased slightly during this period. During prolonged exposure to 3% CO2 for 7 days, TB showed a transient rise, and VO2 was slightly elevated.

Ambient temperature modulates hypoxic-induced changes in rat body temperature and activity differentially

2001 ◽  
Vol 280 (4) ◽  
pp. R1190-R1196 ◽  
Author(s):  
B. Bishop ◽  
G. Silva ◽  
J. Krasney ◽  
H. Nakano ◽  
A. Roberts ◽  
...  
Keyword(s):  
Body Temperature ◽  
Ambient Temperature ◽  
Induced Responses ◽  
Brain Pathology ◽  
Level Of Activity ◽  
Time Courses ◽  
Induced Changes ◽  
Subsequent Rise ◽  
The Brain

When rats, acclimated to an ambient temperature (Ta) of 29°C, are exposed to 10% O2 for 63 h, the circadian rhythms of body temperature (Tb) and level of activity (La) are abolished, Tb falls to a hypothermic nadir followed by a climb to a hyperthermic peak, Laremains depressed (Bishop B, Silva G, Krasney J, Salloum A, Roberts A, Nakano H, Shucard D, Rifkin D, and Farkas G. Am J Physiol Regulatory Integrative Comp Physiol 279: R1378–R1389, 2000), and overt brain pathology is detected (Krasney JA, Farkas G, Shucard DW, Salloum AC, Silva G, Roberts A, Rifkin D, Bishop B, and Rubio A. Soc Neurosci Abstr 25: 581, 1999). To determine the role of Ta in these hypoxic-induced responses, Tb and La data were detected by telemetry every 15 min for 48 h on air, followed by 63 h on 10% O2 from rats acclimated to 25 or 21°C. Magnitudes and rates of decline in Tb after onset of hypoxia were inversely proportional to Ta, whereas magnitudes and rates of Tb climb after the hypothermic nadir were directly proportional to Ta. No hyperthermia, so prominent at 29°C, occurred at 25 or 21°C. The hypoxic depression of La was least at 21°C and persisted throughout the hypoxia. In contrast, Ta was a strong determinant of the magnitudes and time courses of the initial fall and subsequent rise in Tb. We propose that the absence of hyperthermia at 21 and 25°C as well as a persisting hypothermia may protect the brain from overt pathology.

Pavlovian conditioning of drug-induced changes in body temperature

1983 ◽  
Vol 23 (3) ◽  
pp. 365-391 ◽  
Author(s):  
Christopher L. Cunningham ◽  
John C. Crabbe ◽  
Henk Rigter
Keyword(s):  
Body Temperature ◽  
Pavlovian Conditioning ◽  
Drug Induced ◽  
Induced Changes

Role of catecholamines in thyroxine-induced changes in metabolism and body temperature during exercise in dogs

1976 ◽  
Vol 32 (1) ◽  
pp. 68-69 ◽  
Author(s):  
Hanna Kaciuba-Uściłko ◽  
Zofia Brzezińska ◽  
J. E. Greenleaf
Keyword(s):  
Body Temperature ◽  
Induced Changes
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