Are there any nonspecific large molecule-large molecule interactions?

1974 ◽  
Vol 30 (12) ◽  
pp. 1473-1474 ◽  
Author(s):  
William C. Boyd
Keyword(s):  
Large Molecule ◽  
Molecule Interactions

Small Molecule Interactions with Protein−Tyrosine Phosphatase PTP1B and Their Use in Inhibitor Design†

Biochemistry ◽  
1996 ◽  
Vol 35 (50) ◽  
pp. 15989-15996 ◽  
Author(s):  
Terrence R. Burke, ◽  
Bin Ye ◽  
Xinjian Yan ◽  
Shaomeng Wang ◽  
Zongchao Jia ◽  
...  
Keyword(s):  
Small Molecule ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Inhibitor Design ◽  
Protein Tyrosine ◽  
Molecule Interactions

scholarly journals P2X7 Receptors and TMEM16 Channels Are Functionally Coupled with Implications for Macropore Formation and Current Facilitation

2021 ◽  
Vol 22 (12) ◽  
pp. 6542
Author(s):  
Kate Dunning ◽  
Adeline Martz ◽  
Francisco Andrés Peralta ◽  
Federico Cevoli ◽  
Eric Boué-Grabot ◽  
...  
Keyword(s):  
Single Channel ◽  
Cell Membrane Permeability ◽  
Large Molecule ◽  
Cholesterol Depletion ◽  
Open Probability ◽  
P2x7 Receptors ◽  
Biochemical Assays ◽  
Functional Complex ◽  
Macropore Formation ◽  
Current Facilitation

P2X7 receptors (P2X7) are cationic channels involved in many diseases. Following their activation by extracellular ATP, distinct signaling pathways are triggered, which lead to various physiological responses such as the secretion of pro-inflammatory cytokines or the modulation of cell death. P2X7 also exhibit unique behaviors, such as “macropore” formation, which corresponds to enhanced large molecule cell membrane permeability and current facilitation, which is caused by prolonged activation. These two phenomena have often been confounded but, thus far, no clear mechanisms have been resolved. Here, by combining different approaches including whole-cell and single-channel recordings, pharmacological and biochemical assays, CRISPR/Cas9 technology and cell imaging, we provide evidence that current facilitation and macropore formation involve functional complexes comprised of P2X7 and TMEM16, a family of Ca2+-activated ion channel/scramblases. We found that current facilitation results in an increase of functional complex-embedded P2X7 open probability, a result that is recapitulated by plasma membrane cholesterol depletion. We further show that macropore formation entails two distinct large molecule permeation components, one of which requires functional complexes featuring TMEM16F subtype, the other likely being direct permeation through the P2X7 pore itself. Such functional complexes can be considered to represent a regulatory hub that may orchestrate distinct P2X7 functionalities.

Amorphous Co(OH)2 nanocages achieving efficient photo-induced charge transfer for significant SERS activity

2022 ◽  
Author(s):  
Jian Yu ◽  
CHEN CHAO ◽  
Jie Lin ◽  
Xiangyu Meng ◽  
Lin Qiu ◽  
...  
Keyword(s):  
Charge Transfer ◽  
Raman Scattering ◽  
Vibronic Coupling ◽  
Substrate Molecule ◽  
Surface Enhanced ◽  
Critical Issues ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Induced Charge ◽  
Molecule Interactions

Boosting substrate-molecule interactions, especially the strong vibronic coupling and efficient photo-induced charge transfer (PICT) transitions, are critical issues to improve surface-enhanced Raman scattering (SERS) sensitivity of non-metal substrates. Here, by...

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