Human skin model capable of natural shape variation

1988 ◽  
Vol 3 (5) ◽  
pp. 265-271 ◽  
Author(s):  
Koji Komatsu
Keyword(s):  
Human Skin ◽  
Shape Variation ◽  
Skin Model

scholarly journals Disinfectant effectiveness against SARS-CoV-2 and influenza viruses present on human skin: model-based evaluation

2021 ◽  
Author(s):  
Ryohei Hirose ◽  
Risa Bandou ◽  
Hiroshi Ikegaya ◽  
Naoto Watanabe ◽  
Takuma Yoshida ◽  
...  
Keyword(s):  
Human Skin ◽  
Influenza Viruses ◽  
Skin Model ◽  
Model Based

Basic Red 51, a permitted semi-permanent hair dye, is cytotoxic to human skin cells: Studies in monolayer and 3D skin model using human keratinocytes (HaCaT)

2014 ◽  
Vol 227 (2) ◽  
pp. 139-149 ◽  
Author(s):  
Thalita B. Zanoni ◽  
Manoela Tiago ◽  
Fernanda Faião-Flores ◽  
Silvia B. de Moraes Barros ◽  
Aalt Bast ◽  
...  
Keyword(s):  
Human Skin ◽  
Human Keratinocytes ◽  
Skin Model ◽  
Hair Dye ◽  
Skin Cells ◽  
Human Skin Cells ◽  
3D Skin

scholarly journals Development and Evaluation of a Topical Anti-Inflammatory Preparation Containing Dodonaea polyandra Extract

2015 ◽  
Vol 18 (4) ◽  
pp. 578 ◽  
Author(s):  
Bradley S Simpson ◽  
Xianling Luo ◽  
Jiping Wang ◽  
Yunmei Song ◽  
David Claudie ◽  
...  
Keyword(s):  
Phase Separation ◽  
Human Skin ◽  
Dosage Form ◽  
Interleukin 1 ◽  
In Vitro Release ◽  
Skin Inflammation ◽  
Skin Model ◽  
Inflammation Model ◽  
Anti Inflammatory

Purpose: We have previously reported that the Australian Northern Kaanju (Kuuku I’yu) medicinal plant Dodonaea polyandra has anti-inflammatory activity. This is attributed largely to the presence of clerodane diterpenoids contained within the leaf resin. We envisaged developing a topical preparation to treat indications relating to skin inflammation. However, it was unknown whether the resin could be incorporated into a suitable dosage form while retaining the therapeutic value demonstrated in previous work. Therefore, the following study was undertaken to assess parameters of safety and efficacy for a prototype formulation containing the leaf resin extracted from D. polyandra. Methods: Using the assessment criteria of optimum appearance, tactile feeling, spreadability and odour, 78 different formulations were developed. Formulation stability was assessed using a centrifugal test with preparations displaying phase separation further modified or re-formulated. A prototype formulation containing 5% w/w plant resin was selected and subjected to in vitro release studies. This was quantified through HPLC analysis using two major bioactive diterpenoids as reference. The prototype formulation was tested for efficacy in a TPA-induced acute murine skin inflammation model as well as a 3D human skin model for irritancy/toxicity (Epiderm™). Results: The prototype resin cream was a chartreuse-coloured homogenous semisolid preparation that was readily spreadable upon contact with skin with no sensation of tackiness, residual greasiness, or irritation. The optimized cream showed no phase separation after 30 min centrifugation at 825 g. In the TPA-induced inflammation model, the resin formulation significantly reduced ear thickness and interleukin-1 beta levels in mouse ear tissue. The 5% w/w resin cream formulation showed no irritancy in a 3D human skin model. Conclusions: Our results demonstrate that bioactive resin from D. polyandra can be formulated into a stable and non-irritant semi-solid dosage form and reduce parameters of acute skin inflammation in vivo. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

Molecular characterization of reconstructed skin model by Raman microspectroscopy: Comparison with excised human skin

Biopolymers ◽  
2007 ◽  
Vol 87 (4) ◽  
pp. 261-274 ◽  
Author(s):  
Ali Tfayli ◽  
Olivier Piot ◽  
Florence Draux ◽  
Franck Pitre ◽  
Michel Manfait
Keyword(s):  
Molecular Characterization ◽  
Human Skin ◽  
Raman Microspectroscopy ◽  
Skin Model ◽  
Reconstructed Skin

Recapitulation of Native Dermal Tissue in a Full-Thickness Human Skin Model Using Human Collagens

2018 ◽  
Vol 24 (11-12) ◽  
pp. 873-881 ◽  
Author(s):  
Arnout Mieremet ◽  
Marion Rietveld ◽  
Rianne van Dijk ◽  
Joke A. Bouwstra ◽  
Abdoelwaheb El Ghalbzouri
Keyword(s):  
Human Skin ◽  
Full Thickness ◽  
Skin Model ◽  
Dermal Tissue

Development of a reconstructed human skin model for angiogenesis

2003 ◽  
Vol 11 (4) ◽  
pp. 275-284 ◽  
Author(s):  
Parbinder S. Sahota ◽  
J. Lance Burn ◽  
Martin Heaton ◽  
Eric Freedlander ◽  
Simon K. Suvarna ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Model ◽  
Reconstructed Human Skin

scholarly journals 433 An innervated, vascularized and immunocompetent human skin model to evaluate the properties of chemical substances

2019 ◽  
Vol 139 (9) ◽  
pp. S288
Author(s):  
Q. Muller ◽  
M. Beaudet ◽  
S. Bellenfant ◽  
R. Pépin ◽  
A. Brulefert ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Model ◽  
Chemical Substances

scholarly journals Construction of Three-dimensional Human Skin Model Involving Dendritic Cells and Its Application to Skin Sensitization Test

2008 ◽  
Vol 128 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Tadashi UCHINO ◽  
Toshiaki TAKEZAWA ◽  
Yoshiaki IKARASHI ◽  
Hiroshi TOKUNAGA
Keyword(s):  
Dendritic Cells ◽  
Human Skin ◽  
Three Dimensional ◽  
Skin Sensitization ◽  
Skin Model

Immune Cell-Supplemented Human Skin Model for Studying Fungal Infections

2016 ◽  
pp. 439-449 ◽  
Author(s):  
Andreas Kühbacher ◽  
Kai Sohn ◽  
Anke Burger-Kentischer ◽  
Steffen Rupp
Keyword(s):  
Human Skin ◽  
Immune Cell ◽  
Fungal Infections ◽  
Skin Model
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