Effect ofBordetella pertussis vaccine on plasma corticosterone level and on ACTH-induced corticosterone secretion in rats

1973 ◽  
Vol 29 (1) ◽  
pp. 112-113 ◽  
Author(s):  
B. Csaba ◽  
L. Muszbek
Keyword(s):  
Pertussis Vaccine ◽  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Plasma Corticosterone Level ◽  
Corticosterone Secretion ◽  
Ofbordetella Pertussis

PITUITARY AND ADRENAL RESPONSIVENESS IN RATS AFTER PROLONGED TREATMENT WITH ACTH

1963 ◽  
Vol 41 (1) ◽  
pp. 1771-1777
Author(s):  
E. Stark ◽  
J. Fachet ◽  
Katherine Mihály
Keyword(s):  
Prolonged Exposure ◽  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Prolonged Treatment ◽  
Plasma Corticosterone Level ◽  
Operative Trauma ◽  
Corticosterone Secretion ◽  
Adrenal Corticosterone

Prolonged exposure to ACTH considerably increased adrenal responsiveness in the rat both in vivo and in vitro. The last of 5 and 14 daily injections each produced a significantly higher blood corticosterone level than did a single injection. In the presence of ACTH added in vitro, adrenal corticosterone production in animals subjected to prolonged treatment with ACTH significantly exceeded the production per unit of weight and unit of time measured in saline-treated animals. Reduced adrenal responsiveness in the stage of resistance, elicited by formalin as a non-specific stress, cannot be invoked as an explanation for the absence of an increase in corticosterone secretion. The conclusion is that after prolonged exposure to non-specific stress there is no longer any ACTH hypersecretion.Twenty-four hours after the last injection of prolonged ACTH treatment there was inhibition of endogenous ACTH release by the pituitary gland, formalin produced no rise in the corticosterone level of the peripheral blood, and operative trauma caused substantially less ascorbic acid depletion than it did in saline-treated controls, although the plasma corticosterone level was normal or below normal.

PITUITARY AND ADRENAL RESPONSIVENESS IN RATS AFTER PROLONGED TREATMENT WITH ACTH

1963 ◽  
Vol 41 (8) ◽  
pp. 1771-1777 ◽  
Author(s):  
E. Stark ◽  
J. Fachet ◽  
Katherine Mihály
Keyword(s):  
Prolonged Exposure ◽  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Prolonged Treatment ◽  
Plasma Corticosterone Level ◽  
Operative Trauma ◽  
Corticosterone Secretion ◽  
Adrenal Corticosterone

Prolonged exposure to ACTH considerably increased adrenal responsiveness in the rat both in vivo and in vitro. The last of 5 and 14 daily injections each produced a significantly higher blood corticosterone level than did a single injection. In the presence of ACTH added in vitro, adrenal corticosterone production in animals subjected to prolonged treatment with ACTH significantly exceeded the production per unit of weight and unit of time measured in saline-treated animals. Reduced adrenal responsiveness in the stage of resistance, elicited by formalin as a non-specific stress, cannot be invoked as an explanation for the absence of an increase in corticosterone secretion. The conclusion is that after prolonged exposure to non-specific stress there is no longer any ACTH hypersecretion.Twenty-four hours after the last injection of prolonged ACTH treatment there was inhibition of endogenous ACTH release by the pituitary gland, formalin produced no rise in the corticosterone level of the peripheral blood, and operative trauma caused substantially less ascorbic acid depletion than it did in saline-treated controls, although the plasma corticosterone level was normal or below normal.

Bacopa monnieri alleviates aluminium chloride-induced anxiety by regulating plasma corticosterone level in Wistar rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Senthil Murugan Murugaiyan ◽  
Rajesh Bhargavan
Keyword(s):  
Oral Administration ◽  
Corticosterone Level ◽  
Tween 80 ◽  
Treated Group ◽  
Plasma Corticosterone ◽  
Bacopa Monnieri ◽  
Aluminium Chloride ◽  
Control Group ◽  
Plasma Corticosterone Level ◽  
Protective Groups

AbstractObjectivesAluminium is present in food preparations, antacids and many medications. It causes neurodegeneration thereby resulting in a spectrum of neurological disorders such as dementia, Alzheimer’s disease and anxiety. Bacopa monnieri (BM) is widely used in ayurvedic medicine to improve memory functions. Its anxiolytic property was investigated in this study by using elevated plus maze (EPM) and plasma corticosterone level.MethodsThirty rats were assigned into five groups. Control group received distilled water, and 0.5% tween 80, AlCl3 group received Aluminium Chloride (AlCl3), Protective groups (BM100 + AlCl3 group and BM200 + AlCl3 group) received AlCl3 and BM at two different doses, and the BM200 group received BM. The EPM experiment was performed at the end of the 4th week of oral administration of BM and AlCl3 followed by the measurement of plasma corticosterone.ResultsOral administration of AlCl3 to rats increases the levels of anxiety as seen in a decrease in the percentage of entries into the open arms of EPM, an increase in grooming frequency and defecation index. However, the rats in the protective groups shown an increase in the percentage of open arm entries and rearing frequency, and decreased grooming frequency and defecation index. AlCl3 alone treated group showed a significant increase in the plasma corticosterone levels compared to the control group. Whereas the protective groups have shown a significant decrease in the plasma corticosterone levels than the AlCl3 alone treated group.ConclusionsHence the BM has potential role in reverting the anxiogenic effect of AlCl3 in the amygdala as it is evident from the plasma corticosterone levels and the EPM parameters of different groups under study.

scholarly journals Inflammatory Pain and Corticosterone Response in Infant Rats: Effect of 5-HT1A Agonist Buspirone Prior to Gestational Stress

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Irina P. Butkevich ◽  
Viktor A. Mikhailenko ◽  
Tat'yana R. Bagaeva ◽  
Elena A. Vershinina ◽  
Anna Maria Aloisi ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Inflammatory Pain ◽  
Formalin Test ◽  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Male Rats ◽  
Plasma Corticosterone Level ◽  
Infant Rats ◽  
Corticosterone Response ◽  
Gestational Stress

Our researches have shown that gestational stress causes exacerbation of inflammatory pain in the offspring; the maternal 5-HT1A agonist buspirone before the stress prevents the adverse effect. The serotonergic system and hypothalamo-pituitary-adrenal (HPA) axis are closely interrelated. However, interrelations between inflammatory pain and the HPA axis during the hyporeactive period of the latter have not been studied. The present research demonstrates that formalin-induced pain causes a gradual and prolonged increase in plasma corticosterone level in 7-day-old male rats; twenty-four hours after injection of formalin, the basal corticosterone level still exceeds the initial basal corticosterone value. Chronic treatments of rat dams with buspirone before restraint stress during gestation normalize in the offspring pain-like behavior and induce during the acute phase in the formalin test the stronger corticosterone increase as compared to the stress hormonal elevation in animals with other prenatal treatments. Negative correlation between plasma corticosterone level and the number of flexes+shakes is revealed in buspirone+stress rats. The new data enhance the idea about relativity of the HPA axis hyporeactive period and suggest that maternal buspirone prior to stress during gestation may enhance an adaptive mechanism of the inflammatory nociceptive system in the infant male offspring through activation of the HPA axis peripheral link.

EFFECTS OF THE PINEAL GLAND IN UNILATERALLY ADRENALECTOMIZED RATS

1972 ◽  
Vol 70 (3) ◽  
pp. 438-444 ◽  
Author(s):  
Kenneth L. Dickson ◽  
David L. Hasty
Keyword(s):  
Pineal Gland ◽  
Plasma Levels ◽  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Zona Fasciculata ◽  
Inhibitory Effects ◽  
Plasma Corticosterone Level ◽  
Pineal Extract ◽  
Environmental Lighting ◽  
Adrenalectomized Rats

ABSTRACT The following experiments were undertaken to determine the effects that the pineal secretory substance might have on compensatory adrenal hypertrophy and corticosterone plasma levels in unilaterally adrenalectomized rats. It was demonstrated that blinded animals and animals administered with a bovine pineal extract exhibited a reduction in the percentage compensatory adrenal hypertrophy, a reduction in the thickness of the zona fasciculata, and a reduction in the plasma corticosterone level. These inhibitory effects were reversed by pinealectomy and ACTH injections, suggesting that the pineal gland, acting as a mediator for environmental lighting, might influence synthesis and/or release of ACTH.

Sign in / Sign up

Export Citation Format

Share Document