Glutamate and GABA levels and glutamate decarboxylase activity in brain regions of rats after prolonged treatment with alkali cations

1973 ◽  
Vol 29 (1) ◽  
pp. 68-69 ◽  
Author(s):  
Z. Gottesfeld ◽  
D. Samuel ◽  
Y. Icekson
Keyword(s):  
Glutamate Decarboxylase ◽  
Brain Regions ◽  
Prolonged Treatment ◽  
Decarboxylase Activity ◽  
Alkali Cations

Glutamate decarboxylase activity in brain regions of differentially-housed mice; a difference in the olfactory bulb

1980 ◽  
Vol 36 (7) ◽  
pp. 853-854 ◽  
Author(s):  
J. M. Blindermann ◽  
F. V. DeFeudis ◽  
M. Maitre ◽  
R. Misslin ◽  
P. Mandel
Keyword(s):  
Olfactory Bulb ◽  
Glutamate Decarboxylase ◽  
Brain Regions ◽  
Decarboxylase Activity

scholarly journals Effect of undernutrition in early life on glutamate decarboxylase activity in the adult brain

1972 ◽  
Vol 130 (1) ◽  
pp. 12P-12P ◽  
Author(s):  
B P F Adlard ◽  
J Dobbing ◽  
A Lynch ◽  
R Balázs ◽  
A P Reynolds
Keyword(s):  
Glutamate Decarboxylase ◽  
Early Life ◽  
Adult Brain ◽  
Decarboxylase Activity

scholarly journals Chronic L-Name-Treatment Produces Hypertension by Different Mechanisms in Peripheral Tissues and Brain: Role of Central eNOS

2020 ◽  
Vol 27 (1) ◽  
pp. 46-54
Author(s):  
Olga Pechanova ◽  
Stanislava Vrankova ◽  
Martina Cebova
Keyword(s):  
Time Course ◽  
Nuclear Factor Κb ◽  
Brain Regions ◽  
Prolonged Treatment ◽  
Enos Expression ◽  
Peripheral Tissues ◽  
Male Wistar Rats ◽  
Oxide Synthase ◽  
Nos Isoforms ◽  
The Brain

The goal of our study was to analyze the time course of the effect of NG-nitro-L-arginine methyl ester (L-NAME) on nitric oxide synthase (NOS) isoforms and nuclear factor–κB (NF-κB) protein expression, total NOS activity, and blood pressure (BP) in rats. Adult 12-week-old male Wistar rats were subjected to treatment with L-NAME (40 mg/kg/day) for four and seven weeks. BP was increased after 4- and 7-week L-NAME treatments. NOS activity decreased after 4-week-L-NAME treatment; however, the 7-week treatment increased NOS activity in the aorta, heart, and kidney, while it markedly decreased NOS activity in the brainstem, cerebellum, and brain cortex. The 4-week-L-NAME treatment increased eNOS expression in the aorta, heart, and kidney and this increase was amplified after 7 weeks of treatment. In the brain regions, eNOS expression remained unchanged after 4-week L-NAME treatment and prolonged treatment led to a significant decrease of eNOS expression in these tissues. NF-κB expression increased in both peripheral and brain tissues after 4 weeks of treatment and prolongation of treatment decreased the expression in the aorta, heart, and kidney. In conclusion, decreased expression of eNOS in the brain regions after 7-week L-NAME treatment may be responsible for a remarkable decrease of NOS activity in these regions. Since the BP increase persisted after 7 weeks of L-NAME treatment, we hypothesize that central regulation of BP may contribute significantly to L-NAME-induced hypertension.

Two approaches to the determination of glutamate decarboxylase activity in vivo

1979 ◽  
Vol 4 (5) ◽  
pp. 702
Author(s):  
L.P. Miller ◽  
J.R. Walters ◽  
D.L. Martin ◽  
N. Eng
Keyword(s):  
Glutamate Decarboxylase ◽  
Decarboxylase Activity
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