Effects of coronary occlusion on transmural distribution of blood flow in the interventricular septum and left ventricular free wall

1988 ◽  
Vol 83 (3) ◽  
pp. 229-237 ◽  
Author(s):  
K. B. Ramanathan ◽  
J. L. Wilson ◽  
D. M. Mirvis
Keyword(s):  
Blood Flow ◽  
Coronary Occlusion ◽  
Interventricular Septum ◽  
Left Ventricular ◽  
Ventricular Free Wall ◽  
Free Wall ◽  
Left Ventricular Free Wall

Myocardial blood flow and VO2 in conscious lambs with an aortopulmonary shunt

1987 ◽  
Vol 252 (4) ◽  
pp. H681-H686 ◽  
Author(s):  
G. P. Toorop ◽  
R. Hardjowijono ◽  
M. Dalinghaus ◽  
A. M. Gerding ◽  
J. H. Koers ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Left Ventricular ◽  
Ventricular Free Wall ◽  
Heart Weight ◽  
Rate Pressure Product ◽  
Free Wall ◽  
Left Ventricular Free Wall ◽  
Work Index ◽  
Correct Estimation

We measured myocardial blood flow (QLVFW) and O2 consumption of the left ventricular free wall (VO2, LVFW) in 13 chronically instrumented, 7-wk-old lambs with an aortopulmonary left-to-right shunt (S) and in 10 control lambs without a shunt (C). The measured VO2, LVFW was compared with the calculated values obtained by two predictive indexes, the rate-pressure product (RPP) and the pressure-work index (PWI). Measured VO2, LVFW in S lambs was significantly higher than in C lambs [983 +/- 104 (SE) vs. 475 +/- 57 mumol X min-1 X 100 g LV-1, P less than 0.001]. This was achieved by the significantly higher QLVFW (294 +/- 33 vs. 145 +/- 15 ml X min-1 X 100 g LV-1, P less than 0.002), since the arteriovenous O2 difference across the left ventricular free wall was similar in both groups of lambs. Total coronary blood flow per unit body mass in S lambs was higher than in C lambs (14.1 +/- 1.5 vs. 5.6 +/- 0.6 ml X min-1 X kg-1, P less than 0.001), not only because of the increased VO2, LVFW per unit muscle mass, but also because of the increased total heart weight (102.4 +/- 6.4 vs. 81.2 +/- 4.9 g, P less than 0.02). Correct estimation of VO2, LVFW by means of the RPP and the PWI was only possible in C lambs. In S lambs the estimated values were significantly lower than the measured ones.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Correlation between the periodontal treatment and ecocardiographic changes in adult dogs

Interação ◽  
2021 ◽  
Vol 21 (3) ◽  
pp. 43-57
Author(s):  
Daniel Paulino Júnior ◽  
Marina Queiroz Derruci ◽  
Leandro Zuccolotto Crivelenti ◽  
Brenda Faria Santos Gomes Parreira ◽  
Fernanda Gosuen Gonçalves Dias
Keyword(s):  
Left Ventricle ◽  
Periodontal Disease ◽  
Dental Treatment ◽  
Oral Treatment ◽  
Interventricular Septum ◽  
Left Ventricular ◽  
Periodontal Treatment ◽  
Ventricular Free Wall ◽  
Free Wall ◽  
Left Ventricular Free Wall

Periodontal disease is commonly diagnosed in dogs and has been associated with systemic lesions in several organs, however, studies correlating this oral condition with heart disease in the canine species are still scarce in the scientific literature. Thus, the objective of the present study was to evaluate such correlation in adult dogs, through serial echocardiographic exams and, nonetheless, to analyze the influence of dental treatment on cardiac function. For this, 60 dogs were used, distributed in two groups, the control (CG, n = 30: presence of periodontal disease, not submitted to oral treatment) and the treated (GT, n = 30: presence of periodontal disease and submitted to oral treatment). The animals of the CG were paired with those of the GT in terms of race, weight, age and degree of periodontal disease. Baseline echocardiographic examinations (D0) of the CG were performed and after 30 days (D30). In GT, examinations were also performed at D0 and D30, however, they were submitted to periodontal treatment after baseline measurements. The echocardiographic exams were performed at the Veterinary Cardiology Laboratory of the Veterinary Hospital of the University of Franca, to record and analyze the interventricular septum in diastole (SIVd), interventricular septum in systole (SIVs), diameter of the left ventricle in diastole (DVEd), left ventricular diameter in systole (EVDs), left ventricular free wall in diastole (PVEd) left ventricular free wall in systole (PVEs) shortening fraction of left ventricle (FS), final diastolic volume (VDF), final stroke volume (VSF), ejection fraction (EF), maximum pulmonary artery pressure gradient (max. GP AP) and left atrial and aortic artery diameter ratio (EA-AO). The results of the CG were statistically compared with those of the GT by means of simple analysis of variance (ANOVA). The data obtained regarding the SIVs, DVEd and PVEs parameters of the GT dogs at D30 showed a statistically significant decrease (p<0.05) when compared to the D30 of the CG. Thus, given the established methodology and the results found, it is possible to infer that periodontal treatment may benefit some cardiac parameters of adult dogs, improving their quality of life and survival.

Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats

1996 ◽  
Vol 271 (3) ◽  
pp. H1215-H1228 ◽  
Author(s):  
J. Kajstura ◽  
W. Cheng ◽  
R. Sarangarajan ◽  
P. Li ◽  
B. Li ◽  
...  
Keyword(s):  
Cell Death ◽  
Right Ventricle ◽  
Interventricular Septum ◽  
Left Ventricular ◽  
Ventricular Free Wall ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Free Wall ◽  
Fischer 344 Rats ◽  
Left Ventricular Free Wall ◽  
Fischer 344

To determine the effects of aging on myocyte cell death, Fischer 344 rats at 3, 7, 12, 16, and 24 mo of age were injected with myosin monoclonal antibody for the localization and quantification of necrotic myocyte cell death in the left ventricle, interventricular septum, and right ventricle. Conversely, the presence of DNA strand breaks in myocyte nuclei, indicative of programmed cell death, was evaluated by the terminal deoxynucleotidyl transferase assay and confirmed by DNA laddering. Myocyte necrosis, which involved nearly 1,000 myocytes in the left ventricular free wall at 3 mo, progressively increased with aging, reaching a value of 13,600 myocytes at 24 mo. Corre- sponding values in the interventricular septum were 300 and 9,400 myocytes. In the right ventricle, there were 270 necrotic myocytes at 3 mo and 9,000 at 24 mo. Programmed myocyte cell death was restricted to the left ventricular free wall and included 140 cells at 3 mo. This form of myocyte cell death increased at the subsequent age intervals, resulting in the involvement of 874 cells at 24 mo. The combination of necrosis and apoptosis in the left ventricular free wall was associated with 1,150 cells dying at 3 mo and 14,500 at 24 mo. In conclusion, myocyte cell death, apoptotic and necrotic in nature, constitutes an important determinant of the aging process, possibly mediating the occurrence of ventricular dysfunction and failure in the old heart.

Sign in / Sign up

Export Citation Format

Share Document