Lowering of blood ketone bodies induced by drugs preventing free fatty acid mobilization

1966 ◽  
Vol 22 (10) ◽  
pp. 664-664 ◽  
Author(s):  
A. Bizzi ◽  
M. T. Tacconi ◽  
S. Garattini
1977 ◽  
Vol 162 (1) ◽  
pp. 209-212 ◽  
Author(s):  
P Ferre ◽  
J P Pegorier ◽  
J Girard

Inhibition of gluconeogenesis with 3-mercaptopicolinate in suckling newborn rats caused a fall in blood [glucose], but no change in their high plasma [free fatty acid] and blood [ketone bodies]. Active gluconeogenesis seems to be more important than sparing of glucose by high concentrations of fat-derived substrates for the maintenance of normal blood [glucose] in suckling newborn rats.


2019 ◽  
Vol 70 (1) ◽  
pp. e522
Author(s):  
David Carneros Trujillo ◽  
Cristina Morilla ◽  
Emilio Jimenez ◽  
Matilde Bustos

1990 ◽  
Vol 22 (2) ◽  
pp. S85
Author(s):  
N. Warhaftig ◽  
R. K. Hetzler ◽  
E. Dowling ◽  
D. L. Thompson ◽  
A. Weltman

1983 ◽  
Vol 198 (6) ◽  
pp. 725-735 ◽  
Author(s):  
JÖRGEN NORDENSTRÖM ◽  
YVON A. CARPENTIER ◽  
JEFFREY ASKANAZI ◽  
ARNOLD P. ROBIN ◽  
DAVID H. ELWYN ◽  
...  

1973 ◽  
Vol 134 (2) ◽  
pp. 499-506 ◽  
Author(s):  
Oliver E. Owen ◽  
Helene Markus ◽  
Stuart Sarshik ◽  
Maria Mozzoli

1. Concentrations of ketone bodies, free fatty acids and chloride in fed, 24–120h-starved and alloxan-diabetic rats were determined in plasma and striated muscle. Plasma glucose concentrations were also measured in these groups of animals. 2. Intracellular metabolite concentrations were calculated by using chloride as an endogenous marker of extracellular space. 3. The mean intracellular ketone-body concentrations (±s.e.m.) were 0.17±0.02, 0.76±0.11 and 2.82±0.50μmol/ml of water in fed, 48h-starved and alloxan-diabetic rats, respectively. Mean (intracellular water concentration)/(plasma water concentration) ratios were 0.47, 0.30 and 0.32 in fed, 48h-starved and alloxan-diabetic rats respectively. The relationship between ketone-body concentrations in the plasma and intracellular compartments appeared to follow an asymptotic pattern. 4. Only intracellular 3-hydroxybutyrate concentrations rose during starvation whereas concentrations of both 3-hydroxybutyrate and acetoacetate were elevated in the alloxan-diabetic state. 5. During starvation plasma glucose concentrations were lowest at 48h, and increased with further starvation. 6. There was no significant difference in the muscle intracellular free fatty acid concentrations of fed, starved and alloxan-diabetic rats. Mean free fatty acid intramuscular concentrations (±s.e.m.) were 0.81±0.08, 0.98±0.21 and 0.91±0.10μmol/ml in fed, 48h-starved and alloxan-diabetic states. 7. The intracellular ketosis of starvation and the stability of free fatty acid intracellular concentrations suggests that neither muscle membrane permeability nor concentrations of free fatty acids per se are major factors in limiting ketone-body oxidation in these states.


Metabolism ◽  
1989 ◽  
Vol 38 (5) ◽  
pp. 439-444 ◽  
Author(s):  
Laurent Christin ◽  
Eric Ravussin ◽  
Clifton Bogardus ◽  
Barbara V. Howard

Sign in / Sign up

Export Citation Format

Share Document