Optimum level of combined adrenergic blockade for the experimental study of hemorrhagic shock

1969 ◽  
Vol 25 (8) ◽  
pp. 823-824
Author(s):  
G. Zierott ◽  
H. Riedwyl ◽  
P. Lundsgaard-Hansen
Keyword(s):  
Experimental Study ◽  
Hemorrhagic Shock ◽  
Optimum Level ◽  
Adrenergic Blockade

α-Adrenergic blockade restores normal fluid transport capacity of alveolar epithelium after hemorrhagic shock

1999 ◽  
Vol 277 (4) ◽  
pp. L760-L768 ◽  
Author(s):  
M. Laffon ◽  
L. N. Lu ◽  
K. Modelska ◽  
M. A. Matthay ◽  
J. F. Pittet
Keyword(s):  
Hemorrhagic Shock ◽  
Receptor Antagonist ◽  
Adrenergic Receptors ◽  
Fluid Transport ◽  
Alveolar Epithelium ◽  
Adrenergic Blockade ◽  
Transport Capacity ◽  
Alveolar Fluid Clearance ◽  
Normal Fluid ◽  
Pulmonary Inflammatory Response

Activation of β-adrenergic receptors in the lung is an important mechanism that can prevent alveolar flooding after brief but severe hemorrhagic shock. However, a neutrophil-dependent oxidant injury to the alveolar epithelium prevents the normal upregulation of alveolar fluid clearance by catecholamines after prolonged hemorrhagic shock. Because hemorrhage increases proinflammatory cytokine expression in the lung partly through the activation of α-adrenergic receptors, the objective of this study was to determine whether α-adrenergic blockade would restore the normal fluid transport capacity of the alveolar epithelium after hemorrhagic shock. Hemorrhagic shock was associated with a significant increase of interleukin-1β (IL-1β) concentration in the lung and a failure of the alveolar epithelium to respond to β-adrenergic agonists, with the upregulation of vectorial fluid transport despite intra-alveolar administration of exogenous catecholamines. In contrast, catecholamine-mediated upregulation of alveolar liquid clearance was restored by pretreatment with phentolamine, an α-adrenergic-receptor antagonist. Phentolamine pretreatment also significantly attenuated the shock-mediated increase of IL-1β concentration in the lung. Additional experiments demonstrated that the inhibition of IL-1β binding to its receptor by the administration of IL-1-receptor antagonist restored the normal fluid transport capacity of the alveolar epithelium after hemorrhagic shock. In summary, the results of these studies indicate that the activation of α-adrenergic receptors after hemorrhagic shock prevents the β-adrenergic-dependent upregulation of alveolar fluid clearance by modulating the severity of the pulmonary inflammatory response.

Fluid therapy in hemorrhagic shock (an experimental study)

1978 ◽  
Vol 62 (6) ◽  
pp. 920
Author(s):  
Khoo Boo-Chai ◽  
K. Singh ◽  
D. P. Kapur
Keyword(s):  
Experimental Study ◽  
Hemorrhagic Shock ◽  
Fluid Therapy

scholarly journals Hypertonic, Normal Saline or Neither: Which One is better in Uncontrolled Hemorrhagic Shock? Experimental Study on Goat

2013 ◽  
Vol 19 (6) ◽  
pp. 500-506 ◽  
Author(s):  
Morteza Saeedi ◽  
houman hajseyedjavadi ◽  
samad shamsvahdati ◽  
vahid eslami ◽  
mohamad mokhtarpour ◽  
...  
Keyword(s):  
Experimental Study ◽  
Hemorrhagic Shock ◽  
Normal Saline

Effect of adrenergic blockade on the metabolic response to hemorrhagic shock

1968 ◽  
Vol 25 (4) ◽  
pp. 384-389 ◽  
Author(s):  
D. F. J. Halmagyi ◽  
M. H. Irving ◽  
D. Varga
Keyword(s):  
Hemorrhagic Shock ◽  
Metabolic Response ◽  
Adrenergic Blockade

ACUTE HEMODYNAMIC EFFECTS OF INDUCED HYPOTHERMIA IN HEMORRHAGIC SHOCK: AN EXPERIMENTAL STUDY IN THE PIG

Shock ◽  
2001 ◽  
Vol 15 (1) ◽  
pp. 60-64 ◽  
Author(s):  
Andreas Wladis ◽  
Robert G. Hahn ◽  
Hans Hjelmqvist ◽  
Bo Brismar ◽  
Thomas B. Kjellström
Keyword(s):  
Experimental Study ◽  
Hemorrhagic Shock ◽  
Induced Hypothermia ◽  
Hemodynamic Effects
Sign in / Sign up

Export Citation Format

Share Document