Blockage of the hepatic-artery blood flow by biodegradable microspheres (Spherex®) combined with local hyperthermia in the treatment of experimental liver tumors in rats

1985 ◽  
Vol 109 (1) ◽  
pp. 38-41 ◽  
Author(s):  
Christian Erichsen ◽  
Magnus Bolmsjö ◽  
Anders Hugander ◽  
Per-Ebbe Jönsson
Keyword(s):  
Blood Flow ◽  
Hepatic Artery ◽  
Liver Tumors ◽  
Biodegradable Microspheres ◽  
Artery Blood Flow ◽  
Local Hyperthermia ◽  
Experimental Liver

scholarly journals Intraoperative evaluation of the hepatic artery blood flow during pancreatoduodenectomy (HEPARFLOW Study)

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S305
Author(s):  
M. Al-Saeedi ◽  
L. Frank-Moldzio ◽  
M. Klauß ◽  
P. Mayer ◽  
T. Bruckner ◽  
...  
Keyword(s):  
Blood Flow ◽  
Hepatic Artery ◽  
Artery Blood Flow ◽  
Intraoperative Evaluation

Factors influencing control of arterial circulation in the liver of the dog

1963 ◽  
Vol 205 (6) ◽  
pp. 1260-1264 ◽  
Author(s):  
Roy Cohn ◽  
Samuel Kountz
Keyword(s):  
Blood Flow ◽  
Hepatic Artery ◽  
Artery Blood Flow ◽  
Portal Venous Flow ◽  
Hepatic Arterial Flow ◽  
Experimental Conditions ◽  
Venous Flow ◽  
Arterial Circulation ◽  
Factors Influencing ◽  
Intrinsic Regulation

Measurements were made of the hepatic arterial flow in thirty-one mongrel dogs by the use of the electromagnetic square wave flowmeter under the following experimental conditions: hepatic arterial neurectomy, portal venous flow reductions, portal venous flow elimination and diversion, and systemic acidosis and alkalosis. The findings suggest that the periarterial nerves about the hepatic artery influence the intrinsic regulation of hepatic artery blood flow only in the presence of severely reduced portal venous flow.

Compensatory Hepatic Artery Blood Flow Increase Prevents Liver Injury During Modified Multivisceral Transplant Evisceration

2017 ◽  
Vol 101 ◽  
pp. S20
Author(s):  
Bernardo Ketzer ◽  
Rodrigo Vincenzi ◽  
Ana Maria M. Coelho ◽  
Kátia R. Leite ◽  
Flavio H. Galvao ◽  
...  
Keyword(s):  
Blood Flow ◽  
Liver Injury ◽  
Hepatic Artery ◽  
Artery Blood Flow ◽  
Blood Flow Increase

Intraoperative Hepatic Artery Blood Flow Predicts Early Hepatic Artery Thrombosis After Liver Transplantation

2012 ◽  
Vol 44 (7) ◽  
pp. 2078-2081 ◽  
Author(s):  
L.M. Marín-Gómez ◽  
C. Bernal-Bellido ◽  
J.M. Álamo-Martínez ◽  
F.M. Porras-López ◽  
G. Suárez-Artacho ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Blood Flow ◽  
Hepatic Artery ◽  
Hepatic Artery Thrombosis ◽  
Artery Blood Flow ◽  
Artery Thrombosis

A New Catheter for Tumor Targeting With Radioactive Microspheres in Representative Hepatic Artery Systems. Part I: Impact of Catheter Presence on Local Blood Flow and Microsphere Delivery

2012 ◽  
Vol 134 (5) ◽  
Author(s):  
C. Kleinstreuer ◽  
C. A. Basciano ◽  
E. M. Childress ◽  
A. S. Kennedy
Keyword(s):  
Blood Flow ◽  
Hepatic Artery ◽  
Liver Tumors ◽  
Three Dimensional ◽  
Radioactive Microspheres ◽  
Local Blood Flow ◽  
Catheter Position ◽  
Cross Sectional ◽  
Injection Speed ◽  
90Y Microspheres

Building on previous studies in which the transport and targeting of 90Y microspheres for liver tumor treatment were numerically analyzed based on medical data sets, this two-part paper discusses the influence of an anchored, radially adjustable catheter on local blood flow and microsphere delivery in an idealized hepatic artery system (Part I). In Part II a patient-inspired case study with necessary conditions for optimal targeting of radioactive microspheres (i.e., yttrium 90) onto liver tumors is presented. A new concept of optimal catheter positioning is introduced for selective targeting of two daughter-vessel exits potentially connected to liver tumors. Assuming laminar flow in rigid blood vessels with an anchored catheter in three controlled positions, the transient three-dimensional (3D) transport phenomena were simulated employing user-enhanced engineering software. The catheter position as well as injection speed and delivery function may influence fluid flow and particle transport. Although the local influences of the catheter may not be negligible, unique cross-sectional particle release zones exist, with which selectively the new controlled targeting methodology would allow optimal microsphere delivery. The insight gained from this analysis paves the way for improved design and testing of a smart microcatheter (SMC) system as well as new investigations leading to even more successful treatment with 90Y microspheres or combined internal radiation and chemotherapy.

β-Blockade with propranolol and hepatic artery blood flow in patients with cirrhosis

Hepatology ◽  
1989 ◽  
Vol 10 (3) ◽  
pp. 269-272 ◽  
Author(s):  
Ricardo Mastai ◽  
Jaime Bosch ◽  
Jordi Bruix ◽  
Miguel Navasa ◽  
David Kravetz ◽  
...  
Keyword(s):  
Blood Flow ◽  
Hepatic Artery ◽  
Artery Blood Flow

scholarly journals The Influence of Portal Deviation on the Effect of Repeat Dearterializations of a Transplantable Adenocarcinoma to the Rat Liver

HPB Surgery ◽  
1994 ◽  
Vol 8 (1) ◽  
pp. 37-41
Author(s):  
L. Q. Wang ◽  
B. G. Persson ◽  
S. Bengmark
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Hepatic Artery ◽  
Liver Damage ◽  
Tumour Growth ◽  
Portal Blood Flow ◽  
Therapeutic Benefit ◽  
Portal Blood ◽  
Liver Tumours ◽  
Experimental Liver

As liver tumours receive some of their blood supply from the portal vein, we wanted to illustrate the influence of portal blood flow in combination with dearterialization in the treatment of liver tumours. Forty male, inbred Wistar/Furth rats with an adenocarcinoma transplanted to the liver were treated with various inflow occlusions repeated daily for 5 days. Deviation of the portal blood flow alone with an end-side porto-caval shunt did not alter the tumour growth (p = 0.089). Thirty min of repeat dearterializations was potentiated by portal deviation so that tumour growth was delayed (p = 0.004). However, repeat dearterializations for 60 min in portal deviated rats induced irreversible liver damage and all rats died in a few days. Repeated dearterializations for 60 minutes alone retarded the tumour growth as efficiently (p = 0.007). Simultaneous occlusion of the hepatic artery and the portal vein for 30 minutes with a side-side porto-caval shunted (total devascularization) did not affect tumour growth (p = 0.154). Liver aminotransferases (ASAT and ALAT) were substantially increased following dearterialization for 30 min in rats with either an end-side or a side-side porto-caval shunt. Dearterialization for 60 min in rats with end-side porto-caval shunts gave a further release of ASAT and ALAT.In conclusion, portal deviation did not augment the therapeutic benefit of repeat dearterializations for the treatment of this experimental liver tumour. Repeat dearterializations alone seemed to be a feasible and efficient therapy for liver tumours.

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