Effect of basic protein from human central nervous system myelin on lipid bilayer structure

1978 ◽  
Vol 39 (1) ◽  
pp. 75-96 ◽  
Author(s):  
J. M. Boggs ◽  
M. A. Moscarello
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Lipid Bilayer ◽  
Basic Protein ◽  
Bilayer Structure ◽  
Human Central Nervous System

scholarly journals Partial characterization of the phosphotransferase system of human central-nervous-system myelin

1983 ◽  
Vol 209 (3) ◽  
pp. 789-795 ◽  
Author(s):  
N C Wu ◽  
J E Yourist ◽  
W D Rector ◽  
F Ahmad
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cyclic Nucleotide ◽  
Basic Protein ◽  
Phosphotransferase System ◽  
Human Central Nervous System ◽  
Bivalent Cation ◽  
Triton X ◽  
Modest Activity

The phosphotransferase system of human central-nervous-system myelin was investigated. Evidence obtained indicated the presence of at least two different phosphotransferase systems (cyclic nucleotide-dependent and -independent) in myelin, which were found to be firmly associated with the membrane. The cyclic AMP-dependent kinase of myelin and white-matter cytosol preferentially phosphorylated certain histone fractions and displayed only modest activity with basic protein as substrate. On the other hand, the cyclic nucleotide-independent system showed specificity toward basic protein. Its activity was not only dependent on Mg2+ but it was greatly enhanced by this bivalent cation. Whereas the cyclic nucleotide-dependent kinase could be extracted with buffers containing Triton X-100, the bivalent cation-regulated kinase resisted solubilization from myelin under these conditions.

Sex Differences in Cognition

2019 ◽  
pp. 41-66
Author(s):  
Elizabeth Hampson
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Sex Differences ◽  
Spatial Cognition ◽  
Sex Steroids ◽  
Cognitive Functions ◽  
Laboratory Animals ◽  
Human Central Nervous System ◽  
The Brain

Organizational and activational effects of sex steroids were first discovered in laboratory animals, but these concepts extend to hormonal actions in the human central nervous system. This chapter begins with a brief overview of how sex steroids act in the brain and how the organizational-activational hypothesis originated in the field of endocrinology. It then reviews common methods used to study these effects in humans. Interestingly, certain cognitive functions appear to be subject to modification by sex steroids, and these endocrine influences may help explain the sex differences often seen in these functions. The chapter considers spatial cognition as a representative example because the spatial family of functions has received the most study by researchers interested in the biological roots of sex differences in cognition. The chapter reviews evidence that supports an influence of both androgens and estrogens on spatial functions, and concludes with a glimpse of where the field is headed.

Humoral immune responses within the human central nervous system following systemic immunization

1986 ◽  
Vol 11 (3) ◽  
pp. 205-214 ◽  
Author(s):  
Magnhild Sandberg-Wollheim ◽  
Burton Zweiman ◽  
Arnold I. Levinson ◽  
Robert P. Lisak
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Immune Responses ◽  
Human Central Nervous System ◽  
Humoral Immune ◽  
Humoral Immune Responses

Simulations of Synaptic Transmission Using Lattice Boltzmann Methods

2002 ◽  
Author(s):  
Mehrak Mahmoudi ◽  
Piroz Zamankhan ◽  
William Polashenski
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Theoretical Model ◽  
Lattice Boltzmann ◽  
Chemical Substance ◽  
Human Central Nervous System ◽  
Lattice Boltzmann Methods ◽  
Nerve Impulses ◽  
System A ◽  
The Central Nervous System

The nervous system remains one of the least understood biological structures due in large part to the enormous complexity of this organ. A theoretical model for the transfer of nerve impulses would be valuable for the analysis of various phenomena in the nervous system, which are difficult to study by experiments. The central nervous system is composed of more than 100 billion neurons, through which information is transmitted via nerve impulses. Nerve impulses are not immediately apparent since each impulse may be blocked during transmission, changed from a single impulse into repetitive impulse, or integrated with impulses from other neurons to form highly intricate patterns. In the human central nervous system, a neuron secretes a chemical substance called a neurotransmitter at the synapse, and this transmitter in turn acts on another neuron to cause excitation, inhibition, or some other modification of its sensitivity.

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