Separation of ionic currents in the somatic membrane of frog sensory neurons

1984 ◽  
Vol 78 (1) ◽  
pp. 19-28 ◽  
Author(s):  
S. Ishizuka ◽  
K. Hattori ◽  
N. Akaike
Keyword(s):  
Sensory Neurons ◽  
Ionic Currents ◽  
Somatic Membrane

scholarly journals Activity-dependent enhancement of presynaptic facilitation provides a cellular mechanism for the temporal specificity of classical conditioning in Aplysia.

1994 ◽  
Vol 1 (4) ◽  
pp. 243-257
Author(s):  
G A Clark ◽  
R D Hawkins ◽  
E R Kandel
Keyword(s):  
Action Potential ◽  
Classical Conditioning ◽  
Sensory Neurons ◽  
Cell Activity ◽  
Critical Time ◽  
Ionic Currents ◽  
Temporal Specificity ◽  
The Us ◽  
Activity Dependent ◽  
Presynaptic Facilitation

A hallmark of many forms of classical conditioning is a precise temporal specificity: Learning is optimal when the conditioned stimulus (CS) slightly precedes the unconditioned stimulus (US), but the learning is degraded at longer or backward intervals, consistent with the notion that conditioning involves learning about predictive relationships in the environment. To further examine the cellular mechanisms contributing to the temporal specificity of classical conditioning of the siphon-withdrawal response in Aplysia, we paired action potential activity in siphon sensory neurons (the neural CS) with tail nerve shock (the US) at three critical time points. We found that CS-US pairings at short (0.5 sec) forward intervals produced greater synaptic facilitation at sensorimotor connections than did either 0.5-sec backward pairings or longer (5 sec) forward pairings, as reflected in a differential increase in both the amplitude and rate of rise of the synaptic potential. In the same preparations, forward pairings also differentially reduced the sensory neuron afterhyperpolarization relative to backward pairings, suggesting that changes in synaptic efficacy were accompanied by temporally specific changes in ionic currents in the sensory neurons. Additional experiments demonstrated that short forward pairings of sensory cell activity and restricted applications of the neuromodulatory transmitter serotonin (normally released by the US) differentially enhanced action potential broadening in siphon sensory neurons, relative to backward pairings. Taken together, these results suggest that temporally specific synaptic enhancement engages both spike-width-dependent and spike-width-independent facilitatory processes and that activity-dependent enhancement of presynaptic facilitation may contribute to both the CS-US sequence and proximity requirements of conditioning.

Voltage-activated potassium currents in the somatic membrane of sensory neurons of early postnatal rats

1998 ◽  
Vol 30 (1) ◽  
pp. 19-27
Author(s):  
D. A. Vasilyev ◽  
N. S. Veselovsky ◽  
S. A. Fedulova
Keyword(s):  
Sensory Neurons ◽  
Potassium Currents ◽  
Somatic Membrane ◽  
Postnatal Rats

scholarly journals Sphingosine 1-Phosphate to p38 Signaling via S1P1 Receptor and Gαi/o Evokes Augmentation of Capsaicin-Induced Ionic Currents in Mouse Sensory Neurons

2014 ◽  
Vol 10 ◽  
pp. 1744-8069-10-74 ◽  
Author(s):  
Michiel Langeslag ◽  
Serena Quarta ◽  
Michael G Leitner ◽  
Michaela Kress ◽  
Norbert Mair
Keyword(s):  
Sensory Neurons ◽  
Ionic Currents ◽  
S1p1 Receptor ◽  
Sphingosine 1 Phosphate

Steady-state characteristics of the proton receptor in the somatic membrane of rat sensory neurons

1984 ◽  
Vol 15 (6) ◽  
pp. 469-474
Author(s):  
A. O. Korkushko ◽  
O. A. Kryshtal' ◽  
N. I. Chernevskaya
Keyword(s):  
Steady State ◽  
Sensory Neurons ◽  
Somatic Membrane

Serotonin- and proton-induced and modified ionic currents in frog sensory neurons

1995 ◽  
Vol 40 (3) ◽  
pp. 387-395 ◽  
Author(s):  
M. Philippi ◽  
L. Vyklický ◽  
D. P. Kuffler ◽  
Richard K. Orkand
Keyword(s):  
Sensory Neurons ◽  
Ionic Currents

Cutaneous and Colonic Rat DRG Neurons Differ With Respect to Both Baseline and PGE2-Induced Changes in Passive and Active Electrophysiological Properties

2004 ◽  
Vol 91 (6) ◽  
pp. 2524-2531 ◽  
Author(s):  
Michael S. Gold ◽  
Richard J. Traub
Keyword(s):  
Sensory Neurons ◽  
Ionic Currents ◽  
Therapeutic Interventions ◽  
Prostaglandin E ◽  
Drg Neurons ◽  
Patch Clamp Recording ◽  
Electrophysiological Properties ◽  
Adult Rat ◽  
Body Regions ◽  
Induced Changes

This study was designed to test the hypotheses that pain syndromes associated with specific body regions reflect unique properties of sensory neurons innervating these regions and/or unique responses of these afferents to tissue damage. Acutely dissociated adult rat dorsal root ganglia (DRG) neurons retrogradely labeled from either the colon or the glabrous skin of the hindpaw were studied by whole cell patch-clamp recording in current-clamp mode. Two populations of colonic afferent neurons were studied: pelvic afferents (arising from L6, S1, and S2 DRG = LS DRG) and hypogastric/lumbar colonic afferents (arising from T13, L1, and L2 DRG = TL DRG). Passive and active electrophysiological properties were studied before and after application prostaglandin E2 (PGE2). We observed marked differences between cutaneous and colonic sensory neurons with respect to baseline passive and active electrophysiological properties as well as both the magnitude and pattern of PGE2-induced changes in excitability, passive, and active properties. There were also significant differences between TL and LS neurons with respect to baseline and PGE2-induced changes in several passive and active electrophysiological properties. Our results suggest that differences between cutaneous and colonic neurons reflect differences in pattern and/or density of ionic currents present in the plasma membrane. More interestingly, the ionic currents underlying the PGE2-induced sensitization of cutaneous neurons appeared to differ from those underlying the sensitization of colonic neurons. The implication of this observation is that it may be possible, in fact necessary, to treat pain arising from specific body regions with unique therapeutic interventions.

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