Assembly and sealing of tight junctions: Possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin

1991 ◽  
Vol 122 (3) ◽  
pp. 193-202 ◽  
Author(s):  
M. S. Balda ◽  
L. González-Mariscal ◽  
R. G. Contreras ◽  
M. Macias-Silva ◽  
M. E. Torres-Marquez ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phospholipase C ◽  
Tight Junctions ◽  
G Proteins ◽  
C Protein ◽  
Kinase C

Leptin Constrains Phospholipase C-Protein Kinase C-Induced Insulin Secretion via a Phosphatidylinositol 3-Kinase-Dependent Pathway

2003 ◽  
Vol 228 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Joo-Won Lee ◽  
Andrew G. Swick ◽  
Dale R. Romsos
Keyword(s):  
Protein Kinase C ◽  
Insulin Secretion ◽  
Protein Kinase ◽  
Phospholipase C ◽  
Phosphatidylinositol 3 Kinase ◽  
C Protein ◽  
Kinase C ◽  
Pka Pathway ◽  
Stimulation Of ◽  
Phosphatidylinositol 3

Leptin-deficient Lepob/Lepob mice hypersecrete insulin in response to acetylcholine stimulation of the phospholipase C-protein kinase C (PLC-PKC) pathway, and leptin constrains this hypersecretion. Leptin has been reported to activate phosphatidylinositol 3-kinase (PI 3-K) and subsequently phosphodiesterase (PDE) to impair protein kinase A (PKA)-induced insulin secretion from cultured islets of neonatal rats. We determined if PKA-induced insulin secretion was also hyperresponsive in Islets from Lepob/Lepob mice, and if leptin impaired this pathway in islets from these mice. Additionally, the possible role for PI 3-K and PDE in leptin-induced control of acetylcholine-induced insulin secretion was examined. Stimulation of Insulin secretion with GLP-1, forskolin (an activator of adenylyl cyclase), or IBMX (an inhibitor of PDE) did not cause hypersecretion of insulin from islets of young Lepob/Lepob mice, and leptin did not inhibit GLP-1-induced insulin secretion from islets of these mice. Inhibition of PDE with IBMX also did not block leptin-induced inhibition of acetylcholine-mediated insulin secretion from islets of Lepob/Lepob mice. But, preincubation of islets with wortmannin, an Inhibitor of PI 3-K activity, blocked the ability of leptin to constrain acetylcholine-induced insulin secretion from islets of Lepob/Lepob mice. We conclude that the capacity of the PKA pathway to stimulate insulin secretion is not increased in islets from young Lepob/Lepob mice, and that leptin does not regulate this pathway in islets from mice. Leptin may stimulate PI 3-K to constrain PLC-PKC-induced insulin secretion from Islets of Lepob/Lepob mice.

Phospholipase C-protein kinase C mediated phospholipase D activation pathway is involved in tamoxifen induced apoptosis

2003 ◽  
Vol 89 (3) ◽  
pp. 520-528 ◽  
Author(s):  
Soo-Jung Ahn ◽  
Mee-Sup Yoon ◽  
Shin Hyuk ◽  
Wonshik Han ◽  
Yong-Dal Yoon ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phospholipase C ◽  
Phospholipase D ◽  
C Protein ◽  
Activation Pathway ◽  
Kinase C ◽  
Induced Apoptosis

Leishmania amazonensis: Heme stimulates (Na++K+)ATPase activity via phosphatidylinositol-specific phospholipase C/protein kinase C-like (PI-PLC/PKC) signaling pathways

2010 ◽  
Vol 124 (4) ◽  
pp. 436-441 ◽  
Author(s):  
Elmo Eduardo Almeida-Amaral ◽  
Viviane Carrozino Cardoso ◽  
Fernanda Gomes Francioli ◽  
José Roberto Meyer-Fernandes
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Atpase Activity ◽  
Signaling Pathways ◽  
Phospholipase C ◽  
Leishmania Amazonensis ◽  
C Protein ◽  
Kinase C ◽  
Pkc Signaling

Phospholipase C/Protein Kinase C Pathway is Essential for Corneal Re-epithelialization Induced by Ap4A

2011 ◽  
Vol 36 (12) ◽  
pp. 1108-1115 ◽  
Author(s):  
Aránzazu Mediero ◽  
Almudena Crooke ◽  
Ana Guzmán-Aránguez ◽  
Jesús Pintor
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phospholipase C ◽  
C Protein ◽  
Kinase C
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