Pressure dependence of the sodium currents of squid giant axon

1982 ◽  
Vol 69 (1) ◽  
pp. 23-34 ◽  
Author(s):  
F. Conti ◽  
R. Fioravanti ◽  
J. R. Segal ◽  
W. Stühmer
1984 ◽  
Vol 11 (2) ◽  
pp. 137-147 ◽  
Author(s):  
F. Conti ◽  
I. Inoue ◽  
F. Kukita ◽  
W. St�hmer

1982 ◽  
Vol 69 (1) ◽  
pp. 35-40 ◽  
Author(s):  
F. Conti ◽  
R. Fioravanti ◽  
J. R. Segal ◽  
W. Stühmer

1990 ◽  
Vol 240 (1299) ◽  
pp. 425-432 ◽  

A series-parallel model of the kinetics of the voltage-gated sodium channel is described. It goes some way towards reconciling the timecourses of the gating and macroscopic sodium currents in the squid giant axon with the molecular structure of the channel.


Author(s):  
J. Metuzals

It has been demonstrated that the neurofibrillary tangles in biopsies of Alzheimer patients, composed of typical paired helical filaments (PHF), consist also of typical neurofilaments (NF) and 15nm wide filaments. Close structural relationships, and even continuity between NF and PHF, have been observed. In this paper, such relationships are investigated from the standpoint that the PHF are formed through posttranslational modifications of NF. To investigate the validity of the posttranslational modification hypothesis of PHF formation, we have identified in thin sections from frontal lobe biopsies of Alzheimer patients all existing conformations of NF and PHF and ordered these conformations in a hypothetical sequence. However, only experiments with animal model preparations will prove or disprove the validity of the interpretations of static structural observations made on patients. For this purpose, the results of in vitro experiments with the squid giant axon preparations are compared with those obtained from human patients. This approach is essential in discovering etiological factors of Alzheimer's disease and its early diagnosis.


1990 ◽  
Vol 1023 (3) ◽  
pp. 421-435 ◽  
Author(s):  
Harvey M. Fishman ◽  
Kirti P. Tewari ◽  
Philip G. Stein
Keyword(s):  

2004 ◽  
Vol 207 (2) ◽  
pp. 164-164
Author(s):  
Michael P. Conley ◽  
Marcus K. Jang ◽  
Joseph A. DeGiorgis ◽  
Elaine L. Bearer

1978 ◽  
Vol 54 (6) ◽  
pp. 310-315 ◽  
Author(s):  
Tohru YOSHIOKA ◽  
Toshifumi TAKENAKA ◽  
Hidenori HORIE ◽  
Hiroko INOUE ◽  
Kimie INOMATA

2002 ◽  
Vol 203 (2) ◽  
pp. 189-190 ◽  
Author(s):  
Antonio Giuditta ◽  
Maria Eyman ◽  
Barry B. Kaplan

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