Interaction of alkyl ammonium derivatives with red cells: Hemolysis and sodium pump inhibition studies

1980 ◽  
Vol 55 (2) ◽  
pp. 123-131 ◽  
Author(s):  
R. A. Klein ◽  
J. C. Ellory
Keyword(s):  
Sodium Pump ◽  
Red Cells ◽  
Sodium Pump Inhibition ◽  
Alkyl Ammonium ◽  
Inhibition Studies

Effects of sodium pump inhibition on the relaxation induced by synthetic Atrial Natriuretic Factor (ANF) and sodium nitroprusside

1985 ◽  
Vol 10 ◽  
pp. 110-112
Author(s):  
Michel Auguet ◽  
Sylvie Delaflotte ◽  
Ricardo Garay ◽  
Marc Cantin ◽  
François Clostre ◽  
...  
Keyword(s):  
Sodium Nitroprusside ◽  
Atrial Natriuretic Factor ◽  
Sodium Pump ◽  
Natriuretic Factor ◽  
Sodium Pump Inhibition ◽  
Atrial Natriuretic

Reducing the Late Sodium Current Improves Cardiac Function during Sodium Pump Inhibition by Ouabain

2011 ◽  
Vol 337 (2) ◽  
pp. 513-523 ◽  
Author(s):  
Kirsten Hoyer ◽  
Yejia Song ◽  
Desuo Wang ◽  
Dillon Phan ◽  
James Balschi ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Sodium Pump ◽  
Sodium Current ◽  
Late Sodium Current ◽  
Sodium Pump Inhibition

Sensitive assay for sodium pump inhibition

1994 ◽  
Vol 40 (8) ◽  
pp. 1595-1596 ◽  
Author(s):  
Q F Tao ◽  
P A Soszynski ◽  
N K Hollenberg ◽  
S W Graves
Keyword(s):  
Sodium Pump ◽  
Sensitive Assay ◽  
Sodium Pump Inhibition

scholarly journals Relation of sodium pump inhibition to positive inotropy at low concentrations of ouabain in rat heart muscle.

1985 ◽  
Vol 360 (1) ◽  
pp. 149-160 ◽  
Author(s):  
I Grupp ◽  
W B Im ◽  
C O Lee ◽  
S W Lee ◽  
M S Pecker ◽  
...  
Keyword(s):  
Heart Muscle ◽  
Rat Heart ◽  
Sodium Pump ◽  
Positive Inotropy ◽  
Low Concentrations ◽  
Sodium Pump Inhibition

Abnormalities in the Sodium Pump of Erythrocytes from Patients with Hyperthyroidism

1970 ◽  
Vol 38 (1) ◽  
pp. 49-61 ◽  
Author(s):  
E. K. M. Smith ◽  
Pamela D. Samuel
Keyword(s):  
Sodium Pump ◽  
Sodium Concentration ◽  
Intracellular Sodium ◽  
Red Cells ◽  
Control Group ◽  
Active Sodium ◽  
Sodium Efflux ◽  
Control Subjects ◽  
Intracellular Sodium Concentration ◽  
The Mean

1. Intracellular cation composition has been measured in the red cells from twenty patients with hyperthyroidism. The mean concentration of sodium was 11·18 m-mole/l red cells; in sixty normal control subjects the mean red cell sodium level was 7·04 m-mole/l. The difference between these two groups was highly significant. There was no measurable difference between the potassium concentration and water content of red cells from thyrotoxic and control groups. 2. Measurements of active sodium efflux were carried out in red cells from ten hyperthyroid subjects and their matched controls. The rate constant for active sodium efflux was significantly lower in the patients than the control group. 3. The total amount of sodium actively pumped from red cells in 1 hr was significantly higher in the patients than the controls. 4. The total amount of sodium moving out of the red cells, both actively and by exchange diffusion, matched the total influx of sodium. This was true for control subjects and those with hyperthyroidism and this would support the view that the intracellular sodium concentration is constant and represents the result of a balance between influx and efflux. In hyperthyroidism this balance persists, but with an abnormally high intracellular sodium concentration. 5. There was a linear relationship between the cell sodium content and the active transport of sodium from the cell in control and hyperthyroid subjects. 6. Triiodothyronine did not produce any change in sodium transport by normal red cells in vitro. 7. It is concluded that there is a depression of the activity of the sodium pump in the red cells of hyperthyroid subjects. This allows the resting intracellular sodium concentration to rise until a new steady state is reached. Evidence is given that these changes are reversed when hyperthyroidism is corrected.

Sodium Pump Activity in Uremic Erythrocytes: A Microcalorimetric Study

1992 ◽  
Vol 15 (3) ◽  
pp. 135-138 ◽  
Author(s):  
P. Gallice ◽  
H. Kovacic ◽  
M. Baz ◽  
Y. Berland ◽  
R. Elsen ◽  
...  
Keyword(s):  
Heat Production ◽  
Healthy Subjects ◽  
Sodium Pump ◽  
Age Distribution ◽  
Lower Activity ◽  
Flow Microcalorimetry ◽  
Pump Activity ◽  
Uremic Patients ◽  
The Difference ◽  
Sodium Pump Inhibition

Erythrocyte thermogenesis was studied by flow microcalorimetry in 25 healthy subjects and 27 uremic patients. The heat production (HP) from cells in plasma, decrease in HP induced by ouabain (a specific sodium pump inhibitor) and index of rate response to ouabain action were measured. HP was higher in uremic patients than controls. Sodium pump inhibition with ouabain induced the same decrease in HP in the two groups. The index of rate response to ouabain action was lower in uremic patients than in controls. The difference in total HP may be due to a different age distribution of erythrocytes. Mean sodium pump activity was identical in the two groups, but some patients had lower activity than controls. Ouabain seems to act more slowly in many patients than in controls, perhaps because of hindered binding of the inhibitor.

Sodium pump inhibition by sulfhydryl inhibitors and myocardial contractility

1978 ◽  
Vol 302 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Kyosuke Temma ◽  
Tai Akera ◽  
David D. Ku ◽  
Theodore M. Brody
Keyword(s):  
Myocardial Contractility ◽  
Sodium Pump ◽  
Sodium Pump Inhibition
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