Fosfomycin trometamol in a single dose versus seven days nitrofurantoin in the treatment of acute uncomplicated urinary tract infections in women

1993 ◽  
Vol 15 (6) ◽  
pp. 257-262 ◽  
Author(s):  
E. Pienbroek ◽  
J. Hermans ◽  
A. A. Kaptein ◽  
J. D. Mulder
Keyword(s):  
Single Dose ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Fosfomycin Trometamol ◽  
Tract Infections

scholarly journals Urinary Tract Infections among Indonesian Pregnant Women and Its Susceptibility Pattern

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Yeva Rosana ◽  
Dwiana Ocviyanti ◽  
Melissa Halim ◽  
Friza Yossy Harlinda ◽  
Rahmah Amran ◽  
...  
Keyword(s):  
Single Dose ◽  
Urinary Tract ◽  
Pregnant Women ◽  
Urinary Tract Infections ◽  
Asymptomatic Bacteriuria ◽  
In Vitro Susceptibility ◽  
E Coli ◽  
Fosfomycin Trometamol ◽  
Tract Infections

Pregnant women are usually at risk of urinary tract infections (UTIs) such as asymptomatic bacteriuria. In the current multidrug-resistance era, appropriate diagnosis and treatment should be provided to avoid complications in pregnant women in developing countries, which have limited facilities, such as Indonesia. The aim of this study was to evaluate in vitro susceptibility tests. Urinary isolates were collected from 715 pregnant women who visited eight Community Health Centers in Jakarta, Indonesia, between 2015 and 2017. We identified bacterial uropathogens from samples that were positive for nitrite/leukocyte esterase (LE), using two types of VITEK cards. Since noncompliance among patients is a major problem, fosfomycin-trometamol 3 g single-dose sachets were given to the patients, and the side effects of the medication and neonatal outcomes were reported. Asymptomatic bacteriuria was found in 10.5% of the 715 pregnant women. Escherichia coli was the most common etiological factor (26.7%), followed by Klebsiella pneumoniae (20%), Streptococcus agalactiae (9.3%), Enterobacter cloacae (5.3%), Enterococcus faecalis (5.3%), Staphylococcus saprophyticus (4%), Acinetobacter baumannii (4%), and others. Out of 76 pregnant women who took fosfomycin-trometamol, two complained of diarrhea that subsided without medication and fever that responded to paracetamol. Neonatal outcomes showed 100% full-term and normal-weight babies. E. coli, including extended-spectrum beta-lactamase- (ESBL-) producing E. coli, was 100% susceptible to fosfomycin. Nitrite/LE test results are often used as evidence for empiric antibiotic administration for treating asymptomatic bacteriuria in pregnancy, but the diagnosis should be confirmed using culture tests. Based on in vitro susceptibility patterns and medication outcomes, fosfomycin-trometamol single dose could be administered to noncompliant UTI patients, including pregnant women.

Update on the Treatment of Bacterial Urinary Tract Infections

1981 ◽  
Vol 15 (10) ◽  
pp. 738-750 ◽  
Author(s):  
Neil Massoud
Keyword(s):  
Biological Activity ◽  
Single Dose ◽  
Urinary Tract ◽  
Patient Compliance ◽  
Urinary Tract Infections ◽  
Antimicrobial Agents ◽  
Complex Problem ◽  
Tract Infections

The treatment of urinary tract infections (UTIs) has become a complex problem for the clinical practitioner. An understanding of the pharmacology, pharmacokinetics, and in vivo biological activity of antimicrobial agents is needed, as is an understanding of the variables that may influence patient compliance with medication regimens. Although UTIs are usually treated for 10 to 14 days, shorter treatment schedules of seven to ten days or even single-dose regimens are possible. Guidelines for the treatment of UTIs are presented along with suggestions for increased patient compliance.

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