Regulation of 3′,5′-cyclic AMP-dependent protein kinase in the plasma membrane of cod (Gadus callarius) and mouse islets

1975 ◽  
Vol 20 (1) ◽  
pp. 301-318 ◽  
Author(s):  
Brian Davis ◽  
Norman R. Lazarus
Keyword(s):  
Plasma Membrane ◽  
Protein Kinase ◽  
Cyclic Amp ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Mouse Islets

scholarly journals Cyclic AMP-dependent protein kinase stimulates the formation of polyphosphoinositides in lymphocyte plasma membrane

FEBS Letters ◽  
1983 ◽  
Vol 152 (2) ◽  
pp. 195-198 ◽  
Author(s):  
B. Sarkadi ◽  
Ágnes Enyedi ◽  
Anna Faragó ◽  
G. Mészáros ◽  
T. Kremmer ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Protein Kinase ◽  
Cyclic Amp ◽  
Dependent Protein Kinase ◽  
Dependent Protein

Stimulation of an individual cell with peptide hormone in a prescribed region of its plasma membrane results in a compartmentalized cyclic AMP-dependent protein kinase response

1991 ◽  
Vol 6 (3) ◽  
pp. 269-279 ◽  
Author(s):  
E. J. Podesta ◽  
A. R. Solano ◽  
J. R. Lemos
Keyword(s):  
Plasma Membrane ◽  
Protein Kinase ◽  
Cyclic Amp ◽  
Hormone Receptors ◽  
Individual Cell ◽  
Peptide Hormone ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
General Response ◽  
Peptide Hormone Receptors

ABSTRACT This work describes the stimulation by a peptide hormone of an individual cell in a prescribed region of its plasma membrane. When Leydig cells were stimulated via a section of membrane tightly sealed to an electrode containing LH, a very localized area exhibited the morphological change known as 'rounding up', which is a cyclic AMP-dependent protein kinase-mediated response. This localized stimulation did not produce a wider response through intracellular, intermembranous or extra-cellular signals. Each individual cell responded to peptide stimulation gradually, with an increase over time and with dose. In contrast, when the stimulation was accomplished using a non-hydrolysable cyclic AMP analogue in the patch electrode, a general response throughout an individual cell was produced. Locally stimulated peptide hormone receptors, adenylate cyclases and cyclic AMP-dependent protein kinases appear to be closely associated so that second messenger production and the effects it mediates are compartmentalized.

scholarly journals A cytosolic cyclic AMP-dependent protein kinase in Dictyostelium discoideum. I. Properties.

1984 ◽  
Vol 259 (1) ◽  
pp. 654-661 ◽  
Author(s):  
I H Majerfeld ◽  
B H Leichtling ◽  
J A Meligeni ◽  
E Spitz ◽  
H V Rickenberg
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Dictyostelium Discoideum ◽  
Dependent Protein Kinase ◽  
Dependent Protein
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