Permeability of lipid bilayer membranes to biogenic amines and cations: Changes induced by ionophores and correlations with biological activities

1974 ◽  
Vol 18 (1) ◽  
pp. 277-294 ◽  
Author(s):  
M. Schadt ◽  
G. Haeusler
Keyword(s):  
Biogenic Amines ◽  
Lipid Bilayer ◽  
Biological Activities ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes

A model for lasalocid-mediated electrical transport of biogenic amines through lipid bilayer membranes

1982 ◽  
Vol 12 (2-3) ◽  
pp. 97-106 ◽  
Author(s):  
Jaae F. Kinsel ◽  
Eugene I. Melnik ◽  
Siegfried Lindenbaum ◽  
Larry A. Sternson ◽  
Yu.A. Ovchinnikov
Keyword(s):  
Biogenic Amines ◽  
Lipid Bilayer ◽  
Electrical Transport ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes

scholarly journals Molecular Dynamics Study of Surfactin Interaction with Lipid Bilayer Membranes

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Asadollah Asadi ◽  
Arash Abdolmaleki ◽  
Sara Azizi-Shalbaf ◽  
Krishnamoorthy Gurushankar
Keyword(s):  
Lipid Bilayer ◽  
Hydroxy Fatty Acid ◽  
Biological Activities ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes ◽  
Surface And Interface ◽  
Fatty Acid Chain ◽  
Potential Efficacy ◽  
Cyclic Heptapeptide ◽  
Membrane Models

Background: Surfactin is a cyclic heptapeptide that is closed by a β-hydroxy fatty acid chain. This potent biosurfactant is produced by different Bacillus subtilis strains. This lipopeptide has numerous attractive biological activities, including antibacterial, antiviral, antimycoplasma, hemolytic, and other different and powerful surface and interface activities. Methods: Understanding how surfactin binds to different membranes and its mechanism of action can help us modify and optimize its structure to improve the potential efficacy of this lipopeptide in the future. For this purpose, we studied the interaction of this lipopeptide with two types of lipid bilayer models, including palmitoyl-oleoyl-glycero- phosphocholine (POPC) and palmitoyl-oleoyl-phosphtidylglycerol (POPG) as the prokaryotic and eukaryotic membrane models, respectively. Results: The obtained data have shown that the tendency of surfactin for these membranes is different. According to the analysis, this molecule binds to both membranes peripherally, and its interaction with the negative membrane is also more potent compared to the zwitterionic membrane. Moreover, we found that surfactin destabilized POPG more than POPC. This suggests that surfactin may act by modifying the membrane’s bulk physical properties. Conclusions: As a final point, this study has shown that surfactin has different behaviors in the eukaryotic and prokaryotic cell membranes and can modify and amplify its action in order to use it for antibacterial drugs.

Formation of asymmetrical planar lipid bilayer membranes from characterized monolayers

1983 ◽  
Vol 7 (4) ◽  
pp. 299-310 ◽  
Author(s):  
Pierre Tancrède ◽  
Paul Paquin ◽  
André Houle ◽  
Roger M. Leblanc
Keyword(s):  
Lipid Bilayer ◽  
Planar Lipid Bilayer ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes

Calcium-induced reversible assembly of phosphorylated amphiphile within lipid bilayer membranes

2021 ◽  
Author(s):  
Yusuke Shimizu ◽  
Kohei Sato ◽  
Kazushi Kinbara
Keyword(s):  
Membrane Proteins ◽  
Lipid Bilayer ◽  
Phenylene Ethynylene ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes

Inspired by calcium-induced reversible assembly and disassembly of membrane proteins found in nature, here we developed a phosphorylated amphiphile (PA) that contains an oligo(phenylene-ethynylene) unit as a hydrophobic unit and...

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