Cyclic AMP-dependent stimulation of Na,K-ATPase in shark rectal gland

1986 ◽  
Vol 94 (3) ◽  
pp. 205-215 ◽  
Author(s):  
D. Marver ◽  
S. Lear ◽  
L. T. Marver ◽  
P. Silva ◽  
F. H. Epstein
Keyword(s):  
Cyclic Amp ◽  
Rectal Gland ◽  
Shark Rectal Gland ◽  
Stimulation Of

Cyclic AMP stimulates ouabain-insensitive ion movement in shark rectal gland

1984 ◽  
Vol 154 (2) ◽  
pp. 139-144 ◽  
Author(s):  
Patricio Silva ◽  
Kate Spokes ◽  
Jonathan A. Epstein ◽  
Arthur Stevens ◽  
Franklin H. Epstein
Keyword(s):  
Cyclic Amp ◽  
Rectal Gland ◽  
Ion Movement ◽  
Shark Rectal Gland

Mode of activation of salt secretion by C-type natriuretic peptide in the shark rectal gland

1999 ◽  
Vol 277 (6) ◽  
pp. R1725-R1732 ◽  
Author(s):  
Patricio Silva ◽  
Richard J. Solomon ◽  
Franklin H. Epstein
Keyword(s):  
Short Circuit ◽  
Short Circuit Current ◽  
Chloride Secretion ◽  
Squalus Acanthias ◽  
Rectal Gland ◽  
Stimulatory Action ◽  
Kinase C ◽  
Shark Rectal Gland ◽  
Pkc Activation ◽  
Stimulation Of

We studied the modes of activation of the salt-secreting rectal gland of the spiny dogfish, Squalus acanthias, by the native cardiac peptide CNP. The stimulatory action of CNP in isolated perfused glands is inhibited by 10 mM procaine, presumably by blocking release of vasoactive intestinal peptide (VIP) from nerves. Procaine reduces the slope of the dose-response curve of human CNP and that of shark CNP (each P < 0.0001). CNP increases short-circuit current in cultured rectal gland cells from 4.8 ± 1.6 to 27.0 ± 7.8 μA/cm2. It also stimulates the secretion of chloride in isolated perfused glands in the presence of 10 mM procaine from 72 ± 31 to 652 ± 173 μeq ⋅ h−1 ⋅ g−1. These results suggest that CNP has a direct cellular action not mediated by the neural release of VIP. The residual stimulation of perfused glands in the presence of procaine was almost completely inhibited by staurosporine [10 nM; an inhibitor of protein kinase C (PKC)] from 652 ± 173 to 237 ± 61 μeq ⋅ h−1 ⋅ g−1. Although CNP stimulates guanylyl cyclase in shark rectal gland, chloride secretion of perfused glands was not elicited by 8-bromoadenosine-cGMP (8-BrcGMP) alone nor by the activator of PKC phorbol ester. The combination of PKC activation and 8-BrcGMP infusion, however, stimulated chloride secretion in perfused glands from 94 ± 30 to 506 ± 61 μeq ⋅ h−1 ⋅ g−1, a level comparable to that observed in glands blocked with procaine. Several parallel pathways appear to be synergistic in activating chloride secretion stimulated by CNP in the rectal gland.

The mechanism of cyclic AMP stimulation of secretion in the dogfish rectal gland

1980 ◽  
Vol 140 (3) ◽  
pp. 209-216 ◽  
Author(s):  
T. J. Shuttleworth ◽  
J. L. Thompson
Keyword(s):  
Cyclic Amp ◽  
Rectal Gland ◽  
Stimulation Of

Stimulation of cyclic AMP formation and nerve electrical activity by octopamine in the terminal abdominal ganglion of the female gypsy moth Lymantria dispar

2006 ◽  
Vol 1071 (1) ◽  
pp. 63-74 ◽  
Author(s):  
Maria C. Olianas ◽  
Paolo Solari ◽  
Luciana Garau ◽  
Anna Liscia ◽  
Roberto Crnjar ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Electrical Activity ◽  
Gypsy Moth ◽  
Lymantria Dispar ◽  
Abdominal Ganglion ◽  
Stimulation Of
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