Influence of bile acids and free fatty acids on physicochemical properties of LP-X

1978 ◽  
Vol 172 (3) ◽  
pp. 211-221 ◽  
Author(s):  
G. Baggio ◽  
P. Müller ◽  
H. Wieland ◽  
P. D. Niedmann ◽  
D. Seidel
Keyword(s):  
Fatty Acids ◽  
Physicochemical Properties ◽  
Free Fatty Acids ◽  
Bile Acids

scholarly journals Phospholipids are A Potentially Important Source of Tissue Biomarkers for Hepatocellular Carcinoma: Results of a Pilot Study Involving Targeted Metabolomics

Diagnostics ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 167
Author(s):  
Erin B. Evangelista ◽  
Sandi A. Kwee ◽  
Miles M. Sato ◽  
Lu Wang ◽  
Christoph Rettenmeier ◽  
...  
Keyword(s):  
Machine Learning ◽  
Hepatocellular Carcinoma ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Small Molecules ◽  
Bile Acids ◽  
Random Forests ◽  
Liver Tissue ◽  
Classification Performance ◽  
Tissue Biomarkers

Background: Hepatocellular carcinoma (HCC) pathogenesis involves the alteration of multiple liver-specific metabolic pathways. We systematically profiled cancer- and liver-related classes of metabolites in HCC and adjacent liver tissues and applied supervised machine learning to compare their potential yield for HCC biomarkers. Methods: Tumor and corresponding liver tissue samples were profiled as follows: Bile acids by ultra-performance liquid chromatography (LC) coupled to tandem mass spectrometry (MS), phospholipids by LC-MS/MS, and other small molecules including free fatty acids by gas chromatography—time of flight MS. The overall classification performance of metabolomic signatures derived by support vector machine (SVM) and random forests machine learning algorithms was then compared across classes of metabolite. Results: For each metabolite class, there was a plateau in classification performance with signatures of 10 metabolites. Phospholipid signatures consistently showed the highest discrimination for HCC followed by signatures derived from small molecules, free fatty acids, and bile acids with area under the receiver operating characteristic curve (AUC) values of 0.963, 0.934, 0.895, 0.695, respectively, for SVM-generated signatures comprised of 10 metabolites. Similar classification performance patterns were observed with signatures derived by random forests. Conclusion: Membrane phospholipids are a promising source of tissue biomarkers for discriminating between HCC tumor and liver tissue.

scholarly journals COMPARATIVE STUDIES ON EFFECTS OF FREEZING ON PHYSICOCHEMICAL PROPERTIES OF FILLETS TWO FISH SPECIES IN IRAN

2018 ◽  
Vol 12 (1) ◽  
Author(s):  
Ali Aberoumand ◽  
Saeed Ziaei nejad ◽  
Frideh Baesi ◽  
Zahrah Kolyaee
Keyword(s):  
Fatty Acids ◽  
Physicochemical Properties ◽  
Free Fatty Acids ◽  
Fish Species ◽  
Peroxide Value ◽  
Thiobarbituric Acid ◽  
Fish Muscle ◽  
Fish Fillet ◽  
Pampus Argenteus ◽  
Sparidentex Hasta

Because of fishes Sparidentex hasta and Pampus argenteus in the southern of Iran are consumed abundant in a particular season and it should be frozen for consumption throughout the year. Therefore, this research was carried out to investigate the effects of freezing on some of the physicochemical properties of fillets the fishes. Factors such as fat with chloroform-methanol method, amount of TBA (Thiobarbituric acid) in fish muscle accordance method of Pearson, pH using a pH meter, FFA (Free fatty acids) with titration in the presence of phenolphthalein was determined based on the percentage of oleic acid, peroxide value according to AOAC (Association of Official Analytical Chemists), in fresh samples at time zero and after different periods of freezing were tested respectively. Result showd that TBA (Thiobarbituric acid) content in fish fillet, found Pampus argenteus and Sparidentex hasta 0.65 and 0.53 respectively. The results showed that the highest percentage of fat found for Pampus argenteus at 95 days 24.2(%2) and for Sparidentex hasta at 35 days (25.19%), free fatty acids contents found highest (0.9%) and (0.97%) for Sparidentex hasta and Pampus argenteus after 95 days. It can conclude that the TBA (Thiobarbituric acid), FFA (Free fatty acids)  contents and pH of both fish species during storage in freezer were increased. Peroxide value in fish Pampus argenteus was reduced but, in Sparidentex hasta showed no significant differently.  The best time of storage of fishes Pampus argenteus and Sparidentex hasta at -18 °C was 35 days freezing, but nutritional value of fillets and fatty acids greatly reduced

scholarly journals The effect of testosterone on the bile acid and bile lipid composition in rats

2021 ◽  
Author(s):  
I. S. Lupaina ◽  
◽  
A. M. Liashevych ◽  
Y. M. Reshetnik ◽  
S. P. Veselsky ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Bile Acids ◽  
Lipid Composition ◽  
Taurocholic Acid ◽  
The Body ◽  
Female Rats ◽  
Glycocholic Acid ◽  
Physiological Processes ◽  
Free Bile Acids

The study of sexual differences in the regulation of exocrine liver function is one of the topical areas in hepatology. After all, the liver serves as a mediator in a number of systemic effects of sex hormones on the body and is a key organ of their metabolism. In particular, the correlation between the concentration of steroid hormones can determine the direction of physiological processes and their possible distortions. Methods: physiological, biochemical, methods of mathematical statistics. Cholesecretion increased in female rats under the influence of testosterone. Testosterone raised the concentration of taurocholic acid and at the end of the acute experiment the level of taurohenodeoxycholic and taurodeoxycholic acids significantly increased. By comparison, the content of glycocholates decreased significantly immediately after the administration of the hormone but at the end of the experiment, the content of glycocholic acid increased significantly. The level of free bile acids increased under the testosterone. Testosterone affected the bile lipid composition, in particular, it raised the concentrations of phospholipids, cholesterol and its ethers, while the content of free fatty acids decreased under the studied hormone. Testosterone when administered intraperitoneally to female rats significantly affects the concentration of conjugated and free cholate, which may indicate its involvement in metabolic transformations and transport of bile acids to the primary bile ducts. The studied hormone raised the concentration of phospholipids, cholesterol and its ethers, but reduced the content of free fatty acids in the liver secretion of the studied animals.

Sign in / Sign up

Export Citation Format

Share Document