Age-dependent increase in arterial smooth muscle calcium in spontaneously hypertensive rats

1988 ◽  
Vol 188 (6) ◽  
pp. 397-403 ◽  
Author(s):  
C. Spieker ◽  
W. Zidek ◽  
D. B. von Bassewitz ◽  
D. Heck
Keyword(s):  
Smooth Muscle ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Arterial Smooth Muscle ◽  
Spontaneously Hypertensive ◽  
Age Dependent ◽  
Muscle Calcium

Arterial Smooth Muscle Responses in Adult and Moderately Aged Spontaneously Hypertensive Rats

1994 ◽  
Vol 74 (3) ◽  
pp. 167-173 ◽  
Author(s):  
Heikki Wuorela ◽  
Pertti Arvola ◽  
Mika Kähönen ◽  
Heikki Vapaatalo ◽  
Ilkka Pörsti
Keyword(s):  
Smooth Muscle ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Arterial Smooth Muscle ◽  
Spontaneously Hypertensive ◽  
Muscle Responses

scholarly journals Quinapril treatment and arterial smooth muscle responses in spontaneously hypertensive rats

1993 ◽  
Vol 108 (4) ◽  
pp. 980-990 ◽  
Author(s):  
Pertti Arvola ◽  
Heikki Ruskoaho ◽  
Heikki Wuorela ◽  
Anu Pekki ◽  
Heikki Vapaatalo ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Arterial Smooth Muscle ◽  
Spontaneously Hypertensive ◽  
Muscle Responses

Studies of arterial smooth muscle relaxation in younger (16–18 week) and older (28–31 week) spontaneously hypertensive rats

1988 ◽  
Vol 66 (12) ◽  
pp. 1513-1517
Author(s):  
C. S. Packer ◽  
M. L. Kagan ◽  
R. A. Meiss ◽  
N. L. Stephens
Keyword(s):  
Smooth Muscle ◽  
Relaxation Rate ◽  
Spontaneously Hypertensive Rats ◽  
Smooth Muscle Relaxation ◽  
Relaxation Rates ◽  
Hypertensive Rats ◽  
Arterial Smooth Muscle ◽  
Spontaneously Hypertensive ◽  
Isotonic Contractions ◽  
Arterial Muscle

Both isometric and isotonic relaxation rates have previously been reported to be decreased in caudal arterial and mesenteric resistance arterial smooth muscle from 16- to 21-week-old spontaneously hypertensive rats (SHR) compared with muscle from age-matched normotensive Wistar–Kyoto rats (WKY). An increased maximum velocity of shortening (Vmax) and an increased shortening ability (ΔLmax) have also been reported for arterial smooth muscle from 16- to 21-week-old SHR. It has been suggested that both increased narrowing and prolonged narrowing of arteries contribute to the development of hypertension. However, SHR Vmax is not different from WKY Vmax when studying arterial muscle from older (28- to 31-week-old) rats. Thus increased arterial narrowing ability cannot be a contributing factor to the maintenance of hypertension. In this study the role of relaxation rate in the maintenance of hypertension was examined by comparing the relaxation rates of isometric and isotonic contractions of caudal arterial strips from 16- to 21-week-old SHR (n = 9) and WKY (n = 8) and from 28- to 31-week-old SHR (n = 7) and WKY (n = 5). While relaxation rates were lower for 16- to 21-week-old SHR compared with age-matched WKY preparations for both isometric and isotonic contractions, only isometric relaxation rates were found to be different in 28- to 31-week-old SHR compared with 28- to 31-week-old caudal arterial muscle (p < 0.05). Vmax tended to normalize from a once-elevated velocity, while isometric relaxation rate remained decreased in SHR with ageing and (or) with progression of the hypertensive condition. Therefore, slower relaxation, but not increased shortening ability, may contribute to the maintenance of high blood pressure in this genetic model of essential hypertension. A decreased Ca2+ resequestering rate or slower Ca2+ extrusion from the cell or decreased phosphatase activity are some of the possible candidates for the slow relaxation reported for the hypertensive arterial smooth muscle.

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