Comparison of changes in cerebral blood flow and cerebral oxygen saturation measured by near infrared spectroscopy (NIRS) after acetazolamide

1997 ◽  
Vol 139 (1) ◽  
pp. 58-62 ◽  
Author(s):  
M. Holzschuh ◽  
C. Woertgen ◽  
C. Metz ◽  
A. Brawanski
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Infrared Spectroscopy ◽  
Oxygen Saturation ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Cerebral Oxygen Saturation ◽  
Cerebral Oxygen

scholarly journals Changes in cerebral oxygen saturation and cerebral blood flow velocity under mild +Gz hypergravity

2019 ◽  
Vol 127 (1) ◽  
pp. 190-197 ◽  
Author(s):  
Toru Konishi ◽  
Takuya Kurazumi ◽  
Tomokazu Kato ◽  
Chiharu Takko ◽  
Yojiro Ogawa ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Infrared Spectroscopy ◽  
Oxygen Saturation ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Cerebral Oxygenation ◽  
Cerebral Oxygen Saturation ◽  
Cerebral Oxygen ◽  
Regional Cerebral Oxygen Saturation

We previously reported that cerebral blood flow (CBF) was reduced by even mild +Gz hypergravity. Regional cerebral oxygen saturation as measured by near-infrared spectroscopy (C-rSO2) has been widely used to detect cerebral ischemia in clinical practice. For example, decreases in C-rSO2reflect reduced CBF or arterial oxygen saturation. Thus it was hypothesized that C-rSO2would decrease in association with reduced CBF during mild hypergravity. To test this hypothesis, we measured CBF velocity by transcranial Doppler ultrasonography and C-rSO2during mild +Gz hypergravity while participants were in a sitting position. Among 17 male participants, 15 completed 21 min of exposure to +1.5 Gz generated by short-arm centrifuge. C-rSO2and mean CBF velocity in the middle cerebral artery (MCBFVMCA) during centrifugation were averaged every 5 min and compared with pre-hypergravity (+1.0 Gz). C-rSO2did not change significantly throughout centrifugation, although MCBFVMCAgradually decreased from the beginning (−1.2% at 0–5 min), and significantly decreased at 5–10 min (−4.8%), 10–15 min (−6.7%), and 15–20 min (−7.4%). Contrary to our hypothesis, decreases in C-rSO2were not detected, despite reductions in CBF velocity during hypergravity. Since some assumptions, such as unaltered arteriovenous volume ratio, hemoglobin concentration, extracranial blood flow, and brain activity, need to be satisfied to monitor cerebral ischemia by C-rSO2, the present results suggest that these necessary assumptions for near-infrared spectroscopy are not always applicable, and that cerebral oxygenation may not precisely reflect decreases in CBF under mild +Gz hypergravity.NEW & NOTEWORTHY To our knowledge, this is the first study to evaluate simultaneously cerebral oxygenation monitored by near-infrared spectroscopy and cerebral blood flow (CBF) monitored by transcranial Doppler under +1.5 Gz hypergravity. Contrary to our hypothesis, there was no significant correlation between CBF velocity and regional cerebral oxygen saturation (C-rSO2). However, an incomplete case nearly involving syncope suggests the possibility that C-rSO2can detect a remarkable decrease in CBF with development of presyncope during +Gz hypergravity.

scholarly journals Brain oxygen saturation assessment in neonates using T2-prepared blood imaging of oxygen saturation and near-infrared spectroscopy

2016 ◽  
Vol 37 (3) ◽  
pp. 902-913 ◽  
Author(s):  
Thomas Alderliesten ◽  
Jill B De Vis ◽  
Petra MA Lemmers ◽  
Jeroen Hendrikse ◽  
Floris Groenendaal ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Infrared Spectroscopy ◽  
Magnetic Resonance ◽  
Oxygen Saturation ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Sagittal Sinus ◽  
Venous Oxygen Saturation ◽  
Blood Imaging

Although near-infrared spectroscopy is increasingly being used to monitor cerebral oxygenation in neonates, it has a limited penetration depth. The T2-prepared Blood Imaging of Oxygen Saturation (T2-BIOS) magnetic resonance sequence provides an oxygen saturation estimate on a voxel-by-voxel basis, without needing a respiratory calibration experiment. In 15 neonates, oxygen saturation measured by T2-prepared blood imaging of oxygen saturation and near-infrared spectroscopy were compared. In addition, these measures were compared to cerebral blood flow and venous oxygen saturation in the sagittal sinus. A strong linear relation was found between the oxygen saturation measured by magnetic resonance imaging and the oxygen saturation measured by near-infrared spectroscopy ( R2 = 0.64, p < 0.001). Strong linear correlations were found between near-infrared spectroscopy oxygen saturation, and magnetic resonance imaging measures of frontal cerebral blood flow, whole brain cerebral blood flow and venous oxygen saturation in the sagittal sinus ( R2 = 0.71, 0.50, 0.65; p < 0.01). The oxygen saturation obtained by T2-prepared blood imaging of oxygen saturation correlated with venous oxygen saturation in the sagittal sinus ( R2 = 0.49, p = 0.023), but no significant correlations could be demonstrated with frontal and whole brain cerebral blood flow. These results suggest that measuring oxygen saturation by T2-prepared blood imaging of oxygen saturation is feasible, even in neonates. Strong correlations between the various methods work as a cross validation for near-infrared spectroscopy and T2-prepared blood imaging of oxygen saturation, confirming the validity of using of these techniques for determining cerebral oxygenation.

VALIDATION OF PHASE-MODULATED NEAR INFRARED SPECTROSCOPY WITH CEREBRAL OXYGEN SATURATION MEASUREMENTS IN CHILDREN

1998 ◽  
Vol 89 (Supplement) ◽  
pp. 458A
Author(s):  
H Marc Watzman ◽  
C Dean Kurth ◽  
Jonathan Rome ◽  
Susan C Nicolson ◽  
James M Steven ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Oxygen Saturation ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Cerebral Oxygen Saturation ◽  
Cerebral Oxygen
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