The diagnosis and biochemical investigation of a patient with a short chain fatty acid oxidation defect

1985 ◽  
Vol 8 (S2) ◽  
pp. 135-136 ◽  
Author(s):  
M. J. Bennett ◽  
R. G. F. Gray ◽  
D. M. Isherwood ◽  
N. Murphy ◽  
R. J. Pollitt
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Short Chain Fatty Acid ◽  
Chain Fatty Acid ◽  
Short Chain ◽  
Acid Oxidation ◽  
Fatty Acid Oxidation Defect ◽  
Biochemical Investigation

scholarly journals Mitochondrial Preference for Short Chain Fatty Acid Oxidation During Coronary Artery Constriction

Circulation ◽  
2002 ◽  
Vol 105 (3) ◽  
pp. 367-372 ◽  
Author(s):  
E. Douglas Lewandowski ◽  
Raymond K. Kudej ◽  
Lawrence T. White ◽  
J. Michael O’Donnell ◽  
Stephen F. Vatner
Keyword(s):  
Fatty Acid ◽  
Coronary Artery ◽  
Fatty Acid Oxidation ◽  
Short Chain Fatty Acid ◽  
Chain Fatty Acid ◽  
Short Chain ◽  
Acid Oxidation

scholarly journals Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation

2021 ◽  
Vol 118 (22) ◽  
pp. e2014681118
Author(s):  
Fengqi Hao ◽  
Miaomiao Tian ◽  
Xinbo Zhang ◽  
Xin Jin ◽  
Ying Jiang ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Short Chain Fatty Acid ◽  
Chain Fatty Acid ◽  
Metabolic Reprogramming ◽  
Short Chain ◽  
Acid Oxidation ◽  
Immune Homeostasis ◽  
Metabolic Intermediate ◽  
Malonyl Coa

Inducible regulatory T (iTreg) cells play a crucial role in immune suppression and are important for the maintenance of immune homeostasis. Mounting evidence has demonstrated connections between iTreg differentiation and metabolic reprogramming, especially rewiring in fatty acid oxidation (FAO). Previous work showed that butyrate, a specific type of short-chain fatty acid (SCFA) readily produced from fiber-rich diets through microbial fermentation, was critical for the maintenance of intestinal homeostasis and capable of promoting iTreg generation by up-regulating histone acetylation for gene expression as an HDAC inhibitor. Here, we revealed that butyrate could also accelerate FAO to facilitate iTreg differentiation. Moreover, butyrate was converted, by acyl-CoA synthetase short-chain family member 2 (ACSS2), into butyryl-CoA (BCoA), which up-regulated CPT1A activity through antagonizing the association of malonyl-CoA (MCoA), the best known metabolic intermediate inhibiting CPT1A, to promote FAO and thereby iTreg differentiation. Mutation of CPT1A at Arg243, a reported amino acid required for MCoA association, impaired both MCoA and BCoA binding, indicating that Arg243 is probably the responsible site for MCoA and BCoA association. Furthermore, blocking BCoA formation by ACSS2 inhibitor compromised butyrate-mediated iTreg generation and mitigation of mouse colitis. Together, we unveil a previously unappreciated role for butyrate in iTreg differentiation and illustrate butyrate–BCoA–CPT1A axis for the regulation of immune homeostasis.

CYTOKINE-INDUCED IMPAIRMENT OF SHORT-CHAIN FATTY ACID OXIDATION AND VIABILITY IN HUMAN COLONIC EPITHELIAL CELLS

Cytokine ◽  
2000 ◽  
Vol 12 (9) ◽  
pp. 1400-1404 ◽  
Author(s):  
G Pedersen ◽  
T Saermark ◽  
T Horn ◽  
B Giese ◽  
K Bendtzen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Epithelial Cells ◽  
Fatty Acid Oxidation ◽  
Short Chain Fatty Acid ◽  
Chain Fatty Acid ◽  
Short Chain ◽  
Acid Oxidation ◽  
Colonic Epithelial Cells
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