Amino acidaemias and brain maturation: Interference with sulphate activation and myelin metabolism

1985 ◽  
Vol 8 (S2) ◽  
pp. 121-122 ◽  
Author(s):  
F. A. Hommes
Keyword(s):  
Brain Maturation ◽  
Myelin Metabolism

Brain Maturation in Children With Cochlear Implants

ASHA Leader ◽  
2009 ◽  
Vol 14 (5) ◽  
pp. 14-17 ◽  
Author(s):  
Anu Sharma ◽  
Amy Nash
Keyword(s):  
Cochlear Implants ◽  
Brain Maturation

Heterogeneity of Microglia Phenotypes: Developmental, Functional and Some Therapeutic Considerations

2019 ◽  
Vol 25 (21) ◽  
pp. 2375-2393 ◽  
Author(s):  
Yun Yuan ◽  
Chunyun Wu ◽  
Eng-Ang Ling
Keyword(s):  
Brain Lesion ◽  
Translocator Protein ◽  
Trophic Factors ◽  
Microglial Cells ◽  
Brain Maturation ◽  
Activated Microglia ◽  
Proinflammatory Mediators ◽  
Pathological Conditions ◽  
Positron Emission ◽  
M2 Microglia

Background: Microglia play a pivotal role in maintaining homeostasis in complex brain environment. They first exist as amoeboid microglial cells (AMCs) in the developing brain, but with brain maturation, they transform into ramified microglial cells (RMCs). In pathological conditions, microglia are activated and have been classified into M1 and M2 phenotypes. The roles of AMCs, RMCs and M1/M2 microglia phenotypes especially in pathological conditions have been the focus of many recent studies. Methods: Here, we review the early development of the AMCs and RMCs and discuss their specific functions with reference to their anatomic locations, immunochemical coding etc. M1 and M2 microglia phenotypes in different neuropathological conditions are also reviewed. Results: Activated microglia are engaged in phagocytosis, production of proinflammatory mediators, trophic factors and synaptogenesis etc. Prolonged microglia activation, however, can cause damage to neurons and oligodendrocytes. The M1 and M2 phenotypes featured prominently in pathological conditions are discussed in depth. Experimental evidence suggests that microglia phenotype is being modulated by multiple factors including external and internal stimuli, local demands, epigenetic regulation, and herbal compounds. Conclusion: Prevailing views converge that M2 polarization is neuroprotective. Thus, proper therapeutic designs including the use of anti-inflammatory drugs, herbal agents may be beneficial in suppression of microglial activation, especially M1 phenotype, for amelioration of neuroinflammation in different neuropathological conditions. Finally, recent development of radioligands targeting 18 kDa translocator protein (TSPO) in activated microglia may hold great promises clinically for early detection of brain lesion with the positron emission tomography.

Health and Well-Being in Adolescence

2018 ◽  
Author(s):  
Susan M. Sawyer ◽  
George C. Patton
Keyword(s):  
Adolescent Health ◽  
Social Determinants ◽  
Well Being ◽  
Brain Maturation ◽  
Health Determinants ◽  
Physical And Mental Health ◽  
Disability Adjusted Life ◽  
Life Years ◽  
High Benefit ◽  
Health And Well Being

This chapter describes how the profile of physical and mental health and well-being changes across adolescence. The biological context of healthy adolescent growth and development is reviewed, including secular patterns of puberty and brain maturation. The structural and social determinants of adolescent health are then described. Adolescent health outcomes, including patterns of risk behaviors, emerge from the interaction between biological influences and social health determinants. Estimates of mortality and disability-adjusted life years are used to describe three patterns of adolescent health and well-being that vary by age, sex, and national wealth. Globally, the burden of disease increases across adolescence, varying markedly between and within countries. Comprehensive, multisectoral, evidence-informed actions are required that match these conspicuous adolescent health problems, emerging health risks, and major social determinants. Such actions, including quality education and health services, differ greatly from those that benefit younger children yet have similarly high benefit–cost ratios.

scholarly journals Sleep maturation influences cognitive development of preterm toddlers

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Akiko Ando ◽  
Hidenobu Ohta ◽  
Yuko Yoshimura ◽  
Machiko Nakagawa ◽  
Yoko Asaka ◽  
...  
Keyword(s):  
Cognitive Development ◽  
Sleep Duration ◽  
Sleep Time ◽  
Brain Maturation ◽  
Sleep Diary ◽  
Sleep Regulation ◽  
Wake Time ◽  
Daytime Nap ◽  
Nighttime Sleep ◽  
The Relationship

AbstractOur recent study on full-term toddlers demonstrated that daytime nap properties affect the distribution ratio between nap and nighttime sleep duration in total sleep time but does not affect the overall total amount of daily sleep time. However, there is still no clear scientific consensus as to whether the ratio between naps and nighttime sleep or just daily total sleep duration itself is more important for healthy child development. In the current study, to gain an answer to this question, we examined the relationship between the sleep properties and the cognitive development of toddlers born prematurely using actigraphy and the Kyoto scale of psychological development (KSPD) test. 101 premature toddlers of approximately 1.5 years of age were recruited for the study. Actigraphy units were attached to their waist with an adjustable elastic belt for 7 consecutive days and a child sleep diary was completed by their parents. In the study, we found no significant correlation between either nap or nighttime sleep duration and cognitive development of the preterm toddlers. In contrast, we found that stable daily wake time was significantly associated with better cognitive development, suggesting that sleep regulation may contribute to the brain maturation of preterm toddlers.

scholarly journals Neural correlates of memory recovery: Preliminary findings in children and adolescents with acquired brain injury

2021 ◽  
Vol 39 (1) ◽  
pp. 61-71
Author(s):  
Anne-Laure Mouthon ◽  
Andreas Meyer-Heim ◽  
Reto Huber ◽  
Hubertus J.A. Van Hedel
Keyword(s):  
Brain Injury ◽  
Spectral Power ◽  
Recovery Of Function ◽  
Acquired Brain Injury ◽  
Neural Correlates ◽  
Sleep Eeg ◽  
Brain Maturation ◽  
Brain Areas ◽  
Memory Recovery ◽  
Posterior Parietal

Background: After acquired brain injury (ABI), patients show various neurological impairments and outcome is difficult to predict. Identifying biomarkers of recovery could provide prognostic information about a patient’s neural potential for recovery and improve our understanding of neural reorganization. In healthy subjects, sleep slow wave activity (SWA, EEG spectral power 1–4.5 Hz) has been linked to neuroplastic processes such as learning and brain maturation. Therefore, we suggest that SWA might be a suitable measure to investigate neural reorganization underlying memory recovery. Objectives: In the present study, we used SWA to investigate neural correlates of recovery of function in ten paediatric patients with ABI (age range 7–15 years). Methods: We recorded high-density EEG (128 electrodes) during sleep at the beginning and end of rehabilitation. We used sleep EEG data of 52 typically developing children to calculate age-normalized values for individual patients. In patients, we also assessed every-day life memory impairment at the beginning and end of rehabilitation. Results: In the course of rehabilitation, memory recovery was paralleled by longitudinal changes in SWA over posterior parietal brain areas. SWA over left prefrontal and occipital brain areas at the beginning of rehabilitation predicted memory recovery. Conclusions: We show that longitudinal sleep-EEG measurements are feasible in the clinical setting. While posterior parietal and prefrontal brain areas are known to belong to the memory “core network”, occipital brain areas have never been related to memory. While we have to remain cautious in interpreting preliminary findings, we suggest that SWA is a promising measure to investigate neural reorganization.

scholarly journals Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis

2021 ◽  
Author(s):  
Nora Penzel ◽  
◽  
Linda A. Antonucci ◽  
Linda T. Betz ◽  
Rachele Sanfelici ◽  
...  
Keyword(s):  
Gray Matter ◽  
Inferior Frontal Gyrus ◽  
Brain Networks ◽  
Developmental Trajectory ◽  
Cannabis Use ◽  
Brain Maturation ◽  
Confounding Factors ◽  
Recent Onset ◽  
Increased Risk ◽  
Structural Brain

AbstractCannabis use during adolescence is associated with an increased risk of developing psychosis. According to a current hypothesis, this results from detrimental effects of early cannabis use on brain maturation during this vulnerable period. However, studies investigating the interaction between early cannabis use and brain structural alterations hitherto reported inconclusive findings. We investigated effects of age of cannabis initiation on psychosis using data from the multicentric Personalized Prognostic Tools for Early Psychosis Management (PRONIA) and the Cannabis Induced Psychosis (CIP) studies, yielding a total sample of 102 clinically-relevant cannabis users with recent onset psychosis. GM covariance underlies shared maturational processes. Therefore, we performed source-based morphometry analysis with spatial constraints on structural brain networks showing significant alterations in schizophrenia in a previous multisite study, thus testing associations of these networks with the age of cannabis initiation and with confounding factors. Earlier cannabis initiation was associated with more severe positive symptoms in our cohort. Greater gray matter volume (GMV) in the previously identified cerebellar schizophrenia-related network had a significant association with early cannabis use, independent of several possibly confounding factors. Moreover, GMV in the cerebellar network was associated with lower volume in another network previously associated with schizophrenia, comprising the insula, superior temporal, and inferior frontal gyrus. These findings are in line with previous investigations in healthy cannabis users, and suggest that early initiation of cannabis perturbs the developmental trajectory of certain structural brain networks in a manner imparting risk for psychosis later in life.

scholarly journals Nutritional Support of Neurodevelopment and Cognitive Function in Infants and Young Children—An Update and Novel Insights

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 199
Author(s):  
Kathrin Cohen Kadosh ◽  
Leilani Muhardi ◽  
Panam Parikh ◽  
Melissa Basso ◽  
Hamid Jan Jan Mohamed ◽  
...  
Keyword(s):  
Young Children ◽  
Neural Development ◽  
Therapeutic Potential ◽  
Well Being ◽  
Brain Maturation ◽  
Normal Brain ◽  
Neurocognitive Development ◽  
The Individual ◽  
And Behavior ◽  
Infants And Young Children

Proper nutrition is crucial for normal brain and neurocognitive development. Failure to optimize neurodevelopment early in life can have profound long-term implications for both mental health and quality of life. Although the first 1000 days of life represent the most critical period of neurodevelopment, the central and peripheral nervous systems continue to develop and change throughout life. All this time, development and functioning depend on many factors, including adequate nutrition. In this review, we outline the role of nutrients in cognitive, emotional, and neural development in infants and young children with special attention to the emerging roles of polar lipids and high quality (available) protein. Furthermore, we discuss the dynamic nature of the gut-brain axis and the importance of microbial diversity in relation to a variety of outcomes, including brain maturation/function and behavior are discussed. Finally, the promising therapeutic potential of psychobiotics to modify gut microbial ecology in order to improve mental well-being is presented. Here, we show that the individual contribution of nutrients, their interaction with other micro- and macronutrients and the way in which they are organized in the food matrix are of crucial importance for normal neurocognitive development.

scholarly journals MicroRNA-29 is an essential regulator of brain maturation through regulation of CH methylation

Cell Reports ◽  
2021 ◽  
Vol 35 (1) ◽  
pp. 108946
Author(s):  
Vijay Swahari ◽  
Ayumi Nakamura ◽  
Emilie Hollville ◽  
Hume Stroud ◽  
Jeremy M. Simon ◽  
...  
Keyword(s):  
Brain Maturation

scholarly journals Functional network estimation using multigraph learning with application to brain maturation study

2021 ◽  
Author(s):  
Junqi Wang ◽  
Li Xiao ◽  
Wenxing Hu ◽  
Gang Qu ◽  
Tony W. Wilson ◽  
...  
Keyword(s):  
Functional Network ◽  
Brain Maturation ◽  
Network Estimation
Sign in / Sign up

Export Citation Format

Share Document