Racial and age differences in multiple primary cancers after breast cancer: A population-based analysis

1989 ◽  
Vol 14 (2) ◽  
pp. 245-254 ◽  
Author(s):  
Ann Grossbart Schwartz ◽  
Nawal E. Ragheb ◽  
G. Marie Swanson ◽  
William A. Satariano
Keyword(s):  
Breast Cancer ◽  
Age Differences ◽  
Population Based ◽  
Multiple Primary Cancers ◽  
Multiple Primary

Clinical and genetic characteristics of multiple primary cancers (MPC) in groups of familial and sporadic breast cancer (BC).

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. e11047-e11047
Author(s):  
V. D. Petrova ◽  
E. L. Sekerzhinskaya ◽  
I. A. Selezneva ◽  
T. V. Sinkina ◽  
S. A. Terekhova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sporadic Breast Cancer ◽  
Multiple Primary Cancers ◽  
Genetic Characteristics ◽  
Multiple Primary

Inherited mutations in breast cancer patients with and without multiple primary cancers.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 1503-1503
Author(s):  
Kara Noelle Maxwell ◽  
Joseph Vijai ◽  
Jenna Lilyquist ◽  
Thomas Paul Slavin ◽  
Abha Kulkarni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Multiple Primary Cancers ◽  
Breast Cancer Patients ◽  
Multiple Primary ◽  
Inherited Mutations

Synchronous and Metachronous Diagnosis of Multiple Primary Cancers

1998 ◽  
Vol 84 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Emanuele Crocetti ◽  
Stefania Arniani ◽  
Eva Buiatti
Keyword(s):  
Renal Cell ◽  
Case Series ◽  
Population Based ◽  
Multiple Primary Cancers ◽  
Renal Cell Carcinomas ◽  
Time Period ◽  
Skin Cancers ◽  
Multiple Primary ◽  
Synchronous Cancers ◽  
Slow Growing

Aims In the time period near to the diagnosis of a new cancer, other tumors (synchronous cancers), especially slow-growing tumors, may be detected because several diagnostic examinations are performed. The frequency of synchronous in comparison with metachronous carcinomas has been evaluated in a population-based series of multiple primary cancers. Methods The case series of multiple primary cancers of the Tuscany Tumor Registry, incident during the period 1985-1991 was analyzed. For each site of a second independent tumor, the proportions of synchronous (diagnosed within 2 months of the first primary) and metachronous cancers were compared with the mean distribution (all sites except the specific one). Results During 1985-1991, 1095 patients had two independent tumors diagnosed; 216 were synchronous. The proportion of synchronous compared to metachronous cancers was significantly higher for bladder, prostate and renal cell carcinomas; it was significantly lower for lung cancer. When cancers following skin epitheliomas were evaluated, only the proportion of synchronous skin cancers was significantly increased. Conclusions Silent slow-growing tumors are suspected to be more frequent in patients with prostate, bladder or renal cell carcinomas. In fact, they were most frequently diagnosed during ascertainment for another cancer. When few examinations were performed, as after the diagnosis of a skin epithelioma, no difference between metachronous and synchronous cancers was evident, except for skin.

3535 POSTER Differential Factors Clinical and Genetic of Multiple Primary Cancers in Groups of Familial and Sporadic Breast Cancer

2011 ◽  
Vol 47 ◽  
pp. S257
Author(s):  
V.D. Petrova ◽  
I.A. Selezneva ◽  
S.A. Terekhova ◽  
T.V. Sinkina ◽  
A.F. Lazarev ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sporadic Breast Cancer ◽  
Multiple Primary Cancers ◽  
Multiple Primary

scholarly journals Incidence of multiple primary cancers in a cohort of women diagnosed with breast cancer in southeast England

2001 ◽  
Vol 84 (3) ◽  
pp. 435-440 ◽  
Author(s):  
H S Evans ◽  
C M Lewis ◽  
D Robinson ◽  
C M J Bell ◽  
H Møller ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multiple Primary Cancers ◽  
Multiple Primary

scholarly journals A clinical case of multiple primary cancers in a carrier of rare SDK2 and NOTCH2 gene mutations

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Nataliya N. Timoshkina ◽  
Dmitry Y. Gvaldin ◽  
Ekaterina P. Omelchuk ◽  
Larisa N. Vashhenko ◽  
Tatjana V. Ausheva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Soft Tissues ◽  
Gene Mutations ◽  
Left Breast ◽  
Research Centre ◽  
Multiple Primary Cancers ◽  
Caucasian Woman ◽  
Nucleotide Polymorphisms ◽  
National Medical ◽  
Multiple Primary

Abstract Background Genetic predisposition is one of the risk factors for the development of multiple primary cancers (MPCs), the frequency of which increases and ranges from 2 to 17%. This study describes a combination of rare mutations, rs746551843 in the NOTCH2 gene and rs144933006 in the SDK2 gene, in a woman with breast cancer and leiomyosarcoma without a clearly burdened family history. Case presentation A 55-year-old Caucasian woman received complex treatment on the basis of the National Medical Research Centre for Oncology for left breast cancer and leiomyosarcoma of soft tissues of the left thigh. The patient was referred for consultation with a geneticist. Among direct relatives, a maternal aunt with a history of kidney cancer was not a carrier of the studied single nucleotide polymorphisms (SNPs). The healthy son of the patient inherited both mutations. Conclusion Thus, perhaps in the described case, there is a synergistic effect of two alleles of moderate and low penetrance, which led to the phenotype of multiple primary cancers.

scholarly journals Clinical Characteristics and Prognosis Associated with Multiple Primary Cancers in Breast Cancer Patients

2018 ◽  
Vol 21 (1) ◽  
pp. 62 ◽  
Author(s):  
Bong Kyun Kim ◽  
Se Jeong Oh ◽  
Jeong-Yoon Song ◽  
Han-Byoel Lee ◽  
Min Ho Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Clinical Characteristics ◽  
Multiple Primary Cancers ◽  
Breast Cancer Patients ◽  
Multiple Primary

scholarly journals Genetic analysis of multiple primary cancers: A case report

2020 ◽  
Vol 73 (5-6) ◽  
pp. 170-174
Author(s):  
Marko Jevric ◽  
Emilija Filipovic ◽  
Ana Krivokuca
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Previous Treatment ◽  
Primary Treatment ◽  
Left Breast ◽  
Multiple Primary Cancers ◽  
Malignant Neoplasms ◽  
Multiple Cancer ◽  
Primary Tumors ◽  
Multiple Primary

Introduction. The occurrence of more than one primary cancer in the same patient is not very common. Multiple cancer prevalence is about 7.9% and the percentage is lower as the number of multiple primary cancers is higher. The incidence of four or more primary cancers in one patient is very rare and its prevalence is around 0.07%. Case Report. We report a rare case of a female with four histopathologically confirmed primary malignant neoplasms. The first tumor was endometrial carcinoma diagnosed at the age of 52. Three additional metachronous tumors were diagnosed as follows: left breast cancer, melanoma, and contralateral breast cancer. Extensive genetic testing was performed and 19 genes were sequenced using the next generation sequencing (BRCA1, BRCA2, ATM, BRIP1, CDH1, CHEK2, MSH2, MLH1, MSH6, PMS2, EPCAM, NBN, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11 and TP53). Even with the existing indicators of genetic etiology, this case showed no pathogenic mutations in any of these genes. This indicates the existence of other underlying mechanisms such as hormonal factors, previous treatment of the primary and subsequent tumors, environmental factors, gene-gene and gene-environment interactions, as well as immunosuppression that could increase the risk for the second and subsequent malignancies. Conclusion. Detailed information on the biology of multiple primary tumors is important for both clinicians and cancer patients during medical management following primary treatment. In addition, genetic information is very important because it has future implications for both patients and their family members.

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