The risk of cancer in relatives of patients with brain neoplasm

1994 ◽  
Vol 131 (3-4) ◽  
pp. 226-228 ◽  
Author(s):  
D. Sakas ◽  
N. Kalfakis ◽  
M. Panas ◽  
D. Vassilopoulos ◽  
P. Carvounis
Keyword(s):  
Brain Neoplasm ◽  
Risk Of Cancer

Colorectal cancer knowledge and screening rates are lower than for breast cancer even in individuals at high risk of cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A741-A741
Author(s):  
P ANG ◽  
D SCHRAG ◽  
K SCHNEIDER ◽  
K SHANNON ◽  
J JOHNSON ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
High Risk ◽  
Cancer Knowledge ◽  
Risk Of Cancer

Study Hikes Risk of Cancer From AKs

2008 ◽  
Vol 39 (7) ◽  
pp. 1-8
Author(s):  
BRUCE JANCIN
Keyword(s):  
Risk Of Cancer

The risk of cancer in chrysotile asbestos miners and millers

2020 ◽  
pp. 647-648
Author(s):  
E. V. Kovalevskiy ◽  
J. . Schuz ◽  
S. V. Kashanskiy
Keyword(s):  
Working Women ◽  
Chrysotile Asbestos ◽  
Vital Status ◽  
Mortality Risks ◽  
Individual Exposure ◽  
Extensive Data ◽  
The World ◽  
Risk Of Cancer

In 2019, with the aim of assessing mortality risks, the formation of the world’s largest cohort of chrysotile asbestos miners and millers was completed at the largest developed chrysotile mine in the world, including a large proportion of working women with extensive data to assess individual exposure and vital status.

Neuroradiology Manifestations of Li-Fraumeni Syndrome: Epidemiology, Genetics, Imaging Findings, and Management

Neurographics ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 228-235
Author(s):  
S. Naganawa ◽  
T. Donohue ◽  
A. Capizzano ◽  
Y. Ota ◽  
J. Kim ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Soft Tissue Sarcomas ◽  
Suppressor Gene ◽  
Imaging Findings ◽  
Li Fraumeni Syndrome ◽  
Increased Risk ◽  
Li Fraumeni ◽  
Risk Of Cancer

Li-Fraumeni syndrome is a familial cancer predisposition syndrome associated with germline mutation of the tumor suppressor gene 53, which encodes the tumor suppressor p53 protein. Affected patients are predisposed to an increased risk of cancer development, including soft-tissue sarcomas, breast cancer, brain tumors, and adrenocortical carcinoma, among other malignancies. The tumor suppressor gene TP53 plays an important, complex role in regulating the cell cycle, collaborating with transcription factors and other proteins. The disruption of appropriate cell cycle regulation by mutated TP53 is considered to be the cause of tumorigenesis in Li-Fraumeni syndrome. Appropriate surveillance, predominantly by using MR imaging, is used for early malignancy screening in an effort to improve the survival rate among individuals who are affected. Patients with Li-Fraumeni syndrome are also at increased risk for neoplasm development after radiation exposure, and, therefore, avoiding unnecessary radiation in both the diagnostic and therapeutic settings is paramount. Here, we review the epidemiology, genetics, imaging findings, and the current standard surveillance protocol for Li-Fraumeni syndrome from the National Comprehensive Cancer Network as well as potential treatment options.Learning Objective: Describe the cause of second primary malignancy among patients with Li-Fraumeni syndrome.

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