Circulating immune complex and NK-cell activity in progressive breast cancer

1984 ◽  
Vol 4 (1) ◽  
pp. 54-55 ◽  
Author(s):  
Raksha Seth ◽  
Seth Pradeep
Keyword(s):  
Breast Cancer ◽  
Immune Complex ◽  
Nk Cell ◽  
Cell Activity ◽  
Nk Cell Activity ◽  
Circulating Immune Complex

Analysis of the Effect of Psychological Nursing Intervention on Perioperative Mood and NK Cell Activity in Breast Cancer Patients

2021 ◽  
Vol 7 (5) ◽  
pp. 3301-3314
Author(s):  
Jihong Yuan ◽  
Linghong Yuan ◽  
Yi Hu ◽  
Jingjing Gong ◽  
Yang Tong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Nk Cell ◽  
Psychological Intervention ◽  
Cell Activity ◽  
Nursing Intervention ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Nk Cell Activity ◽  
Intervention Measures

Breast cancer (Breast Cancer, BC) is one of the most common malignant tumors in women in the world. It is the first malignant tumor that causes the death of women in developing countries. It seriously threatens the lives and health of women and causes damage to the family, economy and society. Through psychological nursing intervention, it has a positive effect on the perioperative mood and NK cell activity of breast cancer patients. The purpose of this article is to explore the effects of psychological intervention on the perioperative mood and NK cell activity of breast cancer patients. This article is based on the concept and theory of psychological nursing intervention for female breast cancer patients, and establishes personalized intervention measures in conjunction with clinical practice to intervene the emotions of breast cancer patients during the perioperative period. This article analyzes the nature, intensity, and causes of negative psychology of the subject through in-depth understanding of the subject’s psychological emotions, coping ability, personality characteristics, past emotional experience, and social support, and discovers the different emotional characteristics of the patient, and formulates the personality psychological intervention measures to stimulate positive and optimistic attitudes and ease the degree of negative psychology. This article analyzes the psychological characteristics of several breast cancer patients. Take corresponding psychological intervention measures. Cope with a series of bad psychology caused by image damage caused by total mastectomy. The results and data in this article show that the incidence of anxiety and depression in the control group is higher than that of the psychological intervention group at 7 days after the operation, with P values of 0.0059 and 0. 0215.Psychological intervention reduces the incidence of negative emotions and reduces the negativeness of patients. The intensity of emotion has played a good clinical effect.

5108 POSTER Association of Decreased NK Cell Activity and IFNgamma Expression With pSTAT Dysregulation in Breast Cancer Patients

2011 ◽  
Vol 47 ◽  
pp. S362 ◽  
Author(s):  
S. Radenkovic ◽  
G. Konjevic ◽  
T. Srdic Rajic ◽  
L. Stamatovic ◽  
M. Milovic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Nk Cell ◽  
Cell Activity ◽  
Breast Cancer Patients ◽  
Nk Cell Activity

Analysis of the Effect of Psychological Nursing Intervention on Perioperative Mood and NK Cell Activity in Breast Cancer Patients

2021 ◽  
Vol 7 (4) ◽  
pp. 443-456
Author(s):  
Jihong Yuan ◽  
Linghong Yuan ◽  
Yi Hu ◽  
Jingjing Gong ◽  
Yang Tong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Nk Cell ◽  
Psychological Intervention ◽  
Cell Activity ◽  
Nursing Intervention ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Nk Cell Activity ◽  
Intervention Measures

Breast cancer (Breast Cancer, BC) is one of the most common malignant tumors in women in the world. It is the first malignant tumor that causes the death of women in developing countries. It seriously threatens the lives and health of women and causes damage to the family, economy and society. Through psychological nursing intervention, it has a positive effect on the perioperative mood and NK cell activity of breast cancer patients. The purpose of this article is to explore the effects of psychological intervention on the perioperative mood and NK cell activity of breast cancer patients. This article is based on the concept and theory of psychological nursing intervention for female breast cancer patients, and establishes personalized intervention measures in conjunction with clinical practice to intervene the emotions of breast cancer patients during the perioperative period. This article analyzes the nature, intensity, and causes of negative psychology of the subject through in - depth understanding of the subject's psychological emotions, coping ability, personality characteristics, past emotional experience, and social support, and discovers the different emotional characteristics of the patient, and formulates the personality psychological intervention measures to stimulate positive and optimistic attitudes and ease the degree of negative psychology. This article analyzes the psychological characteristics of several breast cancer patients. Take corresponding psychological intervention measures. Cope with a series of bad psychology caused by image damage caused by total mastectomy. The results and data in this article show that the incidence of anxiety and depression in the control group is higher than that of the psychological intervention group at 7 days after the operation, with P values of 0.0059 and 0. 0215. Psychological intervention reduces the incidence of negative emotions and reduces the negativeness of patients. The intensity of emotion has played a good clinical effect.

scholarly journals Identification for antitumor effects of tramadol in a xenograft mouse model using orthotopic breast cancer cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Myoung Hwa Kim ◽  
Jeong-Rim Lee ◽  
Ki-Joon Kim ◽  
Ji Hae Jun ◽  
Hye Jeong Hwang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nk Cell ◽  
Cell Activity ◽  
Treated Group ◽  
Control Group ◽  
Nk Cell Activity ◽  
Clinical Dose ◽  
Group 2 ◽  
Mcf 7 ◽  
Group 1

AbstractIn our previous research showed that tramadol having potential anti-tumor effect was associated with enhancement of oncological prognosis in patients with breast cancer surgery. As these effects have not been confirmed by clinical dose-regulated animal or prospective human studies, we investigated the anti-tumor effect of tramadol in vivo. Female nude mice orthotopically inoculated with luciferase-expressing MCF-7 cells, were randomly divided into the control (saline), tramadol group 1 (1.5 mg kg−1 day−1), tramadol group 2 (3 mg kg−1 day−1), and morphine (0.5 mg kg−1 day−1) (n = 5/group). Bioluminescence signals after D-luciferin injection, tumor size, and tumor weight were compared among groups after 4 weeks. Estrogen receptor (ER), progesterone receptor (PR), and transient receptor potential vanilloid (TRPV)-1 expression, natural killer (NK) cell activity, and serum interleukin (IL)-1β, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-6 were then examined. Tumour growth was attenuated in tramadol-treated groups (P < 0.05). NK cell activity was significantly decreased only in the morphine treated group not in sham, control, and tramadol groups. The expression levels of ERα, PRα and β, and TRPV1 were decreased in tramadol group 2 compared with those in the morphine group, but not compared to the control group. Serum levels of IL-6 and TNFα were reduced in both tramadol-treated group 1 and 2 compared to the control group. Overall, clinical dose of tramadol has anti-tumour effects on MCF-7 cell-derived breast cancer in a xenograft mouse model.

A role for peripheral natural killer (NK) cell activity in the response to neoadjuvant chemotherapy in patients with breast cancer.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e12073-e12073
Author(s):  
Ryungsa Kim ◽  
Ami Kawai ◽  
Megumi Wakisaka ◽  
Hitomi Garaku ◽  
Naomi Yasuda ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Natural Killer ◽  
Nk Cell ◽  
Cell Activity ◽  
Nk Cell Activity ◽  
Response To Neoadjuvant Chemotherapy

Immune Responses to Guided Imagery During Breast Cancer Treatment

2008 ◽  
Vol 9 (3) ◽  
pp. 205-214 ◽  
Author(s):  
Cecile A. Lengacher ◽  
Mary P. Bennett ◽  
Lois Gonzalez ◽  
Danielle Gilvary ◽  
Charles E. Cox ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nk Cells ◽  
Guided Imagery ◽  
Nk Cell ◽  
Intervention Group ◽  
Cell Activity ◽  
Control Group ◽  
Cell Cytotoxicity ◽  
Nk Cell Activity ◽  
Nk Cell Cytotoxicity

Background: The use of relaxation and guided imagery to reduce stress and improve immune function has great potential benefits for patients with breast cancer. Methods: This pilot study used a pretest—posttest experimental design with 28 breast cancer patients, aged 25 to 75 years, with the diagnosis of stage 0, 1, or 2 breast cancer. The experimental group received a relaxation and guided imagery intervention and the control group received standard care. The effects of the intervention on immune function were measured by natural killer (NK) cell cytotoxicity and IL-2—activated NK cell activity prior to surgery and 4 weeks postsurgery. NK cell activity was measured using a 15-hr incubation chromium release assay. Cytotoxicity of NK cells was measured against chromium-labeled K-562 target cells. IL-2 was used to enhance reactivity of NK cells against tumor cells. After incubation for 15 hr, cytotoxicity was measured through the release of radioactive chromium. Results: Significant differences between groups were found at 4 weeks postsurgery. T-tests showed increased NK cell cytotoxicity for the intervention group at 100:1, 50:1, and 25:1 effector cell: target cell ratios (E:T) ( p < .01 to p < .05) and increased activation for IL-2 at 100:1, 50:1, 25:1, and 12.5:1 (E:T) ( p < .01 to p < .05) for the intervention group as compared to the control group. Discussion: These findings suggest that a relaxation intervention such as guided imagery could have an effect on NK cell cytotoxicity and NK cell cytotoxicity after activation with IL-2 in patients undergoing surgery for breast cancer.

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