Cyclic nucleotide levels in human breast cancer and in rat mammary tissues during tumor development

1985 ◽  
Vol 6 (3) ◽  
pp. 241-248 ◽  
Author(s):  
Ella Israeli ◽  
Batya Raz ◽  
Hedwiga Kerner ◽  
David Barzilai
Keyword(s):  
Breast Cancer ◽  
Cyclic Nucleotide ◽  
Human Breast Cancer ◽  
Tumor Development ◽  
Human Breast ◽  
Mammary Tissues

High-risk HPVs in human breast cancer and normal mammary tissues

The Breast ◽  
2007 ◽  
Vol 16 (5) ◽  
pp. 445 ◽  
Author(s):  
A. Yasmeen ◽  
R. Ricciardi ◽  
A. Kassab ◽  
T.A. Bismar ◽  
A.-E. Al Moustafa
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Mammary Tissues

scholarly journals Inhibition of miR-660-5p expression suppresses tumor development and metastasis in human breast cancer

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Y. Shen ◽  
Y.F. Ye ◽  
L.W. Ruan ◽  
L. Bao ◽  
M.W. Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Tumor Development ◽  
Human Breast

scholarly journals The role of semaphorin 4D in tumor development and angiogenesis in human breast cancer

2016 ◽  
Vol Volume 9 ◽  
pp. 5737-5750 ◽  
Author(s):  
Hongchao Jiang ◽  
Ceshi Chen ◽  
Qiangming Sun ◽  
Jing Wu ◽  
Lijuan Qiu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Tumor Development ◽  
Human Breast ◽  
Semaphorin 4D

scholarly journals Mice developing mammary tumors evolve T cell sequences shared with human breast cancer patients

2018 ◽  
Author(s):  
Miri Gordin ◽  
Hagit Philip ◽  
Alona Zilberberg ◽  
Moriah Gidoni ◽  
Raanan Margalit ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
T Cell ◽  
Cancer Patients ◽  
Human Breast Cancer ◽  
Tumor Development ◽  
Mammary Tumors ◽  
Cell Receptor ◽  
Breast Cancer Patients ◽  
Human Breast

AbstractCancer immunotherapy by checkpoint blockade proves that an effective immune response to a tumor can be induced clinically. However, little is known about the evolution of tumor-associated T-cell receptor (TCR) repertoires without intervention. Here we studied TCR repertoire evolution in mice spontaneously developing mammary tumors; we sequenced peripheral blood alpha and beta TCRs of CD4+CD62L+CD44− T cells monthly for 8 months in 10 FVB/NJ mice transgenic at the Erbb2 locus, all developing tumors; 5 FVB/NJ mice without the transgene were age-matched controls. Sequences were either private (restricted to one mouse) or public (shared among mice); public sequences were either exclusive to the tumor group or inclusive among different groups. We now report that 1), public AA sequences were each encoded by many different nucleotide sequences (NT) recombinations (convergent recombination; CR); 2) mice developing tumors evolved tumor-exclusive public sequences, derived initially from private or from inclusive public sequences; and 3) tumor-exclusive public sequences in mice were also present among published public TCR sequences from human breast cancer patients. These cross-species tumor-exclusive TCR sequences manifested high CR; but the AA sequences shared by mice and humans did not share NT sequences. Thus, tumor-exclusive TCR AA sequences across species are selected from different NT recombination events. The roles of tumor-exclusive TCR repertoires in advancing or inhibiting tumor development and the effects of tumor immunotherapy on these T cells remain to be seen.

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

Further Ultrastructural Observations on Metastatic Nodules of Human Breast Cancer

1968 ◽  
Vol 26 ◽  
pp. 224-225
Author(s):  
John L. Swedo ◽  
R. W. Talley ◽  
John H. L. Watson
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Estrogen Therapy ◽  
Specimen Preparation ◽  
Human Breast ◽  
Autophagic Vacuoles ◽  
Previous Communication ◽  
Linear Profiles ◽  
Metastatic Nodule

Since the report, which described the ultrastructure of a metastatic nodule of human breast cancer after estrogen therapy, additional ultrastructural observations, including some which are correlative with pertinent findings in the literature concerning mycoplasmas, have been recorded concerning the same subject. Specimen preparation was identical to that in.The mitochondria possessed few cristae, and were deteriorated and vacuolated. They often contained particulates and fibrous structures, sometimes arranged in spindle-shaped bundles, Fig. 1. Another apparent aberration was the occurrence, Fig. 2 (arrows) of linear profiles of what seems to be SER, which lie between layers of RER, and are often recognizably continuous with them.It was noted that the structure of the round bodies, interpreted as within autophagic vacuoles in the previous communication, and of vesicular bodies, described morphologically closely resembled those of some mycoplasmas. Specifically, they simulated or reflected the various stages of replication reported for mycoplasmas grown on solid nutrient. Based on this observation, they are referred to here as “mycoplasma-like” structures, in anticipation of confirmatory evidence from investigations now in progress.

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