Endocrine therapy testing of human breast cancers in the soft agar clonogenic assay

1985 ◽  
Vol 6 (3) ◽  
pp. 229-235 ◽  
Author(s):  
C. Kent Osborne ◽  
Daniel D. Von Hoff ◽  
Kathryn Mullins
Keyword(s):  
Endocrine Therapy ◽  
Clonogenic Assay ◽  
Soft Agar ◽  
Breast Cancers ◽  
Human Breast ◽  
Soft Agar Clonogenic Assay

Immunocytochemical localization of fos protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy

1995 ◽  
Vol 64 (4) ◽  
pp. 269-273 ◽  
Author(s):  
Julia M. W. Gee ◽  
Ian O. Ellis ◽  
John F. R. Robertson ◽  
Peter Willsher ◽  
Richard A. McClelland ◽  
...  
Keyword(s):  
Endocrine Therapy ◽  
Prognostic Markers ◽  
Immunocytochemical Localization ◽  
Breast Cancers ◽  
Human Breast ◽  
Fos Protein

scholarly journals Three New Steroid Biglycosides, Plancisides A, B, and C, from the Starfish Acanthaster planci

2014 ◽  
Vol 9 (9) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Alla A. Kicha ◽  
Thi H. Dinh ◽  
Natalia V. Ivanchina ◽  
Timofey V. Malyarenko ◽  
Anatoly I. Kalinovsky ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
Colony Formation ◽  
Clonogenic Assay ◽  
Ethanolic Extract ◽  
Soft Agar ◽  
Steroid Glycoside ◽  
Acanthaster Planci ◽  
Hct 116 ◽  
Soft Agar Clonogenic Assay

Three new steroid biglycosides, plancisides A-C (1-3), were isolated from the ethanolic extract of the starfish Acanthaster planci. The structures of 1-3 were determined by extensive NMR and ESI-MS techniques, as (24 S)-28- O-[β-D-galactofuranosyl-(1→5)-α-L-arabinofuranosyl]-24-methyl-5α-cholestane-3β,4β,6α,8,15β,16β,28-heptol (1), (24 S)-28- O-[α-L-fucopyranosyl-(1→2)-3- O-methyl-β-D-xylopyranosyl]–24-methyl-5α-cholestane-3β,4β,6α,8,15β,16β,28-heptol (2) and (24 S)-28- O-[2,4-di- O-methyl-β-D-xylopyranosyl-(1→2)-α-L-arabinofuranosyl]-24-methyl-5α-cholestane-3β,4β,6α,8,15β,16β,28-heptol 6- O-sulfate (3), respectively. Compound 2 is the first steroid glycoside containing an α-fucopyranose unit found from starfish. Compound 1 slightly inhibits cell proliferation of HCT-116, T-47D, and RPMI-7951 cancer cell lines, but has no effect on colony formation of these cells in a soft agar clonogenic assay.

scholarly journals The Role of Estrogen in the Development of Breast Cancer

2021 ◽  
Vol 7 (2) ◽  
pp. 231-241
Author(s):  
Nikki Aldi Massardi
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Tumor Growth ◽  
Endocrine Therapy ◽  
Breast Cancers ◽  
Mitogenic Effect ◽  
Human Breast ◽  
Clinically Significant ◽  
Circulating Levels

Breast cancer is a hormone-dependent disease that relies on the mitogenic effect ofestrogen to increase tumorigenesis and tumor growth. Clinically significant levels ofestrogen-α receptor (ERα) expression are seen in 80% of human breast cancers,whereas progesterone receptor is expressed in 55% of human breast cancers. Thesedata are one of the bases for the development of endocrine therapy. Endocrinetherapy is therapy that targets the pathway and synthesis of estrogen, by blocking itvia receptors, reducing circulating levels of estrogen, or suppressing estrogensynthesis in the tissues of women diagnosed with breast cancer.

A simple method of delayed processing of tumor tissue in a soft agar clonogenic assay

1988 ◽  
Vol 114 (2) ◽  
pp. 170-176 ◽  
Author(s):  
Walter Krischke ◽  
Rolf Hartmann ◽  
Martin Schneider ◽  
Helmut Sch�nenberger
Keyword(s):  
Tumor Tissue ◽  
Clonogenic Assay ◽  
Soft Agar ◽  
Simple Method ◽  
Soft Agar Clonogenic Assay

Intersite Variation of Estrogen Receptors in Human Breast Cancers and Response to Endocrine Therapy

Oncology ◽  
1992 ◽  
Vol 49 (2) ◽  
pp. 89-92 ◽  
Author(s):  
Yuichi lino ◽  
Noritaka Sugamata ◽  
Michio Maemura ◽  
Takeshi Takeo ◽  
Susumu Owada ◽  
...  
Keyword(s):  
Estrogen Receptors ◽  
Endocrine Therapy ◽  
Breast Cancers ◽  
Human Breast
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