Prostate specific antigen — a new constituent of breast cyst fluid

1996 ◽  
Vol 38 (3) ◽  
pp. 259-264 ◽  
Author(s):  
Eleftherios P. Diamandis ◽  
He Yu ◽  
Carlos López-Otín
Keyword(s):  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Cyst Fluid ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Antigen A

scholarly journals Immunofluorometric assay of pepsinogen C and preliminary clinical applications

1997 ◽  
Vol 43 (8) ◽  
pp. 1365-1371 ◽  
Author(s):  
Eleftherios P Diamandis ◽  
Sheila Nadkarni ◽  
Banani Bhaumik ◽  
Aly Abdelrahman ◽  
Dimitrios N Melegos ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Amniotic Fluid ◽  
Seminal Plasma ◽  
Specific Antigen ◽  
Diagnostic Value ◽  
Cyst Fluid ◽  
Breast Diseases ◽  
Breast Cyst Fluid ◽  
Pepsinogen C ◽  
Breast Cyst

Abstract We developed mouse monoclonal antibodies (Abs) against pepsinogen C with highly purified antigen isolated from gastric mucosa. The Abs were used to construct a two-site sandwich-type assay for pepsinogen C with time-resolved fluorometry as a detection technique. The assay has a detection limit of 0.1 μg/L and is precise (within-run and day-to-day CVs <11%). We used this assay to measure pepsinogen C in seminal plasma, breast cyst fluid, amniotic fluid, male and female serum, serum from patients with prostate cancer, urine, breast tumor cytosolic extracts, breast milk, and cerebrospinal fluid. Highest pepsinogen C concentrations were in seminal plasma, followed by breast cyst fluid and amniotic fluid. We found no correlation between prostate-specific antigen concentrations and concentrations of pepsinogen C in serum of prostate cancer patients, and concluded that this marker is not useful for either diagnosing or monitoring prostatic carcinoma. The availability of a highly sensitive, reliable, and convenient method for quantifying pepsinogen C will allow investigations into the possible diagnostic value of this analyte in various clinical conditions, including benign breast diseases, breast cancer, fertility, and pregnancy.

Hormonal characterization and classification of breast cyst fluid in gross cystic mastopathy

1994 ◽  
Vol 1 (2) ◽  
pp. 49-55 ◽  
Author(s):  
I Számel ◽  
B Budai ◽  
K Daubner ◽  
J Kralovánszky ◽  
Sz Ottó ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sex Steroids ◽  
Linear Regression Analysis ◽  
Cyst Fluid ◽  
Type I ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Apocrine Metaplasia ◽  
Endocrine Parameters

ABSTRACT Gross cystic disease (GCD) of the breast may be associated with a higher risk for the development of breast cancer. High levels of sex steroids, steroid hormone precursors, prolactin and cations have been found in breast cyst fluid (BCF) by several investigators. Accordingly, endocrine parameters and the cationic composition of BCF may be considered as useful characteristics to follow patients bearing macrocysts. In this study we have investigated the concentrations of estradiol (E2), progesterone, testosterone, dehydroepiandrosterone (DHA) and DHA-3-sulfate (DHA-S), prolactin, potassium (K+) and sodium (Na+) in BCF aspirated from 99 women. The mean age of the patients was 49.8 years (range 32-58). The hormone levels were measured by RIA methods; K+ and Na+ were determined by flame photometry. Estradiol, progesterone, testosterone, DHA, DHA-S, prolactin and K+ showed significant accumulation in the BCF compared with their respective serum values. The K+/Na+ ratio proved to be useful in dividing cysts into type I (≥1), type II (<1 but ≥0.1) and type III (<0.1) subgroups. For type I BCF, higher DHA, DHA-S and prolactin concentrations were detected. Linear regression analysis established a highly significant (P<0.001) correlation between the concentrations of E2 and DHA-S (r=0.686), and also between testosterone and DHA-S (r=0.711). These findings indicate that type I BCF might be a marker for 'active' GCD of the breast, and suggest that it may be associated with an increased breast cancer risk, since this group of patients is supposed to have cysts with apocrine metaplasia. It is suggested therefore that when BCF is aspirated, sex steroids, steroid precursors and cations should be routinely measured, and women with type I cysts should be regularly examined.

Estroe-3-Sulfate in Human Breast Cyst Fluid

1990 ◽  
Vol 595 (1 Steroid Forma) ◽  
pp. 464-466 ◽  
Author(s):  
F. Orlandi ◽  
P. Caraci ◽  
B. Puligheddu ◽  
M. Torta ◽  
L. Dogliotti ◽  
...  
Keyword(s):  
Cyst Fluid ◽  
Human Breast ◽  
Breast Cyst Fluid ◽  
Breast Cyst

Apocrine cells in breast cyst fluid and their relationship to cyst type: A morphometric Study

1988 ◽  
Vol 24 (4) ◽  
pp. 597-602 ◽  
Author(s):  
Donatella Beccati ◽  
Nadia Grilli ◽  
Patrizia Schincaglia ◽  
Carlo Naldoni ◽  
Licia Tavolazzi ◽  
...  
Keyword(s):  
Type A ◽  
Cyst Fluid ◽  
Morphometric Study ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Cyst Type

Quantification of prostate-specific antigen immunoreactivity in human breast cyst fluids

1996 ◽  
Vol 38 (3) ◽  
pp. 247-252 ◽  
Author(s):  
Ferdinando Mannello ◽  
GianDomenico Bocchiotti ◽  
Giuseppe Bianchi ◽  
Francesco Marcheggiani ◽  
Giancarlo Gazzanelli
Keyword(s):  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Human Breast ◽  
Breast Cyst ◽  
Cyst Fluids

Catecholestrogen Content and Ratios in Breast Cyst Fluid

1990 ◽  
Vol 595 (1 Steroid Forma) ◽  
pp. 455-458
Author(s):  
O. M. Granata ◽  
F. Arcuri ◽  
E. Fecarotta ◽  
G. Brignone ◽  
L. Blasi ◽  
...  
Keyword(s):  
Cyst Fluid ◽  
Breast Cyst Fluid ◽  
Breast Cyst

Menstrual cycle-dependent variations of breast cyst fluid proteins and sex steroid receptors in the normal human breast

Cancer ◽  
1983 ◽  
Vol 51 (7) ◽  
pp. 1297-1302 ◽  
Author(s):  
John S. Silva ◽  
Gregory S. Georgiade ◽  
William G. Dilley ◽  
Kenneth S. McCarty ◽  
Samuel A. Wells ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Steroid Receptors ◽  
Cyst Fluid ◽  
Sex Steroid ◽  
Human Breast ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Normal Human Breast ◽  
Normal Human ◽  
Cycle Dependent
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